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Diabetes Insipidus

  • Chapter
The Pituitary Gland

Part of the book series: Clinical Surveys in Endocrinology ((CSED,volume 1))

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Abstract

The diabetes insipidus syndrome is characterized by the inability to concentrate urine or conserve water. The term insipidus reflects the pale, almost colorless waterlike urine excreted by patients in the fully expressed syndrome. Diabetes insipidus results from either impaired synthesis and release of vasopressin (central diabetes insipidus, neurogenic diabetes insipidus, vaso-pressin-sensitive diabetes insipidus) or peripheral resistance to the actions of vasopressin at the level of its target organ, the renal tubules (nephrogenic diabetes insipidus). Regardless of the type, the resulting disturbances in water metabolism are identical, with the continuous production of extremely large volumes of very dilute urine. Diabetes insipidus can be partial or complete, temporary or permanent.

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References

  1. Braverman LE, Mancini JP, McGoldrick DPM: Hereditary idiopathic diabetes insipidus-A case report with autopsy findings. Ann Intern Med 63:504, 1965.

    Google Scholar 

  2. Legros JJ, Crabbe J: Serum neurophysins in familial central diabetes insipidus. J Clin Endocrinol Metab 47:1065, 1978.

    Article  PubMed  CAS  Google Scholar 

  3. Nagai I, Li CH, Hsieh SM, et al: Two cases of hereditary diabetes insipidus, with an autopsy finding in one. Acta Endocrinol (Copenh) 105:318, 1984.

    CAS  Google Scholar 

  4. Laszlo FA, de Wied D: Antidiuretic hormone content of the hypothalamoneurohypophyseal system and urinary excretion of antidiuretic hormone in rats during the development of diabetes insipidus after lesions in the pituitary stalk. J Endocrinol 36:125, 1966.

    Article  PubMed  CAS  Google Scholar 

  5. Kovacs K, Laszlo FA, David MA: The antidiuretic phase of water metabolism in rats after lesions of the pituitary stalk. II. The role of the antidiuretic hormone. J Endocrinol 25:397, 1962.

    Article  PubMed  CAS  Google Scholar 

  6. Petto CK, DeGirolami U, Earle KM: Craniopharyngiomas: A clinical and pathological review. Cancer 37:1944, 1976.

    Article  Google Scholar 

  7. Thomsett MJ, Conte FA, Kaplan SL, et al: Endocrine and neurologic outcome in childhood craniopharyngioma: Review of effect of treatment in 42 patients. J Pediatr 97:728, 1980.

    Article  PubMed  CAS  Google Scholar 

  8. Jennings MT, Gelman R, Hochberg F: Intracranial germ-cell tumors: Natural history and pathogenesis. J Neurosurg 63:155, 1985.

    Article  PubMed  CAS  Google Scholar 

  9. Suprasellar tumors in children: A review of clinical manifestations and managements. Cancer 50:1420, 1982.

    Article  Google Scholar 

  10. Kimmel DW, O’Neill BP: Systemic cancer presenting as diabetes insipidus. Cancer 52:2355, 1983.

    Article  PubMed  CAS  Google Scholar 

  11. Yap HY, Tashima CK, Blumenschein MD, et al: Diabetes insipidus and breast cancer. Arch Intern Med 139:1009, 1979.

    Article  PubMed  CAS  Google Scholar 

  12. Case Records of the Massachusetts General Hospital: Case 33-1983.N Engl J Med 309:418, 1983.

    Article  Google Scholar 

  13. Braunstein GD, Kohler PO: Pituitary function in Hand-Schuller-Christian disease: Evidence for deficient growth-hormone release in patients with short stature. N Engl J Med 286:1225, 1972.

    Article  PubMed  CAS  Google Scholar 

  14. Rowland RS: Christian’s syndrome and lipoid cell hyperplasias of the reticuloendothelial system. Ann Intern Med 2:1277, 1929.

    CAS  Google Scholar 

  15. Avioli LV, Lasersohn JT, Lopresti JM: Histiocytosis X (Schuller-Christian disease): A clinicopathological survey, review of ten patients and the results of prednisone therapy. Medicine (Baltimore) 42:119, 1963.

    Article  CAS  Google Scholar 

  16. Avery ME, McAfee JG, Guild HG: The course and prognosis of reticuloendotheliosis (eosinophilic granuloma, Schuller-Christian disease and Letterer-Siwe disease): A study of forty cases. Am J Med 22:636, 1957.

    Article  PubMed  CAS  Google Scholar 

  17. Pressman BD, Waldron RL, II, Wood EH: Histiocytosis-X of the hypothalamus. Br. J. Radiol 48:176, 1975.

    Article  PubMed  CAS  Google Scholar 

  18. Zinkham WH: Multifocal eosinophilic granuloma-natural history, etiology and management. Am J Med 60:457, 1976.

    Article  PubMed  CAS  Google Scholar 

  19. Rothman JG, Snyder PJ, Utiger RD, et al: Hypothalamic endocrinopathy in Hand-Schuller-Christian disease. Ann Intern Med 88:512, 1978.

    PubMed  CAS  Google Scholar 

  20. Herring AB, Urich H: Sarcoidosis of the central nervous system. J Neurol Sci 9:405, 1969.

    Article  PubMed  CAS  Google Scholar 

  21. Pennell WH: Boeck’s sarcoid with involvement of the central nervous system. Arch Neurol 66:728, 1951.

    CAS  Google Scholar 

  22. Vesely DL, Maldonodo A, Levey GS: Partial hypopituitarism and possible hypothalamic involvement in sarcoidosis: Report of a case and review of the literature. Am J Med 62:425, 1977.

    Article  PubMed  CAS  Google Scholar 

  23. Stuart CA, Neelon FA, Lebovitz HE: Hypothalamic insufficiency: The cause of hypopituitarism in sarcoidosis. Ann Intern Med 88:589, 1978.

    PubMed  CAS  Google Scholar 

  24. Pelkonen R, Kuusisto A, Salmi J, et al: Pituitary function after pituitary apoplexy. Am J Med 65:773, 1978.

    Article  PubMed  CAS  Google Scholar 

  25. Veldhuis JD, Hammond JM: Endocrine function after spontaneous infarction of the human pituitary: Report, review, and reappraisal. Endocr Rev 1:100, 1980.

    Article  PubMed  CAS  Google Scholar 

  26. Conomy JP, Ferguson JH, Brodkey JS: Spontaneous infarction in pituitary tumors: Neurologic and therapeutic aspects. Neurology (NY) 25:580, 1975.

    CAS  Google Scholar 

  27. Gebel P: Pituitary apoplexy: Review of literature with a report of an unusual case associated with diabetes insipidus. Milit Med 127:753, 1962.

    CAS  Google Scholar 

  28. Cardoso ER, Peterson EW: Pituitary apoplexy: A review. Neurosurgery 14:363, 1984.

    Article  PubMed  CAS  Google Scholar 

  29. Merker E, Futterweit W: Postpartum amenorrhea, diabetes insipidus and galactorrhea: Report of a case and review of the literature. Am J Med 56:554, 1974.

    Article  PubMed  CAS  Google Scholar 

  30. Doxiades T, Tiliakos M: Diabetes insipidus in association with postpartum hypopituitarism Br Med J 1:23, 1956.

    Article  PubMed  CAS  Google Scholar 

  31. Evans HW: Sheehan’s syndrome with diabetes insipidus. Am J Med 28:648, 1960.

    Article  PubMed  CAS  Google Scholar 

  32. Ahn CS, Kim DS: Sheehan’s syndrome associated with diabetes insipidus. Lancet 2:1045, 1964.

    Article  PubMed  CAS  Google Scholar 

  33. Aguilo F, Vega LA, Haddock L, et al: Diabetes insipidus syndrome in hypopituitarism of pregnancy. Acta Endocrinol (Kbh) 60(suppl):137–H, 1969.

    Google Scholar 

  34. Spain AW, Geoghehan F: Diabetes insipidus in association with postpartum pituitary necrosis. J Obstet Gynaecol Br Commonw 53:223, 1946.

    Article  CAS  Google Scholar 

  35. Schwartz AR, Leddy AL: Recognition of diabetes insipidus in postpartum hypopituitarism. Obstet Gynecol 59:394, 1982.

    PubMed  CAS  Google Scholar 

  36. Sheehan HL, Whitehead R: The neurohypophysis in post-partum hypopituitarism. J Pathol 85:145, 1963.

    Article  CAS  Google Scholar 

  37. Whitehead R: The hypothalamus in post-partum hypopituitarism. J Pathol 86:55, 1963.

    Article  CAS  Google Scholar 

  38. Bode HH, Crawford JD: Nephrogenic diabetes insipidus in North America: The Hopewell hypothesis. N Engl J Med 280:750, 1969.

    Article  PubMed  CAS  Google Scholar 

  39. Barron WM, Cohen LH, Ulland LA, et al: Transient vasopressin-resistant diabetes insipidus of pregnancy. N Engl J Med 310:442, 1984.

    Article  PubMed  CAS  Google Scholar 

  40. Kleeman CR, Czaczkes JW, Cutler R: Mechanisms of impaired water excretion in adrenal and pituitary insufficiency. IV. Antidiuretic hormone in primary and secondary adrenal insufficiency. J Clin Invest 43:1641, 1964.

    Article  PubMed  CAS  Google Scholar 

  41. Robson JS, Lambie AT: Cortisone-induced polyuria following hypophysectomy. Am J Med 26:769, 1959.

    Article  PubMed  CAS  Google Scholar 

  42. Danguir J: Sleep deficits in rats with hereditary diabetes insipidus. Nature (Lond) 304:163, 1983.

    Article  CAS  Google Scholar 

  43. Laczi F, van Ree JM, Wagner A, et al: Effects of desglycinamide-arginine-vasopressin (DGAVP) on memory processes in diabetes insipidus patients and non-diabetic subjects. Acta Endocrinol (Copenh) 102:205, 1983.

    CAS  Google Scholar 

  44. Miller M. Dalakos T, Moses AM, et al: Recognition of partial defects in antidiuretic hormone secretion. Ann Intern Med 73:721, 1970.

    PubMed  CAS  Google Scholar 

  45. Weitzman RE, Kleeman CR: The clinical physiology of water metabolism. Part II. Renal mechanisms for urinary concentration; diabetes insipidus. West J Med 131:486, 1979.

    PubMed  CAS  Google Scholar 

  46. Halter JB, Goldberg AP, Robertson GL, et al: Selective osmoreceptor dysfunction in the syndrome of chronic hypernatremia. J Clin Endocrinol Metab 44:609, 1977.

    Article  PubMed  CAS  Google Scholar 

  47. Avioli LV, Earley LE, Kashima HK: Chronic and sustained hypernatremia, absence of thirst, diabetes insipidus, and adrenocorticotropin insufficiency resulting from widespread destruction of the hypothalamus. Ann Intern Med 56:131, 1982.

    Google Scholar 

  48. De Rubertis FR: Michelis MF, Davis BB: Essential hypernatremia. Arch Intern Med 134:889, 1974.

    Article  Google Scholar 

  49. Brezis M, Weiler-Ravell D: Hypernatremia, hypodipsia and partial diabetes insipidus: A model for defective osmoregulation. Am J Med Sci 279:37, 1980.

    Article  PubMed  CAS  Google Scholar 

  50. Gill G, Baylis P, Burn J: A case of‘essential’ hypernatraemia due to resetting of the osmostat. Clin Endocrinol (Oxf) 22:545, 1985.

    Article  CAS  Google Scholar 

  51. Dunger DB, Lightman S, Williams M, et al: Lack of thirst, osmoreceptor dysfunction, early puberty and abnormally aggressive behaviour in two boys. Clin Endocrinol (Oxf) 22:469, 1985.

    Article  CAS  Google Scholar 

  52. Alford FP, Scoggins BA, Wharton C: Symptomatic normovolemic essential hypertension. Am J Med 54:359, 1973.

    Article  PubMed  CAS  Google Scholar 

  53. Leaf A, Mamby AR, Ramussen H, et al: Some hormonal aspects of water extraction in man. J Clin Invest 31:914, 1952.

    Article  PubMed  CAS  Google Scholar 

  54. Kastin AJ, Lipsett MB, Ommaya AK, et al: Asymptomatic hypernatremia, physiological and clinical study. Am J Med 38:306, 1965.

    Article  PubMed  CAS  Google Scholar 

  55. Zazgornik J, Jellinger K, Waldhausal W, et al: Excessive hypernatraemia and hyperosmolality associated with a germinoma in the hypothalamic and pituitary regions. Eur Neurol 12:38, 1974.

    Article  PubMed  CAS  Google Scholar 

  56. Mahoney JH, Goodman AD: Hypernatremia due to hypodysplasia and elevated threshold for vasopressin release. N Engl J Med 279:1191, 1968.

    Article  PubMed  CAS  Google Scholar 

  57. Pleasure D, Goldberg M: Neurogenic Hypernatremia. Arch Neurol 15:78, 1966.

    PubMed  CAS  Google Scholar 

  58. Schaffblass S, Robertson GL, Rosenfield RL, et al: Chronic hypernatremia from a congenital defect in osmoregulation of thirst and vasopressin. J Pediatr 102:703, 1983.

    Article  CAS  Google Scholar 

  59. Bannister P, Sheridan P, Penney MD: Chronic reset osmoreceptor response, agenesis of the corpus callosum and hypothalamic cyst. J Pediatr 104:97, 1984.

    Article  PubMed  CAS  Google Scholar 

  60. Wise BL: Neurogenic hyperosomolality (hypernatremia). Neurology (NY) 12:453, 1962.

    CAS  Google Scholar 

  61. Hickey RC, Hare K: The renal excretion of chloride and water in diabetes insipidus. J Clin Invest 23:768, 1944.

    Article  PubMed  CAS  Google Scholar 

  62. Moses AM, Streeten DHP: Differentiation of polyuric states by measurement of responses to changes in plasma osmolality induced by hypertonic saline infusions. Am J Med 42:368, 1967.

    Article  PubMed  CAS  Google Scholar 

  63. Moses AM, Notman DD: Diabetes insipidus and syndrome of inappropriate antidiuretic hormone secretion (SIADH). Adv Intern Med 27:73, 1982.

    PubMed  CAS  Google Scholar 

  64. DeRubertis FR, Michelis MF, Beck N, et al: “Essential” hypernatremia due to ineffective osmotic and intact volume regulation of vasopressin secretion. J Clin Invest 50:97, 1971.

    Article  PubMed  CAS  Google Scholar 

  65. Goldberg M, Weinstein G, Adesman J, et al: Asymptomatic hypovolemic hypernatremia, a variant of essential hypernatremia. Am J Med 43:804, 1967.

    Article  PubMed  CAS  Google Scholar 

  66. Robertson GL: Immunoassay of plasma vasopressin in man. Proc Natl Acad Sci USA 66:1298, 1970.

    Article  PubMed  CAS  Google Scholar 

  67. Beardwell CG: Radioimmunoassay of arginine vasopressin in human plasma. J Clin Endocrinol Metab 33:254, 1971.

    Article  PubMed  CAS  Google Scholar 

  68. Zerbe RL, Robertson GL: A comparison of plasma vasopressin measurements with a standard indirect test in the differential diagnosis of polyuria. N Engl J Med 305:1539, 1981.

    Article  PubMed  CAS  Google Scholar 

  69. Mellinger RC, Zafar MS: Primary polydipsia: Syndrome of inappropriate thirst. Arch Intern Med 143:1249, 1983.

    Article  PubMed  CAS  Google Scholar 

  70. Vavra G, Machova A, Holecek V: Effect of synthetic analogue of vasopressin in animals and in patients with diabetes insipidus. Lancet 1:948, 1968.

    Article  PubMed  CAS  Google Scholar 

  71. Robinson AG: DDAVP in the treatment of diabetes insipidus. N Engl J Med 294:507, 1976.

    Article  PubMed  CAS  Google Scholar 

  72. Lee WP, Lippe BM, La Franchi SH, et al: Vasopressin analog DDAVP in the treatment of diabetes insipidus. Am J Dis Child 130:166, 1976.

    PubMed  CAS  Google Scholar 

  73. Richardson DW, Robinson AG: Desmopressin. Ann Intern Med 103:228, 1985.

    PubMed  CAS  Google Scholar 

  74. Kunstadter RH, Cabana EC, Oh W: Treatment of vasopressin-sensitive diabetes insipidus with chlorpropamide. Am J Dis Child 117:436, 1969.

    PubMed  CAS  Google Scholar 

  75. Vallet HL, Prasad M, Goldbloom RB: Chlorpropamide treatment of diabetes insipidus in children. Pediatrics 45:246, 1970.

    PubMed  CAS  Google Scholar 

  76. Webster B, Bain J: Antidiuretic effect and complications of chlorpropamide therapy in diabetes insipidus. J Clin Endocrinol Metab 30:215, 1970.

    Article  PubMed  CAS  Google Scholar 

  77. Miller M, Moses AM: Mechanism of chlorpropamide action in diabetes insipidus. J Clin Endocrinol Metab 30:488, 1970.

    Article  PubMed  CAS  Google Scholar 

  78. Berndt WO, Miller M, Kettyle WM, et al: Potentiation of the antidiuretic effect of vasopressin by chlorpropamide. Endocrinology 86:1028, 1970.

    Article  PubMed  CAS  Google Scholar 

  79. Ingelfinger JR, Hays RA: Evidence that chlorpropamide and vasopressin share a common site of action. J Clin Endocrinol Metab 29:738, 1969.

    Article  PubMed  CAS  Google Scholar 

  80. Brooker G, Fichman M: Chlorpropamide and tolbutamide inhibition of adenosine 3′5′-cyclic monophosphate phosphodiesterase. Biochem Biophys Res Commun 42:824, 1971.

    Article  PubMed  CAS  Google Scholar 

  81. Zusman RM, Keiser HR, Handler JS: A hypothesis for the molecular mechanism of action of chlorpropamide in the treatment of diabetes mellitus and diabetes insipidus. Fed Proc 36:2728, 1977.

    PubMed  CAS  Google Scholar 

  82. Moses AM, Howanitz J, Van Gemert M, et al: Clofibrate induced antidiuresis. J Clin Invest 52:535, 1973.

    Article  PubMed  CAS  Google Scholar 

  83. Kimura T, Matsui K, Sato T, et al: Mechanism of carbamazepine (Tegretol) induced antidiuresis: Evidence for release of antidiuretic hormone and impaired excretion of a water load. J Clin Endocrinol Metab 38:356, 1974.

    Article  PubMed  CAS  Google Scholar 

  84. Crawford JD, Kennedy G: Chlorothiazide in diabetes insipidus. Nature (Lond) 183:891, 1959.

    Article  CAS  Google Scholar 

  85. Batlle DC, von Riotte AB, Gaviria M, et al: Amelioration of polyuria by amiloride in patients receiving long-term lithium therapy. N Engl J Med 312:408, 1985.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Endocrinology and Metabolism Department of Medicine, Cook County Hospital, Chicago, Illinois, USA

    C. R. Kannan M.D. (Chairman, Clinical Associate Professor of Medicine)

  2. University of Illinois at Chicago, Chicago, Illinois, USA

    C. R. Kannan M.D. (Chairman, Clinical Associate Professor of Medicine)

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  1. C. R. Kannan M.D.
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© 1987 Plenum Publishing Corporation

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Kannan, C.R. (1987). Diabetes Insipidus. In: The Pituitary Gland. Clinical Surveys in Endocrinology, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1849-1_20

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  • DOI: https://doi.org/10.1007/978-1-4613-1849-1_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9032-2

  • Online ISBN: 978-1-4613-1849-1

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