Comparative Genetic Analysis of Homeobox Genes in Mouse and Man

  • Frank H. Ruddle
  • Charles P. Hart
  • Mark Rabin
  • Anne Ferguson-Smith
  • Dimitrina Pravtcheva
Part of the New Horizons in Therapeutics book series (NHTH)


Homeobox sequences in insects have been described as repetitive elements in homeotic genes (McGinnis et al., 1984a). They have also been found in other genes that have developmental functions. The homeobox sequences are conserved in many animal groups across the protostome and deuterostome lineages of evolutionary ascent. Highly conserved homeobox sequences have been described in numerous vertebrates, including amphibians and mammals (McGinnis et al., 1984b). We have been especially concerned with homeobox sequences in the mouse and in man (McGinnis et al., 1984c). It is now certain that the homeobox sequences code domains within functional genes in vertebrates, on the basis of their expression in polyadenylated RNA transcripts (Hart et al., 1985). Moreover, the tissue-specific expression and temporal patterns of expression are both consistent with a developmental role (Awgulewitsch et al., 1986).


Homeobox Gene Mouse Chromosome Homeotic Gene Bithorax Complex Comparative Genetic Analysis 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Frank H. Ruddle
    • 1
  • Charles P. Hart
    • 1
  • Mark Rabin
    • 1
  • Anne Ferguson-Smith
    • 1
  • Dimitrina Pravtcheva
    • 1
  1. 1.Department of BiologyYale UniversityNew HavenUSA

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