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Comparative Genetic Analysis of Homeobox Genes in Mouse and Man

  • Frank H. Ruddle
  • Charles P. Hart
  • Mark Rabin
  • Anne Ferguson-Smith
  • Dimitrina Pravtcheva
Part of the New Horizons in Therapeutics book series (NHTH)

Abstract

Homeobox sequences in insects have been described as repetitive elements in homeotic genes (McGinnis et al., 1984a). They have also been found in other genes that have developmental functions. The homeobox sequences are conserved in many animal groups across the protostome and deuterostome lineages of evolutionary ascent. Highly conserved homeobox sequences have been described in numerous vertebrates, including amphibians and mammals (McGinnis et al., 1984b). We have been especially concerned with homeobox sequences in the mouse and in man (McGinnis et al., 1984c). It is now certain that the homeobox sequences code domains within functional genes in vertebrates, on the basis of their expression in polyadenylated RNA transcripts (Hart et al., 1985). Moreover, the tissue-specific expression and temporal patterns of expression are both consistent with a developmental role (Awgulewitsch et al., 1986).

Keywords

Homeobox Gene Mouse Chromosome Homeotic Gene Bithorax Complex Comparative Genetic Analysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Awgulewitsch, A., Utset, M. F., Hart, C. P., McGinnis, W., and Ruddle, F. H., 1986, Spatial restriction in expression of a mouse homeobox locus within the central nervous system, Nature (London) 320:328–335.CrossRefGoogle Scholar
  2. Casey, G., Smith, R., McGillivray, D., Peters, G., and Dickson, C., 1986, Characterization and chromosome assignment of the human homolog of int-2, a potential proto-oncogene, Mol. Cell. Biol. 6:502–510.PubMedGoogle Scholar
  3. Chambon, P., Green, S., Walter, P., Kumar, V., Krust, A., Bornert, J., and Bonner, D., 1986, Steroid hormone receptor genes: Cloning, organization, and expression, ISCU Newsletter 4:246–249.Google Scholar
  4. De la Chapelle, A., 1985, Human gene mapping 8, Cytogenet. Cell Genet. 40(1-4):1–823.PubMedCrossRefGoogle Scholar
  5. Desplan, C., Theis, J., and O’Farrell, P., 1985, The Drosophila developmental gene,engrailed, encodes a sequence-specific DNA binding activity, Nature (London) 318:630–635.CrossRefGoogle Scholar
  6. Green, M. C., 1981, Genetic Variants and Strains of the Laboratory Mouse ,Gustav Fischer Verlag, Stuttgart.Google Scholar
  7. Hart, C. P., Awgulewitsch, F., Fainsod, A., McGinnis, W., and Ruddle, F. H., 1985, Homeo-box gene complex on mouse chromosome 11: Molecular cloning, expression in embryogenesis and homology to a human homeo-box locus, Cell 43:9–18.PubMedCrossRefGoogle Scholar
  8. Huebner, K., Isobe, M., Chao, M., Bothwell, M., Ross, A., Finan, J., Hoxie, J., Seghal, A., Buck, C. R., Lanahan, A., Nowell, P., Koprowski, H., and Croce, C., 1986, The nerve growth factor receptor gene is at human chromosome region 17q12-17q22, distal to the chromosome 17 breakpoint in acute leukemias, Proc. Natl. Acad. Sci. U.S.A. 83:1403–1407.PubMedCrossRefGoogle Scholar
  9. Jansson, J.-O., Downs, T., Beamer, W., and Frohman, L., 1986, Receptor-association resistance to growth hormone-releasing factor in dwarf “little” mice, Science 232:511–512.PubMedCrossRefGoogle Scholar
  10. Joyner, A. L., Romberg, T., Coleman, K. G., Cox, D. R., and Martin, G. R., 1985a, Expression during embryogenesis of a mouse gene with sequence homology to the Drosophila engrailed gene, Cell 43:29–37.PubMedCrossRefGoogle Scholar
  11. Joyner, A. L., Hauser, C., Kornberg, T., Tjian, R., and Martin, G., 1985b, Structure and expression of two classes of Mammalian homeo-box-containing genes, Cold Spring Harbor Symp. Quant. Biol. 50:291–300.PubMedGoogle Scholar
  12. Killary, A., and Fournier, R., 1984, A genetic analysis of extinction: Trans-dominant loci regulate expression of liver-specific traits in hepatoma hybrid cells, Cell 38:523–534.PubMedCrossRefGoogle Scholar
  13. Laughon, A., and Scott, M. P., 1984, Sequence of a Drosophila segmentation gene: Protein structure homology with DNA binding proteins, Nature (London) 310:25–31.CrossRefGoogle Scholar
  14. Lewis, E. B., 1985, Regulation of the genes of the bithorax complex in Drosophila ,in: Banbury Report 20: Genetic Manipulations of the Early mammalian Embryos (F. Costantini and R. Jaenisch, eds.), Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, pp. 155–164.Google Scholar
  15. McGinnis, W., Levine, M., Hafen, E., Kuroiwa, A., and Gehring, W. J., 1984a, A conserved DNA sequence in homeotic genes of the Drosophila antennapedia and bithorax complexes, Nature (London) 308:428–433.CrossRefGoogle Scholar
  16. McGinnis, W., Garber, R. L., Witz, J., Kuroiwa, A., and Gehring, W. J., 1984b, A homologous protein-coding sequence in Drosophila homeotic genes and its conservation to other metazoans, Cell 37:408–412.CrossRefGoogle Scholar
  17. McGinnis, W., Hart, C. P., Gehring, W. J., and Ruddle, F. H., 1984c, Molecular cloning and chromosome mapping of a mouse DNA sequence homologous to homeotic genes of Drosophila, Cell 38:675–680.PubMedCrossRefGoogle Scholar
  18. Michael, S. K., Hilger, J., Kozak, C., Whitney, J. B. III, and Howard, E. F., 1986, Characterization and mapping of DNA sequence homologous to mouse Ulal snRNA: Localization on chromosome 11 near the Dlb-1 and Re loci, Somat. Cell Mol. Genet. 12(3):215–223.PubMedCrossRefGoogle Scholar
  19. Moore, R., Casey, G., Brookes, S., Dixon, M., Peters, G., and Dickson, C, 1986, Sequence, topography and protein coding potential of mouse int-2: A putative oncogene activated by mouse mammary tumor virus, Eur. Mol. Biol. Org. J. 5:919–924.Google Scholar
  20. Petit, C., Levilliers, J., Ott, M.-O., and Weiss, M., 1986, Tissue-specific expression of the rat albumin gene: Genetic control of its extinction in microcell hybrids, Proc. Natl. Acad. Sci. U.S.A. 83:2561–2565.PubMedCrossRefGoogle Scholar
  21. Pravtcheva, D., Rabin, M., Bartolomei, M., Gorden, J., and Ruddle, F. H., 1986, Chromosomal assignment of the gene encoding the largest subunit of RNA polymerase II in the mouse, Somat. All. Mol. Genet. (in press).Google Scholar
  22. Rabin, M., Hart, C. P., Ferguson-Smith, A., McGinnis, W., Levine, M., and Ruddle, F. H., 1985, Two homeobox loci mapped in evolutionary related mouse human chromosomes, Nature (London) 314:175–178.CrossRefGoogle Scholar
  23. Rabin, M., Ferguson-Smith, A., Hart, C.P., and Ruddle, F. H., 1986, Cognate homeobox loci mapped on homologous human and mouse chromosomes, Proc. Natl. Acad. Sci. U.S.A. (in press).Google Scholar
  24. Rehfeld, J. F., 1981, Four basic characteristics of the gastrin-cholecystokinin system, Am. J. Physiol. 240:G255–G266.PubMedGoogle Scholar
  25. Ruddle, F. H., Hart, C. P., Awgulewitsch, A., Fainsod, A., Utset, M., Dalton, D., Kerk, N., Rabin, M., Ferguson-Smith, A., Fienberg, A., and McGinnis, W., 1985a, Mammalian homeo box genes, Cold Spring Harbor Symp. Quant. Biol. 50:277–284.PubMedGoogle Scholar
  26. Ruddle, F. H., Hart, C. P., and McGinnis, W., 1985b, Homeo-box sequences-relevant vertebrate developmental mechanisms, Banbury Report 20: Genetic Manipulations of the Early Mammalian Embryo (F. Costantini and R. Jaenisch, eds.), Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, pp. 169–177.Google Scholar
  27. Shepherd, J. C. W., McGinnis, W., Carrasco, A. E., DeRobertis, E. M., and Gehring, W. J., 1984, Fly and frog homeo domains show homologies with yeast mating type regulatory proteins, Nature (London) 310:70–72.CrossRefGoogle Scholar
  28. Somssich, I., Spira, J., Hameister, H., and Klein, G., 1984, Correlation between tumorigenicity and banding patterns of chromosome 15 in murine T-cell leukemia cells and hybrids of normal and malignant cells, Chromosoma 91:39–45.PubMedCrossRefGoogle Scholar
  29. Yamamoto, T., Ikawa, S., Akiyama, T., Semba, K., Nomura, N., Miyajima, N., Saito, T., and Toyoshima, K., 1986, Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor, Nature (London) 319:230–231.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Frank H. Ruddle
    • 1
  • Charles P. Hart
    • 1
  • Mark Rabin
    • 1
  • Anne Ferguson-Smith
    • 1
  • Dimitrina Pravtcheva
    • 1
  1. 1.Department of BiologyYale UniversityNew HavenUSA

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