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The Relationship between the Vitamin D System and Cancer

  • Hector F. DeLuca
  • Voula Ostrem

Abstract

The classic function of 1,25-dihydroxyvitamin D3, the hormonally active form of vitamin D, is the maintenance of normal levels of calcium and phosphorus in the blood. 1,25-Dihydroxyvitamin D3 binds to a specific receptor protein and exerts its biologic action by a mechanism analogous to that proposed for other steroid hormones, that is, the receptor-ligand complex acts on the chromatin to induce transcription of specific genes. Intracellular receptors that bind 1,25-dihydroxyvitamin D3 with high affinity have been found in a large number of tumor cell lines examined as melanoma, osteosarcoma, and human breast and colonic carcinoma cells. The 1,25-dihydroxyvitamin D3 receptor in these cells has characteristics similar to the receptor in bone and intestine, the known target tissues of the hormone. In fact, 1,25-dihydroxyvitamin D3 inhibits the proliferation of melanoma, osteosarcoma, and breast carcinoma cells. More recently, 1,25-dihydroxyvitamin D3 has been shown to suppress the growth and induce monocytic differentiation of murine and human myeloid leukemia cells in vitro. These results point to a previously unsuspected involvement of vitamin D in cell proliferation and differentiation and suggest that analogs of the vitamin D hormone may be of interest as possible therapeutic agents in the treatment of malignancy.

Keywords

Parathyroid Gland Myeloid Leukemia Cell Human Breast Carcinoma Cell Human Myeloid Leukemia Cell Intestinal Calcium Transport 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

25-OH-D3

25-hydroxyvitamin D3

1,25-(OH)2D3

1α, 25-dihydroxyvitamin D3

TPA

12-O-tetradecanoylphorbol-13-acetate

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Hector F. DeLuca
    • 1
  • Voula Ostrem
    • 1
  1. 1.Department of Biochemistry, College of Agricultural and Life SciencesUniversity of Wisconsin-MadisonMadisonUSA

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