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Role of Tryptophan in Carcinogenesis

  • Chapter
Essential Nutrients in Carcinogenesis

Abstract

This paper reviews some of the earlier experimental studies concerning the role that tryptophan plays in enhancing tumorigenesis induced by selected chemical carcinogens. For many years, tryptophan has been implicated in carcinogenesis of the bladder. The evidence regarding tryptophan’s effect on hepatic tumorigenesis is conflicting; an enhancing effect has been reported by some investigators, but a reduction in tumorigenesis has been reported by other workers. Some of the unique effects that tryptophan exerts upon the liver are reviewed. Also, experimental studies from our laboratory are reported in which we observed a potentiating effect of increased dietary tryptophan on the induction of γ-glutamyltranspeptidase-positive foci in liver when rats were fed a choline-supplemented diet but no potentiation was found when rats were fed a choline-deficient diet for 10 weeks. The results suggest that increased dietary tryptophan has a promoting effect on liver carcinogenesis as measured by the induction of γ-glutamyltranspeptidase-positive foci in the livers of rats exposed to diethylnitrosamine. The possible significance of these findings is reviewed.

Supported in part by Public Health Service grants CA-26557 from the National Cancer Institute and AM-27339 from the National Institute of Arthritis, Diabetes and Digestive and Kidney Diseases.

I gratefully acknowledge the collaborative efforts of E. Verney, C. N. Murty, D. S. R. Sarma, C. T. Garrett, M. Bongiorno, R. Hornseth, E. S. Robinson, and E. Meyers in the experimental work presented from this laboratory.

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Abbreviations

NTPase:

nucleoside triphosphatase

Con A:

concanavalin A

FANFT:

N-[4-(5-nitro-2-furyl)-2-thiazoyl]formamide

BHBN:

N-butyl-N-(4-hydroxybutyl)-nitrosamine

Trp-P-1:

3-aminol,4-dimethyl-5H-pyrido [4,3-b]indole

Trp-P-2:

3-amino-methyl-5H-pyrido [4,3-b]indole

DEN:

diethylnitrosamine

GGT:

γ-glutamyltranspeptidase

CS:

choline supplemented

CD:

choline deficient

ODC:

ornithine decarboxylase

SAM:

S-adenosylmethionine

GSH:

glutathione

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Authors and Affiliations

  1. Department of Pathology, The George Washington University Medical Center, 2300 Eye Street, N.W., Washington, D.C., 20037, USA

    Herschel Sidransky

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  1. Herschel Sidransky
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  1. Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick Cancer Research Facility, Frederick, Maryland, USA

    Lionel A. Poirier

  2. Department of Pathology, Boston University School of Medicine, Boston, Massachusetts, USA

    Paul M. Newberne

  3. Food Research Institute, University of Wisconsin, Madison, Wisconsin, USA

    Michael W. Pariza

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© 1986 Plenum Press, New York

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Sidransky, H. (1986). Role of Tryptophan in Carcinogenesis. In: Poirier, L.A., Newberne, P.M., Pariza, M.W. (eds) Essential Nutrients in Carcinogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1835-4_16

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  • DOI: https://doi.org/10.1007/978-1-4613-1835-4_16

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