Abstract
An ethylene/methacrylic acid copolymer was used to study the influence of sodium neutralization on blood/material interactions in a canine intra-arterial model. Material properties evaluated were sodium concentration, thermal characteristics, surface morphology, surface energy, surface clustering of the methacrylate component, hydrophilicity, sodium release, and acid group dissociation. The surface properties of the polyethylene control, 0% Na, and 50% Na samples tended to be similar; these properties were different from the 100% Na sample. The 100% Na ionomer was more hydrophilic, it had a higher polar component for its surface energy, and it was unique in exhibiting discrete anionic clusters 1 to 10 µm in diameter on its surface. These differences were manifested in vivo by platelet aggregation and thrombus formation on the polyethylene, 0% Na, and 50% Na implants, while the 100% Na implants’surface was predominately covered by singly adherent platelets. It is proposed that the lower levels of thrombus formation on the 100% Na ionomer are due to the cluster development in the neutralized methacrylic component. These cluster regions are polar and hydrophilic.
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Goggins, J.A., Hiltner, A., Jones, R.D. (1987). Sodium Neutralization in a Polyethylene Ionomer and Blood/Material Interactions in an In Vivo Canine Model. In: Gebelein, C.G. (eds) Advances in Biomedical Polymers. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1829-3_20
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DOI: https://doi.org/10.1007/978-1-4613-1829-3_20
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