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Regeneration of Sciatic Nerve Across 15mm Gap by Use of a Polymeric Template

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Advances in Biomedical Polymers

Abstract

A porous biodegradable collagen-glycosaminoglycan bridge induced regeneration of myelinated and unmyelinated axons over large distances (15 mm) between the severed ends of the adult rat sciatic nerve. The newly formed strand of nerve tissue was well vascularized and sheathed in connective tissue 6 weeks following implantation of the polymeric guide. Nerve tissue did not grow in the absence of the polymeric guide.

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Author information

Authors and Affiliations

  1. Fibers and Polymers Laboratories, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA

    I. V. Yannas & D. P. Orgill

  2. Department of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA

    J. Silver

  3. Massachusetts General Hospital, Boston, MA, 02114, USA

    T. V. Norregaard & N. T. Zervas

  4. Department of Pathology (Neuropathology), Brigham and Women’s Hospital, Boston, MA, 02114, USA

    W. C. Schoene

Authors
  1. I. V. Yannas
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  2. D. P. Orgill
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  3. J. Silver
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  4. T. V. Norregaard
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  5. N. T. Zervas
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  6. W. C. Schoene
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Editor information

Editors and Affiliations

  1. Department of Chemistry, Youngstown State University, Youngstown, Ohio, 44555, USA

    Charles G. Gebelein

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© 1987 Plenum Press, New York

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Yannas, I.V., Orgill, D.P., Silver, J., Norregaard, T.V., Zervas, N.T., Schoene, W.C. (1987). Regeneration of Sciatic Nerve Across 15mm Gap by Use of a Polymeric Template. In: Gebelein, C.G. (eds) Advances in Biomedical Polymers. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1829-3_1

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  • DOI: https://doi.org/10.1007/978-1-4613-1829-3_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9022-3

  • Online ISBN: 978-1-4613-1829-3

  • eBook Packages: Springer Book Archive

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