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Neuropeptides and Memory

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Handbook of Psychopharmacology

Abstract

Some of the earliest evidence suggesting a behavioral role for peptides came from studies of pituitary-adrenal function. For example, De Wied and others demonstrated that the behavioral effects produced by removal of the pituitary could be reversed by adrenocorticotropin hormone (ACTH) and other peptides, such as vasopressin (AVP) (De Wied, 1980). Later work established that these peptides could produce profound effects on extinction of learned responses in normal animals even with synthetic analogs reputedly devoid of endocrinological activity. Variously interpreted as actions on attention (ACTH) or on memory consolidation (AVP), these effects were hypothesized to be mediated via some neural substrate. Where this substrate is located and how these pituitary-derived peptides normally interact with it remain largely unknown.

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Authors and Affiliations

  1. Division of Preclinical Neuroscience and Endocrinology, Scripps Clinic and Research Foundation, La Jolla, California, 92037, USA

    George F. Koob

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  1. George F. Koob
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  1. Department of Psychology, University of Cambridge, USA

    Leslie L. Iversen  & Susan D. Iversen  & 

  2. Departments of Neuroscience, Pharmacology, and Psychiatry, The Johns Hopkins University School of Medicine, USA

    Solomon H. Snyder

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© 1987 Plenum Press, New York

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Koob, G.F. (1987). Neuropeptides and Memory. In: Iversen, L.L., Iversen, S.D., Snyder, S.H. (eds) Handbook of Psychopharmacology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1819-4_9

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  • DOI: https://doi.org/10.1007/978-1-4613-1819-4_9

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