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Psychopharmacology of Nicotine: Stimulus Effects and Receptor Mechanisms

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Handbook of Psychopharmacology

Abstract

The paradoxical status of the pharmacology of nicotinic mechanisms as a research problem has both stimulated and frustrated psychopharmacologists. The paradox is the dissonance between the practical importance of understanding a significant aspect of brain function and the actual amount of interest shown in the problem. People smoke tobacco mainly to obtain the effects of nicotine; a more effective, rational way of dealing with the pharmacological component of tobacco addiction can only come from advances in understanding both the behavioral mechanisms involved and the mode of action of nicotine in the CNS. There is also growing interest in the relation that central nicotinic mechanisms may have to certain pathological states, notably Alzheimer’s disease (in which disturbances in cholinergic systems have been investigated mainly with regard to muscarinic systems) and parkinsonism (which is negatively correlated with cigarette smoking). Why has nicotine research been so much neglected until recent years? This chapter begins with a brief consideration of the reasons for this state of affairs; it then details recent advances made in understanding ways in which nicotine helps to maintain tobacco smoking and in knowledge of relevant CNS mechanisms.

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  1. Departments of Pharmacology and Psychiatry, Institute of Psychiatry, London, SE5 8AF, England

    I. P. Stolerman

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  1. Department of Psychology, University of Cambridge, USA

    Leslie L. Iversen  & Susan D. Iversen  & 

  2. Departments of Neuroscience, Pharmacology, and Psychiatry, The Johns Hopkins University School of Medicine, USA

    Solomon H. Snyder

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Stolerman, I.P. (1987). Psychopharmacology of Nicotine: Stimulus Effects and Receptor Mechanisms. In: Iversen, L.L., Iversen, S.D., Snyder, S.H. (eds) Handbook of Psychopharmacology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1819-4_7

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  • DOI: https://doi.org/10.1007/978-1-4613-1819-4_7

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