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Psychopharmacology of Repeated Seizures: Possible Relevance to the Mechanism of Action of Electroconvulsive Therapy

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Handbook of Psychopharmacology

Abstract

The last few years have seen a marked increase in the research on the biochemical and pharmacological consequences of repeated electroconvulsive shock (ECS), for several reasons. The first reason is that electroconvulsive therapy (ECT) is still acknowledged as the most successful treatment for severe depressive illness (see Brandon et al., 1984: Royal College of Psychiatrists, 1977; Fink, 1979). The second reason is that greater insight has now been gained into the mechanism of action of antidepressant drugs, so it seems reasonable to determine whether the experimental effects of ECS are similar to those of the drugs. The third reason is that ECT remains a controversial treatment, and thus a greater understanding of its mechanism of action may eventually lead to the development of a pharmacological agent with the efficacy of ECT but, it is to be hoped, fewer side effects and less public disquiet.

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References

  • Adams, H. E., Hoblit, P. R., and Sulker, P. D., 1969, Electroconvulsive shock, brain acetylcholinesterase activity and memory, Physiol. Behav. 4: 113–116.

    Google Scholar 

  • Appleyard, M. E., Green, A. R., and Smith, A. D., 1984, Regional acetylcholinesterase activity in rat brain following a convulsion, Br. J. Pharmacol. 82: 248 P.

    Google Scholar 

  • Appleyard, M. E., Green, A. R., and Smith, A. D., 1985, Acetylcholinesterase activity in regions of the rat brain following a convulsion, J. Neurochem. 46: 1789–1793.

    Google Scholar 

  • Atterwill, C. K., 1980, Lack of effect of repeated electroconvulsive shock on [3H]-5-hydroxytryptamine binding and cholinergic parameters in rat brain, J. Neurochem. 35: 729–734.

    PubMed  CAS  Google Scholar 

  • Atterwill, C. K., 1984, The effects of ECS on central cholinergic and interrelated neurotransmitter systems, in: ECT: Basic Mechanisms ( B. Lerer, R. D. Weiner, and R. H. Belmaker, eds.), John Libbey Co., London, pp. 79–88.

    Google Scholar 

  • Atterwill, C. K., and Green, A. R., 1980, Responses of developing rats to L-tryptophan plus an MAOI. II: Effects of repeated electroconvulsive shock, Neuropharmacology 19: 337–341.

    PubMed  CAS  Google Scholar 

  • Atterwill, C. K., Batts, C., and Bloomfield, M. R., 1981, Effect of single and repeated convulsions on glutamate decarboyxlase (GAD) activity and [3H]-muscimol binding in the rat brain, J. Pharm. Pharmacol. 33: 329–331.

    PubMed  CAS  Google Scholar 

  • Atweh, S., Simon, J. R., and Kuhar, J. J., 1976 Utilisation of sodium-dependent high affinity choline uptake in vitro as a measure of the activity of cholinergic neurons in vivo, Life Sci. 17: 1535–1544.

    Google Scholar 

  • Balldin, J., Granerus, A. K., Lindstedt, G., Modigh, K., and Walinder, J., 1982, Neuroendocrine evidence for increased responsiveness of dopamine receptors in humans following electroconvulsive therapy, Psychopharmacology 76: 371–376.

    PubMed  CAS  Google Scholar 

  • Belenky, G. L., and Holaday, J. W., 1979, The opiate antagonist naloxone modifies the effect of electroconvulsive shock (ECS) on respiration, blood pressure and heart rate, Brain Res. 117: 414–417.

    Google Scholar 

  • Belenky, G. L., and Holaday, J. W., 1981, Repeated electroconvulsive shock (ECS) and morphine tolerance: Demonstration of cross-sensitivity in the rat, Life Sci. 29: 553–563.

    PubMed  CAS  Google Scholar 

  • Belenky, G. L., Tortella, F. C., Hitzemann, R. J., and Holaday, J. W., 1984, The role of endorphine systems in the effects of ECS, in: ECT: Basic Mechanisms ( B. Lerer, R. D. Weiner, and R. H. Belmaker, eds.), John Libbey Co., London, pp. 89–97.

    Google Scholar 

  • Belmaker, R. H., Lerer, B., Bannet, J., and Birmaher, B., 1982, The effect of electroconvulsive shock at a clinically equivalent schedule on rat cortical β-adrenoceptors, J. Pharm. Pharmacol. 34: 275.

    PubMed  CAS  Google Scholar 

  • Bergström, D. A., and Kellar, K. J., 1979, Effect of electroconvulsive shock on monoaminergic receptor binding sites in rat brain, Nature 278: 464–466.

    PubMed  Google Scholar 

  • Bertilsson, L., and Costa, E., 1976, Mass-fragmentographic quantification of glutamic acid and ϒ-aminobutyric acid in cerebellar nuclei and sympathetic ganglia of rats, J. Chromatogr. 118: 395–402.

    PubMed  CAS  Google Scholar 

  • Bhavsar, V. H., Dhumal, V. R., and Kelkar, V. V., 1981, The effect of some anti-epilepsy drugs on enhancement of the monoamine-mediated behavioural responses following the administration of electroconvulsive shocks to rats, Eur. J. Pharmacol. 74: 243–247.

    PubMed  CAS  Google Scholar 

  • Bowdler, J. M., and Green, A. R., 1982, Regional rat brain benzodiazepine receptor number and ϒ-aminobutyric acid concentration following a convulsion, Br. J. Pharmacol. 76: 291–298.

    PubMed  CAS  Google Scholar 

  • Bowdler, J. M., Green, A. R., and Rawle, F. C., 1980, Brain and serum calcium concentrations following electroconvulsive shock or bicuculline-induced convulsions in rats, Br. J. Pharmacol. 71: 321–325.

    PubMed  CAS  Google Scholar 

  • Bowdler, J. M., Green, A. R., Minchin, M. C. W., and Nutt, D. J., 1983, Regional GABA concentrations and [3H]-diazepam binding in rat brain following repeated electroconvulsive shock, J. Neural Transm. 56: 3–12.

    PubMed  CAS  Google Scholar 

  • Bowery, N.G., Hill, D.R., Hudson, A.L., Doble, A., Middlemiss, D.N., Shaw, J., and Turnbull, M., 1980, (-)-Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor, Nature 283: 92–94

    PubMed  CAS  Google Scholar 

  • Brandon, S., Cowley, P., Mcdonald, C., Neville, P., Palmer, R., and Wellstood-Eason, S., 1984, Electroconvulsive therapy: Results in depressive illness from the Leicestershire trial, Br. Med. J. 188: 22–25.

    Google Scholar 

  • Brunello, N., Barbaccia, M. L., Chuang, D. M., and Costa, E., 1982, Down-regulation of β-adrenergic receptors following repeated injections of desmethylimipramine: Permissive role of serotonergic axons, Neuropharmacology 21: 1145–1149.

    PubMed  CAS  Google Scholar 

  • Carman, J. S., and Wyatt, R. J., 1977, Alterations in cerebrospinal fluid and serum total calcium with changes in psychiatric state, in: Neuroregulators and Psychiatric Disorders ( E. Usdin, D. Hamburg, and J. Barchas, eds.), Oxford University Press, New York, pp. 488–494.

    Google Scholar 

  • Carman, J. S., Post, R. M., Goodwin, F. K., and Bunney, W. E., 1977, Calcium and electroconvulsive therapy of severe depressive illness, Biol. Psychiatry 12: 5–17.

    PubMed  CAS  Google Scholar 

  • Chapman, A. G., 1981, Free fatty acid release and metabolism of adenosine and cyclic nucleotides during prolonged seizures, in: Neurotransmitters, Seizures and Epilepsy ( P. L. Morselli, P. G. Lloyd, W. Löscher, B. Meldrum, and E. H. Reynolds, eds.) Raven Press, New York, pp. 165–173.

    Google Scholar 

  • Checkley, S. A., Slade, A. P., and Shur, E., 1981, Growth hormone and other response to clonidine in patients with endogenous depression, Br. J. Psychiatry 138: 51–55.

    PubMed  CAS  Google Scholar 

  • Checkley, S. A., Meldrum, B. S., and Mcwilliam. J. R., 1984. Mechanisms of action of ECT: Neuroendocrine studies, in: ECT: Basic Mechanisms (B. Lerer, R. D. Weiner, and R. H. Belmaker, eds.), John Libbey 8c Co., London, pp. 101–106.

    Google Scholar 

  • Chiodo, L. A., and Antelman, S. M., 1980, Electroconvulsive shock: progressive dopamine autoreceptor subsensitivity independent of repeated treatment, Science 210: 799–801.

    PubMed  CAS  Google Scholar 

  • Christie, J. E., Whalley, L. J., Brown, N. S., et al, 1982, Effect of ECT on the neuroendocrine response to apomorphine in severely depressed patients, Br. J. Psychiatry 140: 268–273.

    PubMed  CAS  Google Scholar 

  • Costa, E., 1979, The role of gamma-amino butyric acid in the action of 1, 4-benzodiazepines, Trends Pharm. Sci. 1: 41–45.

    CAS  Google Scholar 

  • Costa, E., and Barbaccia, M. L., 1984, Regulation of 5-hydroxy-tryptamine (5-HT) uptake: Endocoid modulators and the action of imipramine, in: Proceedings of the 9th International Congress of Pharmacology, Vol. 3 ( W.D.M. Paton, J. F. Mitchell, and P. Turner, eds.), Macmillan Press, Basingstoke, England, pp. 109–116.

    Google Scholar 

  • Costain, D. W., Green, A. R., and Grahame-Smith, D. G., 1979, Enhanced 5-hydroxytryptamine-mediated behavioural responses in rats following repeated electroconvulsive shock: Relevance to the mechanism of the antidepressive effect of electroconvulsive therapy, Psychopharmacology 61: 167–170.

    PubMed  CAS  Google Scholar 

  • Costain, D. W., Cowen, P. J., Gelder, M. G., and Grahame-Smith, D. G., 1982, Electroconvulsive therapy and the brain: Evidence for increased dopamine-mediated responses, Lancet 2: 360–362.

    Google Scholar 

  • Costall, B., and Olley, J. E., 1971, Cholinergic and neuroleptic-induced catalepsy: Modification by lesions in the caudate putamen, Neuropharmacology 10: 297–306.

    PubMed  CAS  Google Scholar 

  • Cowen, P. J., 1985, Neuroendocrine responses as a probe into the mechanisms of action of ECT, Ann. NY Acad. Sci. 462: 163–171.

    Google Scholar 

  • Cowen, P. J., and Nutt, D. J., 1982, Repeated electroconvulsive shock enhances the anticonvulsant effect of benzodiazepines, Br. J. Pharmacol 75: 44 P.

    Google Scholar 

  • Cowen, P. J., Nutt, D. J., Baits, C. C., Green, A. R., and Heal, D. J., 1982, Repeated administration of subconvulsant doses of GABA antagonist drugs. II: Effect on mono-amine-mediated behaviour, Psychopharmacology 76: 88–91.

    PubMed  CAS  Google Scholar 

  • Creese, I., Kuczenski, R., and Segal, D., 1982, Lack of behavioural evidence for dopamine autoreceptor subsensitivity after acute electroconvulsive shock, Pharmacol Biochem. Behav. 17: 375–376.

    PubMed  CAS  Google Scholar 

  • Cupello, A., Fermillo, F., and Rozadini, G., 1981, Long lasting effects of electroconvulsive shock on the pattern of poly(A)-RNA synthesis in rabbit cerebral cortex, Neurochem. Res. 6: 175–182.

    PubMed  CAS  Google Scholar 

  • Dashieff, R. M., Savage, D. D., and Mcnamara, J. O., 1982, Seizures down-regulate muscarinic cholinergic receptors in hippocampal formation, Brain Res. 235: 327–334.

    Google Scholar 

  • Davies, C. L., and Nutt, D. J., 1983, Repeated electroconvulsive shock alters diazepam pharmacokinetics in rats, Br. J. Pharmacol. 78: 114 P.

    Google Scholar 

  • Davies, J. A., and Williams, J., 1978, The effect of baclofen on α-flupenthixol-induced catalepsy in the rat, Br. J. Pharmacol. 62: 303–305.

    PubMed  CAS  Google Scholar 

  • Deakin, J. F. W., Owen, F., Cross, A. J., and Dashwood, M. J., 1981, Studies on possible mechanisms of action of electroconvulsive therapy: Effects of repeated electrically- induced seizures on rat brain receptors for monoamines and other neurotransmitters, Psychopharmacology 73: 345–349.

    PubMed  CAS  Google Scholar 

  • de Montigny, C., 1984, Electroconvulsive shock treatments enhance responsiveness of forebrain neurons to serotonin, J. Pharmacol. Exp. Ther. 228: 230–236.

    PubMed  Google Scholar 

  • Dismukes, R. K., and Daly, J. W., 1974, Norepinephrine-sensitive systems generating adenosine 3′5′-monophosphate: Increased responses in cerebral cortical slices from reserpine-treated rats, Mol. Pharmacol. 10: 933–940.

    CAS  Google Scholar 

  • Durant, C. J., Duncan, N. A. M., Gannelin, C. R., Parsons, M. E., Blakemore, R., and Rasmussen, A., 1978, Impromidine (SK&F-92676) is a very potent and specific agonist for histamine H2 receptors, Nature 276: 403–405.

    PubMed  CAS  Google Scholar 

  • Emrich, H. M., and Höllt, V., 1984, Effect of ECT on endorphinergic systems: Clinical aspects, in: ECT: Basic Mechanisms ( B. Lerer, R. D. Weiner, and R. H. Belmaker, eds.), John Libbey Co., London, pp. 98–100.

    Google Scholar 

  • Essman, W. B., 1974, Neurochemistry of Cerebral Electroshock, John Wiley, New York.

    Google Scholar 

  • Evans, J. P. M., Grahame-Smith, D. G., Green, A. R., and Tordoff, A. F. C., 1976, Electroconvulsive shock increases the behavioural response of rats to brain 5-hydroxytryptamine accumulation and central nervous system stimulant drugs, Br. J. Pharmacol. 56: 193–199.

    PubMed  CAS  Google Scholar 

  • Faragalla, F. F., and Flach, F., 1970, Studies of mineral metabolism in mental depression. I. The effects of imipramine and electric convulsive therapy on calcium balance and kinetics J. Nero. Ment. Dis. 151: 120–129.

    CAS  Google Scholar 

  • Feighner, J. P., Low, L., King, L. J., and Ross, W. J., 1972, Brain serotonin and norepinephrine after convulsions and reserpine, J. Neurochem. 19: 905–907.

    PubMed  CAS  Google Scholar 

  • Ferendelli, J. A., and Kinscherf, D. A., 1977, Cyclic nucleotides in epileptic brain: Effects of pentylenetetrazol on regional cyclic AMP and cyclic GMP in vivo, Epilepsia 18: 525–531.

    Google Scholar 

  • File, S. E., 1980, The use of social interaction as a method of detecting anxiolytic activity of chlordiazepoxide-like drugs, J. Neurosci. Methods 2: 219–238.

    PubMed  CAS  Google Scholar 

  • File, S. E., and Green, A. R., 1984, Repeated electroconvulsive shock has no specific anxiolytic effect but reduces social interaction and exploration in rats, Neuropharmacology 23: 95–99.

    PubMed  CAS  Google Scholar 

  • Fink, M., 1974, Induced seizures and human behaviour, in: Psychobiology of Convulsive Therapy (M. Fink, S. Kety, J. McGaugh, and T. A. Williams, eds.), V. H. Winston 8c Sons, Washington, DC, pp. 1–17.

    Google Scholar 

  • Fink, M., 1979, Convulsive Therapy: Theory and Practice, Raven Press, New York.

    Google Scholar 

  • Fink, M., 1984, Theories of convulsive therapy: a neuroendocrine hypothesis, in: ECT Basic Mechanisms ( B. Lerer, R. D. Weiner, and R. H. Belmaker, eds.), John Libbey Co., London, pp. 115–123.

    Google Scholar 

  • Fink, M., and Ottosson, J.-O., 1980, A theory of convulsive therapy in endogenous depression: Significance of hypothalamic functions, Psychiatr. Res. 2: 49–61.

    CAS  Google Scholar 

  • Flach, F. F., 1964, Calcium metabolism in states of depression, Br. J. Psychiatry 110: 588–593.

    PubMed  CAS  Google Scholar 

  • Flach, F. F., Liang, E., and Stokes, P. E., 1960, Effects of electric convulsive treatments on nitrogen, calcium and phosphorous metabolism in psychiatric patients, J. Ment. Sci. 106: 638–647.

    PubMed  CAS  Google Scholar 

  • Freeman, C. P. L., Basson, J. V., and Crichton, A., 1978, Double-blind controlled trial of electroconvulsive therapy (ECT) and simulated ECT in depressive illness, Lancet 1: 738–740.

    PubMed  CAS  Google Scholar 

  • Frenk, H. J., Engel, J., Ackerman, R. F., Shavit, Y., and Liebeskind, J. C., 1979, Endogenous opiates may mediate post-ictal behavioural depression in amygdaloid-kindled rats, Brain Res. 167: 435–440.

    PubMed  CAS  Google Scholar 

  • Frith, C. D., Stevens, M., Johnstone, E. C., Deakin, J. F. W., Lawler, P., and Crow, T. J., 1983, Effects of ECT and depression on varous aspects of memory, Br. J. Psychiatry 142: 610–617.

    PubMed  CAS  Google Scholar 

  • Gandolfi, O., Dall’olio, R., and Montanaro, N., 1978, Early changes in rat brain 5-HT synthesis after a single electro-convulsive shock, Pharmacol. Res. Commun. 10: 75–79.

    PubMed  CAS  Google Scholar 

  • Garcia, A., Wang, C. H., Salama, A. I., and U’prichard, D.C., 1982, Regulation of rat cerebral cortex α2-receptor affinity states after electroconvulsive shock and antidepressant treatment, Soc. Neurosci. Abstr. 8: 525

    Google Scholar 

  • Gilbert, R. F. T., Emson, P. C., Hunt, S., Bennett, G. W., Marsden, C. A., Sandberg, B. E. B., and Steinbusch, H. W., 1981, The effect of monoamine neurotoxins on peptides in the rat spinal cord, Neuroscience 7: 69–87.

    Google Scholar 

  • Gillespie, D. D., Manier, D. H., and Sulser, F., 1979, ECT: Rapid subsensitivity of NA adenylate cyclase system in brain linked to down regulation of beta-receptors, Commun. Psychopharmacology 3: 191–195.

    CAS  Google Scholar 

  • Globus, M., Lerer, B., Hamburger, R., and Belmaker, R., 1981, Chronic electroconvulsive shock and chronic haloperidol are not additive in effects on dopamine receptors, Neuropharmacology 20: 1125–1128.

    PubMed  CAS  Google Scholar 

  • Goodwin, G. M., and Green, A. R., 1985, A behavioural and biochemical study in mice and rats of putative agonists and antagonists for 5-HT1 and 5-HT2 receptors, Br. J. Pharamacol. 84: 743–753.

    CAS  Google Scholar 

  • Goodwin, G. M., and Heal, D. J., 1985, DSP-4 lesioning abolishes the enhanced mono-amine-mediated behaviour following repeated electroconvulsive shock, Br. J. Pharmacol. 84: 538.

    Google Scholar 

  • Gour, K. N., and Chaudhry, H. M., 1957, Study of calcium metabolism in electric convulsive therapy (ECT) in certain mental diseases, J. Ment. Sci. 103: 275–285.

    PubMed  CAS  Google Scholar 

  • Grahame-Smith, D. G., Green, A. R., and Costain, D. W., 1978, Mechanism of the antidepressant action of electroconvulsive therapy, Lancet 1: 254–256.

    PubMed  CAS  Google Scholar 

  • Gray, J. A., Metz, A., Goodwin, G. M., and Green, A. R., 1986, The effects of the GABA-mimetic drugs Progabide and Baclefen on the biochemistry and function of 5-hydroxy-tryptamine and noradrenaline, Neuropharmacology 25: 711–716.

    PubMed  CAS  Google Scholar 

  • Green, A. R., 1978, Repeated exposure of rats to the convulsant agent flurothyl enhanced 5-hydroxytryptamine-and dopamine-mediated behavioural responses, Br. J. Pharmacol. 62: 325–331.

    PubMed  CAS  Google Scholar 

  • Green, A.R., 1986a, Changes in GABA biochemistry and seizure threshold, Ann. NY Acad. Sci. 462: 105–119

    PubMed  CAS  Google Scholar 

  • Green, A.R., 1986b, Electroconvulsive therapy: A GABAergic mechanism? in: GABA and Mood Disorders: Animal and Clinical Studies (K.G. Lloyd, G. Bartholini, and P.L. Morselli, eds.), Raven Press, New York, pp. 51–60

    Google Scholar 

  • Green, A. R., and Deakin, J. F. W., 1980, Brain noradrenaline depletion prevents ECS-induced enhancement of serotonin- and dopamine-mediated behaviour, Nature 285: 232–233.

    PubMed  CAS  Google Scholar 

  • Green, A. R., and Mountford, J. A., 1985, Diazepam administration to mice prevents some of the changes in monoamine-mediated behaviour produced by repeated electroconvulsive shock treatment, Psychopharmacology 86: 190–193.

    PubMed  CAS  Google Scholar 

  • Green, A. R., and Nutt, D. J., 1983, Antidepressants, in: Psychopharmacology, Vol. I ( D. G. Grahame-Smith and P.J. Cowen, eds.), Elsevier/Excerpta Medica, Amsterdam, pp. 1–37.

    Google Scholar 

  • Green„A. R., and Nutt, D. J., 1985, Antidepressants, in: Psychopharmacology, Vol. II ( D. G. Grahame-Smith and P. J. Cowen, eds.), Elsevier/Excerpta Medica, Amsterdam, pp. 1–33.

    Google Scholar 

  • Green, A. R., Tordoff, A. F. C., and Bloomfield, M. R., 1976, Elevation of brain GABA concentrations with amino-oxyacetic acid: Effect on the hyperactivity syndrome produced by increased 5-hydroxytryptamine synthesis in rats, J. Neural Transm. 39: 103–112.

    PubMed  CAS  Google Scholar 

  • Green, A. R., Heal, D. J., and Grahame-Smith, D. C., 1977, Further observations on the effect of repeated electroconvulsive shock on the behavioural responses of rats produced by increases in the functional activity of brain 5-hydroxytryptamine and dopamine, Psychopharmacology 52: 195–200.

    PubMed  CAS  Google Scholar 

  • Green, A. R., Peralta, E., Hong, J. S., Mao, C. D., Atterwill, C. K., and Costa, E., 1978, Alterations in GABA metabolism and met-enkephalin content in rat brain following repeated electroconvulsive shocks, J. Neurochem. 31: 607–611.

    PubMed  CAS  Google Scholar 

  • Green, A. R., Bloomfield, M. R., Atterwill, C. K., and Costain, D. W., 1979, Electroconvulsive shock recuces the cataleptogenic effects of both haloperidol and arecoline in rats, Neuropharmacology 18: 447–451.

    PubMed  CAS  Google Scholar 

  • Green, A. R., Costain, D. W., and Deakin, J. F. W., 1980, Enhanced 5-hydroxytryptamine-and dopamine-mediated behavioural response following convulsions. Ill: The effects of monoamine antagonists and synthesis inhibitors on the ability of electroconvulsive shock to enhance responses, Neuropharmacology 19: 907–914.

    PubMed  CAS  Google Scholar 

  • Green, A. R., Sant, K., Bowdler, J. M., and Cowen, P. J., 1982, Further evidence for a relationship between changes in GABA concentrations in rat brain and enhanced monoamine-mediated behaviours following repeated electroconvulsive shock, Neuropharmacology 21: 981–984.

    PubMed  CAS  Google Scholar 

  • Green, A.R., Heal, D.J., Johnson, P., Laurence, B.E., and Nimgaonkar, V.L., 1983a, Antidepressant treatments: effects in rodents on dose-response curves of 5-hydroxytryptamine-and dopamine-mediated behaviours and 5-HT2 receptor number in frontal cortex, Br. J. Pharmacol. 80: 377–385

    PubMed  CAS  Google Scholar 

  • Green, A.R., Johson, P., and Nimgaonkar, V.L., 1983b, Increased 5-HT receptor number in brain as a probable explanation for the enhanced 5-hydroxytryptamine-mediated behaviour following repeated electroconvulsive shock administration to rats, Br. J. Pharmacol. 80: 173–177

    PubMed  CAS  Google Scholar 

  • Green, A.R., Guy, A.P., and Gardner, C.R., 1984a, The behavioural effects of RU 24969, a suggested 5-HTI agonist in rodents and the effect on the behaviour of treatment with antidepressants, Neuropharmacology 23 655–661

    PubMed  CAS  Google Scholar 

  • Green, A.R., Nimgaonkar, V.L., and Goodwin, G.M., 1984b, β-Andrenoceptor agonists, ECT and other antidepressants: Effects on serotonin biochemistry and function, in: Proceedings of the 9th International Congress of Pharmacology, Vol. 3 (W.D.M. Paton, J.F. Mitchell, and R. Turner, eds.), Macmillan Press, Basingstoke, England, pp. 117–124

    Google Scholar 

  • Greenfield, S. A., 1984, Acetylcholinesterase may have novel functions in the brain, Trends Neurosci. 7: 364–368.

    CAS  Google Scholar 

  • Heal, D. J., 1984, Phenylephrine-induced activity in mice as a model of central α1-adrenoceptor function. Effects of acute and repeated administration of antidepressant drugs and electroconvulsive shock, Neuropharmacology 23: 1241–1251.

    PubMed  CAS  Google Scholar 

  • Heal, D. J., and Green, A. R., 1978, Repeated electroconvulsive shock increases the behavioural responses of rats to injection of both dopamine and dibutyryl cyclic AMP into the nucleus accumbens, Neuropharmacology 17: 1085–1087.

    PubMed  CAS  Google Scholar 

  • Heal, D. J., Phillips, A. G., and Green, A. R., 1978, Studies on the locomotor activity produced by injection of dibutyryl cyclic 3′5′-AMP into the nucleus accumbens of rats, Neuropharmacology 17: 265–270.

    PubMed  CAS  Google Scholar 

  • Heal, D. J., Akagi, H., Bowdler, J. M., and Green, A. R., 1981, Repeated electroconvulsive shock attenuates clonidine-induced hypoactivity in rodents, Eur. J. Pharmacol 75: 231–237.

    PubMed  CAS  Google Scholar 

  • Heal, D. J., Lister, S., Smith, S. L., Davies, C. L., Molyneux, S. G., and Green, A. R., 1983, The effects of acute and repeated administration of various antidepressants on clonidine hypoactivity in mice and rats, Neuropharmacology 22: 983–992.

    PubMed  CAS  Google Scholar 

  • Hendley, E. D., 1976, Electroconvulsive shock and norepinephrine uptake kinetics in rat brain, Psychopharmacol. Commun. 2: 17–25.

    PubMed  CAS  Google Scholar 

  • Holaday, J. W., and Belenky, G. L., 1980, Opiate-like effects of electroconvulsive shock in rats: A differential effect of naloxone on nociceptive measures, Life Sci. 27: 1929–1938.

    PubMed  CAS  Google Scholar 

  • Holaday, J. W., Belenky, G. L., Loh, H. H., and Meyerhoff, J. L., 1978, Evidence for endorphin release during electroconvulsive shock, Soc. Neurosci. Abstr. 4: 409.

    Google Scholar 

  • Hong, J. S., Gillin, J. C., Yang, H-Y. T., and Costa, E., 1979, Repeated electroconvulsive shocks and the brain content of endorphins, Brain Res. 177: 273–278.

    PubMed  CAS  Google Scholar 

  • Hong, J. S., Kanamatsu, T., Mcginty, J. F., Obie, J., Dyer, R. S., and Mitchell, C. L., 1985, Amygdaloid kindling increases enkephalin-like immunoreactivity but decreases dynorphin A-like immunoreactivity in rat hippocampus, Fed. Proc. 9: 2535–2539.

    Google Scholar 

  • Janowsky, A., Okada, F., Manier, D. H., Applegate, C. D., Sulser, F., and Steranka, L. R., 1982, Role of serotonergic input in the regulation of the β-adrenergic receptor-coupled adenylate cyclase system, Science (Washington) 218: 900–901.

    CAS  Google Scholar 

  • Johnson, R. W., Reisine, T., Spotnitz, S., Weich, N., Ursillo, R., and Yamamura, H. I., 1980, Effects of desipramine and yohimbine on alpha2- and beta-adrenoceptor sensitivity, Eur. J. Pharmacol 67: 123–127.

    PubMed  CAS  Google Scholar 

  • Jones, R. S. G., Mondadori, C., and Olpe, H-R., 1985, Neuronal sensitivity to substance P is increased after repeated treatment with tranylcypromine, carbamazepine or oxaprotaline but decreased after repeated electroconvulsive shock, Neuropharmacology 24: 627–633.

    PubMed  CAS  Google Scholar 

  • Kellar, K. J., 1984, ECS: effects on serotonergic and β-adrenergic receptor binding sites in brain, in: ECT: Basic Mechanisms ( B. Lerer, R. D. Weiner, and R. H. Belmaker, eds.), John Libbey & Co., London, pp. 46–56.

    Google Scholar 

  • Kellar, K.J., Cascio, C.S., Butler, J.A., and Kurtzke, R.W., 1981a, Differential effects of electroconvulsive shock and antidepressant drugs on serotonin-2-receptors in rat brain, Eur. J. Pharmacol. 69: 515–518

    PubMed  CAS  Google Scholar 

  • Kellar, K.J., Cascio, C.S., Bergstrom, D.A., Butler, J.A., and Iadarola, P., 1981b, Electroconvulsive shock and reserpine: Effects on β-adrenergic receptors in brain, J. Neurochem. 37: 830–836

    PubMed  CAS  Google Scholar 

  • Keller, H. H., Schaffner, R., and Haefely, W., 1976, Interactions of benzodiazepines with neuroleptics at central dopamine neurones, Naunyn-Schmiedeberg’s Arch. Pharmac. 294: 1–7.

    CAS  Google Scholar 

  • Kety, S. S., Javoy, F., Thierry, A. M., Julou, Z., and Glowinski, J., 1967, A sustained effect of electroconvulsive shock on the turnover of norepinephrine in the central nervous system of the rat, Proc. Natl. Acad. Sci. USA 58: 1249–1254.

    PubMed  CAS  Google Scholar 

  • Lambourn, J., and Gill, D., 1978, A controlled comparison of simulated and real ECT, Br. J. Psychiatry 133: 514–519

    PubMed  CAS  Google Scholar 

  • Lebrecht, U., and Nowak, J.Z., 1980a, Effect of single and repeated electroconvulsive shock on serotonergic system in rat brain, II: Behavioural studies, Neuropharmacology 19: 1049–1053

    PubMed  CAS  Google Scholar 

  • Lebrecht, U., and Nowak, J.Z., 1980a, Effect of single and repeated electroconvulsive shock on serotonergic system in rat brain, II: Behavioural studies, Neuropharmacology 19: 1055–1061

    PubMed  CAS  Google Scholar 

  • Lerer, B., 1985, Studies on the role of brain cholinergic systems in the therapeutic mechanisms and adverse effects of ECT and lithium, Biol. Psychiatry 20: 20–40.

    PubMed  CAS  Google Scholar 

  • Lerer, B., Jabotinsky-Rubin, K., Bannet, J., Ebstein, R. P., and Belmaker, R. H., 1982, Electroconvulsive shock prevents dopamine receptor supersensitivity, Eur. J. Pharmacol. 80: 131–134.

    PubMed  CAS  Google Scholar 

  • Lerer, B., Stanley, M., Demetriou, S., and Geershon, S., 1983, Effect of electroconvulsive shock on [3H]-QNB binding in rat cerebral cortex and hippocampus, J. Neurochem. 41: 1680–1683.

    PubMed  CAS  Google Scholar 

  • Lerer, B., Stanley, M., Mcintyre, I., and Altman, A., 1984, Electroconvulsive shock and brain muscarinic receptors: Relationship to anterograde amnesia, Life Sci. 35: 2659–2664.

    PubMed  CAS  Google Scholar 

  • Lewin, E., and Bleck, V., 1981, Electroshock seizures in mice: Effect on brain adenosine and its metabolites, Epilepsia 22: 577–581.

    PubMed  CAS  Google Scholar 

  • Lighton, K. G., Marsden, C. A., Bennett, G. W., Minchin, M. C. W., and Green, A. R., 1984, Decrease in levels of thyrotropin-releasing hormone (TRH) in the n. accumbens and lumbar spinal cord following repeated electroconvulsive shock, Neuropharmacology 23: 963–966.

    PubMed  CAS  Google Scholar 

  • Lighton, C., Bennett, G. W., and Marsden, C. A., 1985, Increase in levels and ex vivo release of thyrotrophin-releasing hormone (TRH) in specific regions of the CNS of the rat by chronic treatment with antidepressants, Neuropharmacology 24: 401–406.

    PubMed  CAS  Google Scholar 

  • Lloyd, K. G., and Pilc, A., 1984, Chronic antidepressants and GABA-B receptors, Poster; 9th International Congress on Pharmacology, London.

    Google Scholar 

  • Lloyd, K. G., Morselli, P. L., Depoortere, H., Fournier, V., Zivcovic, B., Scatton, B., Broekkamp, C., Worms, P., and Bartholini, G., 1983, The potential use of GABA agonists in psychiatric disorders, evidence from studies with progabide on animal models and clinical trials, Pharmacol. Biochem. Behav. 18: 957–966.

    PubMed  CAS  Google Scholar 

  • Lloyd, K. G., Thuret, F., and Pilc, A., 1985, Upregulation of gamma-aminobutyric acid (GABA)B binding sites in rat frontal cortex: A common action of repeated administration of different classes of antidepressants and electroshock, J. Pharmacol. Exp. Therap. 235: 191–199.

    CAS  Google Scholar 

  • Longoni, R., Mulas, A., Oderfeld, B., Pepeu, I. M., and Pepeu, G., 1976, Effect of single and repeated electroshock applications on brain acetylcholine levels and choline acetyl transferase activity in the rat, Neuropharmacology 15: 283–286.

    PubMed  CAS  Google Scholar 

  • Masserano, J. M., Takimoto, G. S., and Weiner, N., 1981, Electroconvulsive shock increases tyrosine hydroxylase activity in the brain and adrenal gland of the rat, Science (Washington) 214: 662–665.

    CAS  Google Scholar 

  • Mcgaugh, J. L., 1966, Time-dependent processes in memory storage, Science (Washington) 153: 1351–1358.

    CAS  Google Scholar 

  • Mcnamara, J. O., Peper, A. M., and Patrone, V., 1980, Repeated seizures induce long-term increase in hippocampal benzodiazepine receptors, Proc. Natl. Acad. Sci. USA 77: 3029–3032.

    PubMed  CAS  Google Scholar 

  • Mcwilliam, J. R., Meldrum, B. S., and Checkley, S. A., 1981, Enhanced growth hormone response to clonidine after repeated electroconvulsive shock in a primate species, Psychoneuroendocrinology 6: 77–79.

    PubMed  CAS  Google Scholar 

  • Mcwilliam, J. R., Meldrum, B. S., and Checkley, S. A., 1982, Changes in noradrenergic neuroendocrine responses following repeated seizures and the mechanisms of action of ECT, Psychopharmacology 77: 53–57.

    PubMed  CAS  Google Scholar 

  • Mellanby, J., Green, A. R., Impey, L., Oates, C., and Traynor, L., 1984, The effect of electroconvulsive shock on learning and memory in rats, Acta Neurol. Scand. 69 (99): 115–118.

    Google Scholar 

  • Metafora, S., Persico, M., Felsani, A., Ferraiuolo, R., and Guiditta, A., 1977, On the mechanism of the electroshock-induced inhibition of protein synthesis in rabbit cerebral cortex, J. Neurochem. 28: 1335–1346.

    PubMed  CAS  Google Scholar 

  • Metz, A., Goodwin, G. M., and Green, A. R., 1985, The administration of baclofen to mice increases 5-HT2-mediated head-twitch behaviour and 5-HT2 receptor number in frontal cortex, Neuropharmacology 24: 257–260.

    Google Scholar 

  • Minchin, M. C. W., and Nutt, D. J., 1983, Studies on [3H]-diazepam and [3H]-ethyl-β-carboline carboxylate binding to rat brain in vivo. I: Regional variations in displacement, J. Neurochem. 41: 1507–1512.

    PubMed  CAS  Google Scholar 

  • Minchin, M. C. W., and Nutt, D. J., 1984, The effect of repeated electroconvulsive shock on the function of THIP, a GABA agonist, Pharmacol. Biochem. Behav. 21: 491–493.

    PubMed  CAS  Google Scholar 

  • Minchin, M. C. W., Williams, J., Bowdler, J. M., and Green, A. R., 1983, The effect of electroconvulsive shock on the uptake and release of noradrenaline and 5-hydroxy- tryptamine in rat brain slices, J. Neurochem, 40: 765–768.

    PubMed  CAS  Google Scholar 

  • Modigh, K., 1975, Electroconvulsive shock and postsynaptic catecholamine effects: Increased psychomotor stimulant action of apomorphine and clonidine in reserpine pretreated mice by repeated ECS, J. Neural Transm. 36: 19–32.

    PubMed  CAS  Google Scholar 

  • Modigh, K., 1976, Long-term effects of electroconvulsive shock therapy on synthesis, turnover, and uptake of brain monoamines, Psychopharmacology 49: 179–185

    PubMed  CAS  Google Scholar 

  • Modigh, K., 1979, Long lasting effects of ECT on monoaminergic mechanisms, in: Neuropsychopharmacology ( B. Saletu, P. Berner, and L. Hollister, eds.), Pergamon Press, Oxford.

    Google Scholar 

  • Musacchio, J. M., Julou, I., Kety, S. S., and Glowinski, J., 1969, Increase in rat brain tyrosine hydroxylase activity produced by electroconvulsive shock, Proc. Natl. Acad. Sci. USA 63: 1117–1119.

    PubMed  CAS  Google Scholar 

  • Myslobodsy, M. S., and Mintz, M., 1981, Postictal behavioral arrest in the rat: “Catalepsy” or “catatonia”? Life Sci. 28: 2287–2293.

    Google Scholar 

  • Myslobodsky, M., Kofman, O., and Mintz, M., 1981, Convulsant-specific architecture of the postictal behaviour syndrome in the rat, Epilepsia 22: 559–568.

    PubMed  CAS  Google Scholar 

  • Newman, M., Zohar, J., Kalian, M., and Belmaker, R. H., 1984, Effects of ECS on adenosine receptor systems in the brain, in: ECT: Basic Mechanisms ( B. Lerer, R. D. Weiner, and R. H. Belmaker, eds.), John Libbey Co., London, pp. 57–61.

    Google Scholar 

  • Nimgaonkar, V. L., Goodwin, G. M., Davies, C. L., and Green, A. R., 1985, Down-regulation of β-adrenoceptors in rat cortex by repeated administration of desipramine, electroconvulsive shock and clenbuterol requires 5-HT neurones but not 5-HT, Neuropharmacology 24: 279–283.

    PubMed  CAS  Google Scholar 

  • Nimgaonkar, V. L., Heal, D. J., Davies, C. L., and Green, A. R., 1986, Studies on rat brain catecholamine synthesis and B-adrenoceptor number following administration of electroconvulsive shock, desipramine and clenbuterol, J. Neurol. Transm. 65: 245–259.

    CAS  Google Scholar 

  • Nutt, D. J., and Minchin, M. C. W., 1983, Studies of [3H]-diazepam and [3H]-ethyl-β-carboline carboxylate binding to rate brain in vivo. II: Effects of electroconvulsive shock, J. Neurochem. 41: 1514–1517.

    Google Scholar 

  • Nutt, D.J., Green, A.R., and Grahame-Smith, D.G., 1980a, Enhanced 5-hydroxytryptamine- and dopamine-mediated behavioural responses following convulsions. 1: The effects of single and repeated bicuculline-induced seizures, Neuropharmacology 19: 897–900

    PubMed  CAS  Google Scholar 

  • Nutt, D.J., Cowen, P.J., and Green, A.R., 1980b, On the measurement of rats of the convulsant effect of drugs and the changes which follow electroconvulsive shock, Neuropharmacology 19: 1018–1023

    Google Scholar 

  • Nutt, D. J., Cowen, P. J., and Green, A. R., 1981, Studies on the post-ictal rise in seizure threshold, Eur. J. Pharmacol. 71: 287–295.

    PubMed  CAS  Google Scholar 

  • Nutt, D. J., Smith, S. L., and Heal, D. J., 1982, Hypophysectomy does not prevent the enhanced monoamine-mediated behavioural responses following repeated electroconvulsive shocks, Neuropharmacology 21: 881–884.

    PubMed  CAS  Google Scholar 

  • Olney, J. W., De Gubaneff, T., and Labruyere, J., 1983, Seizure-related brain damage induced by cholinergic agents, Nature 310: 520–522.

    Google Scholar 

  • Pandey, G. N., Heinze, W. J., Brown, B. D., and Davis, J. M., 1979, Electroconvulsive shock treatment decreases beta-adrenergic receptor sensitivity in rat brain, Nature 280: 234–235.

    PubMed  CAS  Google Scholar 

  • Paul, S. M., and Skolnick, P., 1978, Rapid changes in brain benzodiazepine receptors after experimental seizures, Science 202: 892–894.

    PubMed  CAS  Google Scholar 

  • Pedigo, N. W., Yamamura, H. I., and Nelson, D. L., 1981, Discrimination of multiple [3H]-5-hydroxytryptamine binding sites by the neuroleptic spiperone in rat brain, J. Neurochem. 36: 220–226.

    PubMed  CAS  Google Scholar 

  • Peroutka, S. J., and Snyder, S. H., 1979, Multiple serotonin receptors: Differential binding of [3H]-hydroxytryptamine, [3H]-lysergic acid diethylamide and [3H]-spiroperidol, Mol. Pharmacol. 16: 687–699.

    PubMed  CAS  Google Scholar 

  • Peroutka, S. J., and Snyder, S. H., 1980, Long term antidepressant treatment decreases spiroperidol-labelled serotonin receptor binding, Science 210: 88.

    PubMed  CAS  Google Scholar 

  • Perumal, A.S., and Barkai, A.I., 1982, β-Adrenergic receptor binding in different regions of rat brain after various intensities of electroshock: Relationship to postictal EEG, J. Neurosci. Res. 7: 289–296

    PubMed  CAS  Google Scholar 

  • Pilc, A., and Vetulani, J., 1982, Depression by chronic electroconvulsive treatment of clonidine hypothermia and [3H]-clonidine binding to rat cortical membranes, Eur. J. Pharmacol. 80: 109–113.

    PubMed  CAS  Google Scholar 

  • Pilc, A., Rogoz, Z., and Byrska, B., 1980, Some central effects of impromidine, a potent agonist of histamine H2 receptor, Neuropharmacology 19: 947–950.

    PubMed  CAS  Google Scholar 

  • Royal College of Psychiatrists, 1977, The Royal College of Psychiatrists memorandum on the use of electroconvulsive therapy, Br. J. Psychiatry 131: 261–272.

    Google Scholar 

  • Sackheim, H. A., Decina, P., Prohovnik, I., Malitz, S., and Resor, S. K., 1983, Anticonvulsant and antidepressant properties of electroconvulsive therapy: A proposed mechanism of action, Biol. Psychiatry 18: 1301–1310.

    Google Scholar 

  • Sattin, A., 1971, Increase in the content of adenosine 3′5′-monophosphate in mouse forebrain during seizures and prevention of the increase by methylxanthines, J. Neurochem. 18: 1087–1096

    PubMed  CAS  Google Scholar 

  • Sattin, A., 1981, Adenosine as a mediator of antidepressant treatment, in: Chemisms of the Brain ( R. Rodnight, H. S. Bachelard, and W. L. Stahl, eds.), Churchill-Livingstone, Edinburgh, pp. 265–275.

    Google Scholar 

  • Schlicker, E., Classen, K., and Gothert, M., 1984, GABA receptor-mediated inhibition of serotonin release in the rat brain, Naunyn-Schiedeberg’s Arch. Pharmac. 326: 99–105.

    CAS  Google Scholar 

  • Serra, G., Argiolas, A., Fadda, F., Melis, M. R., and Gessa, G. L., 1981, Repeated electroconvulsive shock prevents the sedative effect of small doses of apomorphine, Psychopharmacology 73: 194–196.

    PubMed  CAS  Google Scholar 

  • Shields, P. J., 1972, Effects of electroconvulsive shock on the metabolism of 5-HT in the rat brain, J. Pharm. Pharmacol. 23: 919–920.

    Google Scholar 

  • Slade, A. P., and Checkley, S. A., 1980, A neuroendocrine study of the mechanism of action of ECT, Br. J. Psychiatry 137: 217–221.

    PubMed  CAS  Google Scholar 

  • Stanford, S. C., and Nutt, D. J., 1982, Comparison of the effects of repeated electroconvulsive shock on α2-adrenoceptors different regions of rat brain, Neuroscience 7: 1753–1757.

    PubMed  CAS  Google Scholar 

  • Stanford, C., Nutt, D. J., and Cowen, P. J., 1983, Comparison of the effects of chronic desmethylimipramine administration on α2- and β-adrenoceptors in different regions of rat brain, Neuroscience 8: 161–164.

    PubMed  CAS  Google Scholar 

  • Stanley, M., and Lerer, B., 1985, Electroconvulsive shock and cholinergic function: Role of striatal muscarinic receptors, Convulsive Ther. 1: 158–166.

    Google Scholar 

  • Steiner, J. A., and Grahame-Smith, D. G., 1980, The effect of repeated electroconvulsive shock on corticosterone responses to centrally acting pharmacological stimuli in the male rate, Psychopharmacology 71: 205–212.

    PubMed  CAS  Google Scholar 

  • Steiner, J. A., Evans, G., and Grahame-Smith, D. G., 1982, The effect of repeated electroconvulsive shocks on growth hormone secretion and growth hormone responses to clonidine in the intact rat, Psychopharmacology 76: 98–100.

    PubMed  CAS  Google Scholar 

  • Sugrue, M. F., 1981, Effects of acutely and chronically administered antidepressants on the clonidine-induced decrease in rat brain 3-methoxy-4-hydroxyphenylethyleneglycol sulphate content, Life Sci. 28: 377–384.

    PubMed  CAS  Google Scholar 

  • Sugrue, M. F., 1982, A study of the sensitivity of rat brain α2-adrenoceptors during chronic antidepressant treatments, Naunyn-Schmiedeberg’s Arch. Pharmacol. 320: 90–96.

    PubMed  CAS  Google Scholar 

  • Sulser, F., and Mobley, P. L., 1981, Regulation of central noradrenergic receptor functions: New vistas on the mode of action of antidepressant treatments, in: Neuroregulators: Basic and Clinical Aspects ( E. Usdin, J. M. Davis, and W. E. Bunney, eds.), John Wiley & Sons, Chichester, pp. 55–83.

    Google Scholar 

  • Tacke, U., Paananen, A., and Tuomisto, J., 1984, Seizure thresholds and their postictal changes in audiogenic seizure (AGS)-susceptible rats, Eur. J. Pharmacol. 104: 85–92.

    PubMed  CAS  Google Scholar 

  • Tortella, F. C., Cowan, A., Belenky, G. L., and Holaday, J. W., 1981, Opiate-like electroencephalographic and behavioural effects of electroconvulsive shock in rats, Eur. J. Pharmacol. 76: 121–128.

    PubMed  CAS  Google Scholar 

  • Tortella, F. C., Cowan, A., and Adler, M. W., 1984, Studies on the excitatory and inhiitory influence of intracerebroventricularly injected opioids on seizure thresholds in rats, Neuropharmacology 23: 749–754.

    PubMed  CAS  Google Scholar 

  • Turski, W. A., Czuczwar, S. J., Kleinvok, Z., and Turski, L., 1983, Cholinomimetics produce seizures and brain damage in rats, Experientia 39: 1408.

    PubMed  CAS  Google Scholar 

  • U’prichard, D., Bechtel, W., Roust, B., and Snyder, S. H., 1979, Multiple apparent alpha noradrenergic receptor binding sites in rat brain: Effect of 6-hydroxydopamine, Mol. Pharmacol. 16: 47–60.

    PubMed  Google Scholar 

  • Vetulani, J., 1984, Changes in responsiveness of central aminergic structures after chronic ECS, in: ECT: Basic Mechanisms ( B. Lerer, R. D. Weiner, and R. H. Belmaker, eds.), John Libbey Co., London, pp. 33–45.

    Google Scholar 

  • Vetulani, J., and Pilc, A., 1982, Postdecapitation convulsions in the rat measured with an Anime motility meter: Relation to central α-adrenoceptors, Eur. J. Pharmacol. 85: 269–275.

    PubMed  CAS  Google Scholar 

  • Vetulani, J., and Sulser, F., 1975, Action of various antidepressant treatments reduced reactivity of noradrenergic cyclic AMP generating system in limbic forebrain, Nature 257: 495–496.

    PubMed  CAS  Google Scholar 

  • Vetulani, J., Stawarz, R. J., Dingell, J. V., and Sulser, F., 1976, A possible common mechanism of action of antidepressant treatments. Reduction in the sensitivity of noradrenergic cyclic AMP generating system in the rat limbic forebrain, Naunyn-Schmiedeberg’s Arch. Pharmacol. 293: 109–144.

    PubMed  CAS  Google Scholar 

  • Vetulani, J., Antkiewicz-Michaluk, L., Golembiowska-Nikitin, K., Michaluk, J., Pilc, A., and Rokosz, A., 1980, The effect of multiple imipramine administration on monoaminergic systems of the rat brain, Pol. J. Pharmacol. 32: 523–530.

    CAS  Google Scholar 

  • Vetulani, J., Lebrecht, U., and Pilc, A., 1981, Enhancement of responsiveness of the central serotonergic system and serotonin-2-receptor density in rat frontal cortex by electroconvulsive treatments, Eur. J. Pharmacol. 76: 81–85.

    PubMed  CAS  Google Scholar 

  • Vetulani, J., Antkiewicz-Michaluk, L., Rokosz-Pelc, A., and Pilc, A., 1983, Chronic electroconvulsive treatment enhances density of [3H]-prazosin binding sites in the central nervous system of the rat, Brain Res. 275: 392–395.

    PubMed  CAS  Google Scholar 

  • Wasterlain, C. G., and Csiszor, E., 1980, Cyclic nucleotide metabolism in mouse brain during seizures induced by bicuculline or dibutyryl cyclic guanosine monophosphate, Exp. Neurol. 70: 260–268.

    PubMed  CAS  Google Scholar 

  • Weeks, D., Freeman, C. P. L., and Kendell, R. E., 1980, ECT III: Enduring cognitive defects, Br. J. Psychiatry 137: 26–37.

    PubMed  CAS  Google Scholar 

  • Weilosz, M., 1981, Increased sensitivity to dopaminergic agonists after repeated electroconvulsive shock in rats, Neuropharmacology 20: 941–945.

    Google Scholar 

  • White, D. K., and Barrett, R. J., 1981, The effects of electroconvulsive shock on the discriminative stimulus properties of d-amphetamine and apomorphine: Evidence for dopamine receptor alteration subsequent to ECS, Psychopharmacology 73: 211–214.

    PubMed  CAS  Google Scholar 

  • Worms, P., and Lloyd, K. G., 1978, Influence of GABA-agonists and antagonists on neuroleptic-induced catalepsy in rats, Life Sci. 23: 475–478.

    PubMed  CAS  Google Scholar 

  • Yoshikawa, K., Hong, J. S., and Sabol, S. L. 1985, Electroconvulsive shock increases pre-proenkephalin messenger RNA abundance in rat hypothalamus, Proc. Natl. Acad. Sci. U.S.A. 82: 589–593.

    PubMed  CAS  Google Scholar 

  • Zivkovic, B., Scatton, B., Dedek, J., and Bartholini, G., 1982, GABA influence on noradrenergic and serotonergic transmissions: Implications in mood regulation, in: New Vistas in Depression, Advances in Bioscience, Vol. 40, Pergamon Press, Oxford, pp. 195–201.

    Google Scholar 

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Authors and Affiliations

  1. MRC Clinical Pharmacology Unit, Radcliffe Infirmary, Oxford, OX2 6HE, England

    A. Richard Green

  2. Astra Neuroscience Research Unit, 1 Wakefield Street, London, WC1N 1PJ, England

    A. Richard Green

  3. Department of Psychiatry, Research Unit, Littlemore Hospital, Oxford, OX4 4NX, England

    David J. Nutt

  4. National Institute for Alcohol Abuse and Alcoholism, Bethesda, Maryland, 20205, USA

    David J. Nutt

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  1. Department of Psychology, University of Cambridge, USA

    Leslie L. Iversen  & Susan D. Iversen  & 

  2. Departments of Neuroscience, Pharmacology, and Psychiatry, The Johns Hopkins University School of Medicine, USA

    Solomon H. Snyder

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Green, A.R., Nutt, D.J. (1987). Psychopharmacology of Repeated Seizures: Possible Relevance to the Mechanism of Action of Electroconvulsive Therapy. In: Iversen, L.L., Iversen, S.D., Snyder, S.H. (eds) Handbook of Psychopharmacology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1819-4_6

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