Advertisement

Ultrasound pp 185-193 | Cite as

Immunological and Genetic Effects

  • A. R. Williams

Abstract

The obvious importance of the immunological system in the protection from infection and the role of DNA as the store of genetic information for future generations means that both of these systems have been intensively investigated as potential “targets” for ultrasound interactions. In common with many other areas of biological investigation the majority of the published reports are concerned with the in vitro exposure of isolated cells or even purified macromolecules. This is a reflection of the fact that it is often difficult to obtain a precise measurement of a given vital function in vivo (partly because of the difficulty of access without perturbing the function you are trying to measure and partly because of the inherent homeostatic mechanisms which operate to prevent any change). Consequently, in vitro exposure systems are favoured because they enable more sophisticated and/or quantifiable measurements to be performed.

Keywords

Chromosome Aberration Sister Chromatid Exchange Popliteal Lymph Node Diagnostic Ultrasound Ultrasonic Radiation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Anderson, D. W. and Barrett, J. T., 1979, Ultrasound: a new immunosuppressant. Clin. Immunol. Immunopathol.. 14: 18.PubMedCrossRefGoogle Scholar
  2. Anderson, D. W. and Barrett, J. T., 1981, Depression of phagocytosis by ultrasound, Ultrasound Med. Biol.. 7: 267.Google Scholar
  3. Child, S. Z., Hare, J. D., Carstensen, E. L., Vives, B., Davis, J., Adler, A. and Davis, H.T., 1981. Test for the effects of diagnostic levels of ultrasound on the immune response of mice, Clin. Immunol. Immunopathol.. 18: 299.CrossRefGoogle Scholar
  4. Combes, R. D., 1975, Absence of mutation following ultrasonic treatment of Bacillus subtilis cells and transforming deoxyribonucleic acid, Brit. J. Radiol.. 48: 306.PubMedCrossRefGoogle Scholar
  5. Crowell, J. A., Kusserow, B. K. and Nyborg, W. L., 1977, Functional changes in white cells after microsonation, Ultrasound Med. Biol.. 3: 185.PubMedCrossRefGoogle Scholar
  6. Dyer, H. J., 1972, Structural effects of ultrasound on the cell, In “Interactions of Ultrasound and Biological Tissues”, Eds. J. M. Reid and M. R. Sikov, DHEW Publication 73–8008, (FDA): 73.Google Scholar
  7. Ehlinger, C. A., Katayama, P. K., Roester, M. R. and Mattingly, R. F., 1981, Diagnostic ultrasound increases sister chromatid exchange; preliminary report, Wise. Med. J.. 80: 21.Google Scholar
  8. Ford, W. L., Burr, W. and Simonsen, M., 1970, A lymph node weight assay for the grafversus-host activity of rat lymphoid cells, Transplantation. 10: 258.PubMedCrossRefGoogle Scholar
  9. Fung, H., Cheung, K., Lyons, E.A. and Kay, N.E., 1978, The effect of low dose ultrasound on human peripheral lymphocyte function in vitro. In “Ultrasound in Medicine”, Eds. D. N. White and E. A. Lyons, Plenum Press, N.Y., 4: 583.Google Scholar
  10. Galperin-Lemaitre, H., Kirsch-Volders, M. and Levi, S., 1975, Ultrasound and mammalian DNA, Lancet. 2: 662.PubMedCrossRefGoogle Scholar
  11. Gebhart, E., 1981, Sister chromatid exchange (SCE) and structural chromosome aberration in mutagenicity testing (review article), Human Genetics. 58: 235.PubMedCrossRefGoogle Scholar
  12. Goss, S. A., 1984, Sister chromatid exchange and ultrasound, J. Ultrasound Med.. 3: 463.PubMedGoogle Scholar
  13. Haupt, M., Martin, N., Simpson, J. L., Iqbal, M., Elias, S., Dyere, A. and Sabbagha, R. E., 1981, Ultrasonic induction of sister chromatid exchanges in human lymphocytes, Human Genetics, 39: 221.Google Scholar
  14. Kunze-Muhl, E. and Golob, E., 1972, Chromosomenanalysen nach Ultraschalleinwirkung, Humangenetik, 14; 237.PubMedCrossRefGoogle Scholar
  15. Liebeskind, D., Bases, R., Elequin, F., Neubort, S., Leifer, R., GOLDBERG, R. and Koenigsberg, M., 1979a Diagnostic ultrasound: effects on the DNA and growth patterns of animal cells, Radiology, 131: 177.PubMedGoogle Scholar
  16. Liebeskind, D., Bases, R., Mendez, F., Elequin, F. and Koenigsberg, M., 1979b, Sister chromatid exchanges in lymphocytes after exposure to diagnostic ultrasound, Science. 205: 1273.PubMedCrossRefGoogle Scholar
  17. Macintosh, I. J. C, Brown, R. C. and Coakley, W. T., 1975, Ultrasound and In vitro chromosome aberrations, Brit. J. Radiol.. 48: 230.CrossRefGoogle Scholar
  18. Macintosh, I. J. C. and Davey, D. A., 1970, Chromosome aberrations induced by an ultrasonic foetal pulse detector, Brit. Med. J.. 4; 92.PubMedCrossRefGoogle Scholar
  19. Macintosh, I. J. C. and Davey, D. A., 1972, Relationship between intensity of ultrasound and induction of chromosome aberrations. Brit. J. Radiol.. 45: 320.PubMedCrossRefGoogle Scholar
  20. Saad, A.H. and Williams, A.R., 1982, Effects on therapeutic ultrasound on clearance rate of blood borne colloidal particles in vivo. Brit. J. Cancer. 45: 202.Google Scholar
  21. Spencer, J. L., 1952, Effects of intense ultrasonic vibrations on Pisum. II. Effects on growth and their inheritance, Growth. 16: 255.PubMedGoogle Scholar
  22. Thacker, J., 1973, The possibility of genetic hazard from ultrasonic radiation, Curr. Topics. Rad. RES. P.. 8: 235.Google Scholar
  23. Thacker, J., 1974, An assessment of ultrasonic radiation hazard using yeast genetic systems, Brit. J. Radiol.. 47: 130.PubMedCrossRefGoogle Scholar
  24. Wang, S. Y., 1977, Ultrasonic radiation of nucleic acid components, Svmp. Biol. Effects and Characterization of Ultrasound Sources. HEW Publication 78-8048: 196.Google Scholar
  25. Wells, P. N. T., 1977, “Biomedical Ultrasonics”, Academic Press, London, N.Y.Google Scholar
  26. Williams, A. R., 1983, “Ultrasound: biological effects and potential hazards”, Academic Press, London, N.Y.Google Scholar
  27. Williams, A. R., Sykes, S. M., and O’Brien, W. D. J., 1976, Ultrasonic exposure modifies platelet morphology and function in vitro. Ultrasound Med. BioL 2: 311.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • A. R. Williams
    • 1
  1. 1.Department of Medical BiophysicsUniversity of Manchester Medical SchoolManchesterEngland

Personalised recommendations