Contact Angle Analysis of Biomedical Polymers: From Air to Water to Electrolytes

  • J. D. Andrade
Part of the Polymer Science and Technology book series (POLS, volume 34)


The surface characterization of biomedical materials prior to the early 1960’s consisted primarily of relatively qualitative observations as to whether surfaces were hydrophobic or hydrophilic (1). Contact angle techniques were well-known and were widely applied in industry, and general correlations had evolved between blood interactions in glass as opposed to siliconized glass tubes. Vroman was just beginning his studies on protein interactions with surfaces (2). There was considerable interest during this time period on the interaction of cells in culture with solid substrates, and there was some attempt to correlate and quantitate that interaction through contact angle measurements (3).


Contact Angle Polymer Surface Contact Angle Measurement Contact Angle Hysteresis Advance Contact Angle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    R. E. Baier, “Surface Properties Influencing Biological Adhesion,”in Adhesion in Biological Systems (R. S. Manley, ed.), Academic Press, 1970, pp. 15–48.Google Scholar
  2. 2.
    L. Vroman, “Effect of Adsorbed Proteins on the Wettability of Hydrophilic and Hydrophobic Solids,”Nature 196 (1962) 476CrossRefADSGoogle Scholar
  3. 3.
    P. van der Valk, A. W. J. van Pelt, H. J. Busscher, H. P. de Jong, Ch. R. H. Wildevuur, and J. Arends, “Interaction of Fibroblasts and Polymer Surfaces: Relationship between Surface Free Energy and Fibroblast Spreading.”J. Biomed. Mat. Res. 17 (1983) 807–817.CrossRefGoogle Scholar
  4. 4.
    A. W. Adamson, Physical Chemistry of Surfaces, 4th ed., Wiley, New York (1983).Google Scholar
  5. 5.
    W. A. Zisman, “Relation of the Equilibrium Contact Angle to Liquid and Solid Constitution,”in Contact Angle, Wettability, and Adhesion (F. M. Fowkes, ed), Adv. Chem. Ser. 43, 1–51 (1964).CrossRefGoogle Scholar
  6. 6.
    R. E. Baier, “Role of Surface Energy in Thrombogenesis,”Bull. New York Acad. Med. 48 (1972) 257–272.Google Scholar
  7. 7.
    F. M. Fowkes, “Attractive Forces at Interfaces,”Chem. and Physics of Interfaces (S. Ross, ed.), Amer. Chem. Soc. (1965) 1–12.Google Scholar
  8. 8.
    R. J. Good and E. Elbing, “Theory for Estimation of Interfacial Energies,”in Chem. and Physics of Interfaces 2 (S. Ross, ed.), Amer. Chem. Soc., (1968) 71–96.Google Scholar
  9. 9.
    R. J. Good, “Intermolecular Forces,”in Treatise on Adhesion and Adhesives 1 (R. L. Patrick, ed.) Dekker, 1966 pp. 9–68.Google Scholar
  10. 10.
    D. J. Lyman, W. M. Muir, and I. J. Lee, “The Effect of Chemical Structure and Surface Properties of Polymers on the Coagulation of Blood. I. Surface Free Energy Effects,”Trans. Am. Soc. Artif. Int. Organs 11 (1965) 301–306.Google Scholar
  11. 11.
    R. E. Baier, V. L. Gott, and A. Feruse, “Surface Chemical Evaluation....”, Trans. Am. Soc. Art. Int. Org. 16 (1979) 50–57.Google Scholar
  12. 12.
    D. H. Kaelble, Physical Chemistry of Adhesion, Wiley, New York (1971).Google Scholar
  13. 13.
    E. Nyilas, W. A. Morton, D. M. Lederman, T. H. Chin, R. D. Cumming, “Interdependence of Hemodynamic and Surface Parameters in Thrombosis,”Trans. Amer. Soc. Artif. Internal Organs 21 (1975) 55–63.Google Scholar
  14. 14.
    J. D. Andrade, “Interfacial Phenomena and Bimaterials,”Med. Inst. 7 (1973) 110–120.Google Scholar
  15. 15.
    o. Wichterle and D. Lim, “Hydrophilic Gels for Biological Use,”Nature 185 (1960) 117–119.CrossRefADSGoogle Scholar
  16. 16.
    L. Vroman, Blood, Natural History Press, 1966.Google Scholar
  17. 17.
    J. D. Andrade, H. B. Lee, M. S. Jhon, S. W. Kim, J. B. Hibbs, “Water as a Biomaterial,”Trans. Amer. Soc. Artif. Internal Organs 19 (1973) 1–6.Google Scholar
  18. 18.
    F. J. Holly and M. F. Refojo,“Wettability of Hydrogels”, J. Biomed. Materials Res. 9 (1975) 315–326.CrossRefGoogle Scholar
  19. 19.
    J. D. Andrade, D. E. Gregonis, L. M. Smith, “Polymer Surface Dynamics,”in Surface and Interfacial Aspects of Biomedical Polymers 1 (J. D. Andrade, ed.), Plenum Press, 1985, pp. 15–41.Google Scholar
  20. 20.
    R. N. King, S. M. Ma, D. E. Gregonis, L. Brostrom, “Interfacial Tensions at Acrylic Hydrogel-Water Interfaces,”J. Colloid Interface Sci. 103 (1985) 62–75.CrossRefGoogle Scholar
  21. 21.
    W.C. Hamilton, J. Colloid Interface Sci. 40 (1972) 219; 47 (1974) 672.CrossRefGoogle Scholar
  22. 22.
    J. D. Andrade, S. M. Ma, R. N. King, D. E. Gregonis, “Contact Angles at the Solid-Water Interface,”J. Coll. Interface Sci. 72 (1979) 488–496.CrossRefGoogle Scholar
  23. 23.
    J. D. Andrade, R. N. King, D. E. Gregonis, and D. L. Coleman, “Surface Characterization of Poly(hydroxyethyl) Methacrylate and Related Polymers I. Contact Angle Methods in Water,”J. Polymer Sci., Polymer Symp. 66 (1979) 383.Google Scholar
  24. 24.
    J. D. Andrade, L. M. Smith, D. E. Gregonis, “Contact Angle and Interface Energetics,”in Surface and Interfacial Aspects of Biomedical Polymers 1 (J. D. Andrade, ed.), Plenum Press, 1985, pp 249–291.Google Scholar
  25. 25.
    Polymer Surface Dynamics Symposium at the Rocky Mountain Regional American Chemical Soc. Meeting, Denver, CO, June 9–11, 1986.Google Scholar
  26. 26.
    F. M. Fowkes, “Interface Acid-Base/Charge-Transfer Properties,”in Surface and Interfacial Aspects of Biomedical Polymers 1 (J. D. Andrade, ed.), Plenum Press, 1985, pp 337–372.Google Scholar
  27. 27.
    C. O. Timmons and W. A. Zisman, “Effect of Liquid Structure on Contact Angle Hysteresis,”J. Colloid Interface Sci. 22 (1966) 165–171.CrossRefGoogle Scholar
  28. 28.
    A. H. Hogt, D. E. Gregonis, J. D. Andrade, S.W. Kim, J. DanKert, J. Feijen, “Wettability of a Series of Methacrylate Copolymers,”J. Colloid Interface Sci. (1985) in press.Google Scholar
  29. 29.
    D. L. Coleman, “Blood -Materials Interactions--A Multiparameter Approach,”Ph.D. Thesis, University of Utah, 1980.Google Scholar
  30. 30.
    S. Nagaoka, Y. Mori, H. Takiuchi, K. Yokota, H. Tanzawa, and S. Nishiumi, “Interaction Between Blood Components and Hydrogels with Poly(Oxyethylene) Chains,”Polymers as Biomaterials (S. W. Shalaby, A. S. Hoffman, B. D. Ratner and T. A. Horbett, ed.) Plenum Publishing Corp. 1984, pp. 361–374.CrossRefGoogle Scholar
  31. 31.
    R. N. King, “Surface Characterization of Synthetic Polymers for Biomedical Applications,”Ph.D. Thesis, University of Utah, 1980.Google Scholar
  32. 32.
    W. Y. Chen and J. D. Andrade, “Surface Characteristics of Polysulfoalkyl Methacrylates,”J. Colloid Interface Sci. (1985) in press.Google Scholar
  33. 33.
    R. A. VanWagenen, D. L. Coleman, R. N. King, P. Triolo, L. Brostrom, L. M. Smith, J. D. Andrade, “Streaming Potentials of Polymer Thin Films,”J. Colloid Interface Sci. 84 (1981) 155–165.CrossRefGoogle Scholar
  34. 34.
    J. Lyklema, “Interfacial Electrochemistry of Surfaces with Biomedical Relevance,”in Surface and Interfacial Aspects of Biomedical Polymers 1 (J. D. Andrade, ed.), Plenum Press, 1985, pp. 293–335.Google Scholar
  35. 35.
    M. Jozefowicz and J. Jozefonvicz, “Antithrombogenic Polymers,”Pure &Appl. Chem. 56 (1984) 1335–1344.CrossRefGoogle Scholar
  36. 36.
    B. R. Young, Plasma Proteins: Their Role in Initiating Platelet and Fibrin Deposition on biomaterials,“in Biomaterials: Interfacial Phenomena and Applications” (S . Cooper and N. A. Peppas, ed.) Adv. in Chem. Series 199 (1982) pp.317-350.(Is this the right reference?)Google Scholar
  37. 37.
    L. M. Smith, “Cell Adhesion as Influenced by Substrate Surface Properties,”Ph.D. Thesis, University of Utah, 1979.Google Scholar
  38. 38.
    S. Hattori, J. D. Andrade, J. B. Hibbs, D. E. Gregonis, R. N. King, “Fibroblast Cell Growth on Charged Hydroxyethyl Methacrylate Polymers”, J. Colloid Interface Sci. 104 (1985) 72–78.CrossRefGoogle Scholar
  39. 39.
    J. D. Andrade, ed. Protein Adsorption Plenum Press, 1985.Google Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • J. D. Andrade
    • 1
  1. 1.College of EngineeringUniversity of UtahSalt Lake CityUSA

Personalised recommendations