Control of Polymer Surface Erosion by the use of Excipients
Polymers that contain hydrolytically labile linkages in their backbone can hydrolyze by two different mechanisms. These are bulk erosion and surface erosion. In a bulk-eroding polymer, the hydrolytic process occurs throughout the bulk of the material, whereas in surface erosion the hydrolysis is confined to the outer surface of a solid device (1).
KeywordsDrug Release Methylene Blue Surface Erosion Phthalic Anhydride Product Succinic Acid
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