Abstract
Polymers that contain hydrolytically labile linkages in their backbone can hydrolyze by two different mechanisms. These are bulk erosion and surface erosion. In a bulk-eroding polymer, the hydrolytic process occurs throughout the bulk of the material, whereas in surface erosion the hydrolysis is confined to the outer surface of a solid device (1).
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References
J. Heller, Controlled release of biologically active compounds from bioerodible polymers, Biomaterials, 1 (1980) 51–57.
J. Heller, Biodegradable polymers in controlled drug delivery, CRC Critical Reviews in Therapeutic Drug Carrier Systems 1 (1984) 39–90.
J. Heller, D.W.H. Penhale, and R. F. Helwing, Preparation of polyacetals by the reaction of divinyl ethers and polyols, J. Polymer Sci., Polym. Lett. Ed. 18 (1980) 293–297.
J. Heller, S. Y. Ng, and S. H. Pangburn, work in progress.
J. Heller, D.W.H. Penhale, and R. F. Helwing, Preparation of poly(ortho esters) by the reaction of ketene acetals and polyols, J. Polymer Sci., Polym. Lett. Ed. 18 (1980) 619–624.
J. Heller, B. K. Fritzinger, S. Y. Ng, and D.W.H. Penhale, In vitro and in vivo release of levonorgestrel from poly(ortho esters): I Linear Polymers, J. Controlled Release, 1 (1984) 225–232.
J. Heller, B. K. Fritzinger, S. Y. Ng, and D.W.H. Penhale, In vitro and in vivo release levonorgestrel from poly(ortho esters): II Crosslinked Polymers, J. Controlled Release, 1 (1984) 233–238.
R. V. Sparer, C. Shih, C. D. Ringeisen, and K. J. Himmelstein, Controlled release from erodible poly(ortho ester) drug delivery systems, J. Controlled Release 1 (1984) 23–32.
J. Heller, B. K. Fritzinger, and S. Y. Ng, work in progress.
J. Heller, D.W.H. Penhale, B. K. Fritzinger, and S. Y. Ng, Controlled release of contraceptive agents from poly(ortho esters) in G. I. Zatuchni, A. Goldsmith, J. D. Shelton, and J. J. Sciarra (Eds.) Long-Acting Contraceptive Delivery Systems, Harper and Row, New York (1984), pp. 113–128.
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© 1986 Plenum Press, New York
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Heller, J. (1986). Control of Polymer Surface Erosion by the use of Excipients. In: Chiellini, E., Giusti, P., Migliaresi, C., Nicolais, L. (eds) Polymers in Medicine II. Polymer Science and Technology, vol 34. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1809-5_26
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DOI: https://doi.org/10.1007/978-1-4613-1809-5_26
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9012-4
Online ISBN: 978-1-4613-1809-5
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