Advertisement

Control of Polymer Surface Erosion by the use of Excipients

  • Jorge Heller
Part of the Polymer Science and Technology book series (POLS, volume 34)

Abstract

Polymers that contain hydrolytically labile linkages in their backbone can hydrolyze by two different mechanisms. These are bulk erosion and surface erosion. In a bulk-eroding polymer, the hydrolytic process occurs throughout the bulk of the material, whereas in surface erosion the hydrolysis is confined to the outer surface of a solid device (1).

Keywords

Drug Release Methylene Blue Surface Erosion Phthalic Anhydride Product Succinic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    J. Heller, Controlled release of biologically active compounds from bioerodible polymers, Biomaterials, 1 (1980) 51–57.CrossRefGoogle Scholar
  2. 2.
    J. Heller, Biodegradable polymers in controlled drug delivery, CRC Critical Reviews in Therapeutic Drug Carrier Systems 1 (1984) 39–90.Google Scholar
  3. 3.
    J. Heller, D.W.H. Penhale, and R. F. Helwing, Preparation of polyacetals by the reaction of divinyl ethers and polyols, J. Polymer Sci., Polym. Lett. Ed. 18 (1980) 293–297.ADSCrossRefGoogle Scholar
  4. 4.
    J. Heller, S. Y. Ng, and S. H. Pangburn, work in progress.Google Scholar
  5. 5.
    J. Heller, D.W.H. Penhale, and R. F. Helwing, Preparation of poly(ortho esters) by the reaction of ketene acetals and polyols, J. Polymer Sci., Polym. Lett. Ed. 18 (1980) 619–624.ADSCrossRefGoogle Scholar
  6. 6.
    J. Heller, B. K. Fritzinger, S. Y. Ng, and D.W.H. Penhale, In vitro and in vivo release of levonorgestrel from poly(ortho esters): I Linear Polymers, J. Controlled Release, 1 (1984) 225–232.CrossRefGoogle Scholar
  7. 7.
    J. Heller, B. K. Fritzinger, S. Y. Ng, and D.W.H. Penhale, In vitro and in vivo release levonorgestrel from poly(ortho esters): II Crosslinked Polymers, J. Controlled Release, 1 (1984) 233–238.CrossRefGoogle Scholar
  8. 8.
    R. V. Sparer, C. Shih, C. D. Ringeisen, and K. J. Himmelstein, Controlled release from erodible poly(ortho ester) drug delivery systems, J. Controlled Release 1 (1984) 23–32.CrossRefGoogle Scholar
  9. 9.
    J. Heller, B. K. Fritzinger, and S. Y. Ng, work in progress.Google Scholar
  10. 10.
    J. Heller, D.W.H. Penhale, B. K. Fritzinger, and S. Y. Ng, Controlled release of contraceptive agents from poly(ortho esters) in G. I. Zatuchni, A. Goldsmith, J. D. Shelton, and J. J. Sciarra (Eds.) Long-Acting Contraceptive Delivery Systems, Harper and Row, New York (1984), pp. 113–128.Google Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Jorge Heller
    • 1
  1. 1.Polymer Sciences Dept.SRI InternationalMenlo ParkUSA

Personalised recommendations