Characterization of Polyurethanes for Blood-Contacting Applications
Segmented polyurethanes are widely used in commercial and experimental blood-contacting applications which include vascular prostheses, blood filters, catheters, insulation for pacemaker leads, heart valves, cardiac assist devices, and chambers for artificial hearts. The use of this family of polymers for such applications is due to the physiological acceptability, relatively good blood tolerability, relative stability over extended implant periods, and excellent physical and mechanical properties that are exhibited by these materials1.
KeywordsHard Segment Soft Segment Blood Compatibility Platelet Deposition Thrombus Deposition
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- 1.M. D. Lelah and S. L. Cooper, “Polyurethanes in Medicine,”CRC Press, Boca Raton, FL (1985).Google Scholar
- 2.G. J. Picha, D. F. Gibbons, and R. A. Auerbach, Effect of Poly-urethane Morphology on Blood Coagulation, J. Bioeng., 2:301 (1978).Google Scholar
- 4.A. Takahara, J. Tashita, T. Kajiyama, and M. Takayanagi, Blood compatibility and microphase-separated structure of segmented poly(urethaneureas) with various soft segment components, Rep. Prog. Polym. Phys. Jpn., 25:841 (1982).Google Scholar
- 13.J. A. Miller, K. K. S. Hwang, and S. L. Cooper, Properties of polyether-polyurethane anionomers, J. Macromol. Sci. Phys., B22:321 (1983).Google Scholar
- 16.M. D. Lelah, T. G. Grasel, J. A. Pierce, and S. L. Cooper, Ex vivo interactions and surface property relationships of polyether-urethanes, J. Biomed. Mater. Res., submitted for publication (1985).Google Scholar
- 17.M. D. Lelah, Ph.D. Dissertation, University of Wisconsin-Madison (1984).Google Scholar
- 19.E. W. Merrill, V. sa da Costa, E. W. Salzman, D. Brier-Russell, L. Kuchner, D. F. Waugh, G. Trudel, S. Stopper, and V. Vitale, A critical study of segmented polyurethanes, in: “Biomaterials: Interfacial Phenomena and Applications,”S. L. Cooper and N. A. Peppas, eds., Adv. Chem. Ser. 199:95 (1982).CrossRefGoogle Scholar
- 20.R. S. Wilson, M. D. Lelah, and S. L. Cooper, Blood-material interactions: Assessment of in vitro and in vivo test methods, in: “Techniques in Biocompatibility Testing,”D. F. Williams, ed., CRC Press, Boca Raton, FL (1985).Google Scholar