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Modern Concepts in Gastroenterology pp 261–284Cite as

Hepatitis and Immunization

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Part of the book series: Topics in Gastroenterology ((TGEN))

Abstract

Hepatitis is always a topic of great interest to health workers, not least because they are at risk of acquiring this infection from their patients. Hepatitis B, the most dangerous of the three known hepatitis viruses, is now preventable by immunization. Eradication of the disease on a world scale presents a continuing challenge but should be possible in the future. Hepatitis A is a benign enteric viral infection for which there is every prospect of an effective vaccine in the near future. On the other hand, control of non-A, non-B hepatitis awaits identification of the causative agent.

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References

  1. Sobeslavsky O: Prevalence of markers of hepatitis B virus infection in various countries: A WHO collaborative study. Bull Wld Hlth Org 1980;58:621–628.

    CAS  Google Scholar 

  2. Robinson WS: Biology of human hepatitis viruses, pp 863–910, in Zakim D, Boyer TD (eds.): Hepatology. A Textbook of Liver Disease. Philadelphia, WB Saunders Co, 1982.

    Google Scholar 

  3. Miyakawa Y, Mayumi M: Characterization and clinical significance of HBeAg, in Vyas GN, Cohen SN, Schmid R (eds): Viral Hepatitis. Philadelphia, Franklin Institute Press, 1978, pp. 193–201.

    Google Scholar 

  4. Beasley RP, Hwang L-Y, Lee GC-Y, et al: Prevention of perinatally transmitted hepatitis B virus infections with hepatitis B immune globulin and hepatitis B vaccine. Lan cet 1983;2:1099–1102.

    CAS  Google Scholar 

  5. Heathcote J, Gateau PH, Sherlock S: Role of hepatitis B antigen carriers in non-parenteral transmission of the hepatitis B virus. Lancet 1974;2:370–372.

    Article  PubMed  CAS  Google Scholar 

  6. Szmuness W, Much MI, Prince AM, et al: On the role of sexual behaviour in the spread of hepatitis B infection. Ann Intern Med 1975;83:489–495.

    PubMed  CAS  Google Scholar 

  7. Burrell CJ, MacKay P, Greenway PJ, Hofschneider PH, Murray K: Expression in Escherichia coli of hepatitis B virus DNA sequences cloned in plasmic. pBR322. Nature 1979;279:43–47.

    Article  PubMed  CAS  Google Scholar 

  8. Charnay P, Gervais M, Louise A, Galibert F, Tiollais P: Biosynthesis of hepatitis B virus surface antigen in Escherichia coli. Nature 1980;286:893–895.

    Article  PubMed  CAS  Google Scholar 

  9. McAleer WJ, Buynak EB, Maigetter RZ, et al: Human hepatitis B vaccine from recombinant yeast. Nature 1984;307:178–180.

    Article  PubMed  CAS  Google Scholar 

  10. Smith GL, Macket M, Moss B: Infectious vaccinia virus recombinants that express hepatitis B virus surface antigen. Nature 1983;302:490–495.

    Article  PubMed  CAS  Google Scholar 

  11. Krugman S, Overby LR, Mushalwar IK, Ling C-M, Frosner GG, Deinhardt F: Viral hepatitis, type B. Studies on natural history and prevention reexamined. N Engl J Med 1979;300:101–106.

    Article  PubMed  CAS  Google Scholar 

  12. Purcell RH, Gerin JL: Hepatitis B vaccines: A status report, in Vyas G, Cohen SH, Schmid R (eds): Viral Hepatitis. Philadelphia, Franklin Institute Press, 1978, pp. 491–505.

    Google Scholar 

  13. Hilleman MR, Bertland AU, Buynak ER, et al: Clinical laboratory studies of HBsAg vaccine, in Vyas G, Cohen SN, Schmid R (eds): Viral Hepatitis. Philadelphia, Franklin Institute Press, 1978, pp. 525–537.

    Google Scholar 

  14. Maupas P, Goudeau A, Coursaget P, Drucker J, Bagros P: Immunization against hepatitis B in man. Lancet 1976;1:1367–1370.

    Article  PubMed  CAS  Google Scholar 

  15. Szmuness W, Stevens CE, Harley EJ, et al: Hepatitis B vaccine. Demonstration of efficacy in a controlled clinical trial in a high-risk population in the United States. N Engl J Med 1980;303:833–841.

    Article  PubMed  CAS  Google Scholar 

  16. Sacks HS, Rose DN, Chalmers TC: Should the risk of acquired immunodeficiency syndrome deter hepatitis B vaccination? A decision analysis. JAMA 1984;252:3375–3377.

    Article  PubMed  CAS  Google Scholar 

  17. Szmuness W, Stevens CE, Harley EJ, et al: Hepatitis B vaccine in medical staff of hemodialysis units. Efficacy and subtype cross-protection. N Engl J Med 1982;307:1481–1486.

    Article  PubMed  CAS  Google Scholar 

  18. Crosnier J, Jungers P, Courouce A-M, et al: Randomized placebo-controlled trial of hepatitis B surface antigen vaccine in French haemodialysis units; 1, medical staff. Lan cet 1981;1:455–459.

    CAS  Google Scholar 

  19. Coutinho RA, Lelie N, Albrecht-Van Lent P, et al: Efficacy of a heat inactivated hepatitis B vaccine in male homosexuals: Outcome of a placebo-controlled double blind trial. Br Med J 1983;286:1303–1308.

    Article  Google Scholar 

  20. Desmyter J, Colaert J, De Groote G, et al: Efficacy of heat-inactivated hepatitis B vaccine in haemodialysis patients and staff. Lancet 1983;2:1323–1327.

    Article  PubMed  CAS  Google Scholar 

  21. Miller KD, Gibbs RD, Mulligan MM, Nutman TB, Francis DP: Intradermal hepatitis B virus vaccine: Immunogenicity and side-effects in adults. Lancet 1983;2:1454–1456.

    Article  PubMed  CAS  Google Scholar 

  22. Maupas P, Chiron J-P, Barin F, et al: Efficacy of hepatitis B vaccine in prevention of early HBsAg carrier state in children. Controlled trial in an endemic area (Senegal). Lan cet 1981;1:289–292.

    CAS  Google Scholar 

  23. Maupas P, Goudeau A, Coursaget P, Drucker J, Bagros P: Hepatitis B vaccine: Efficacy in high-risk settings. Intervirology 1978;10:196–208.

    Article  PubMed  CAS  Google Scholar 

  24. Szmuness W, Stevens CE, Harley EJ, Zang EA, Taylor PE, Alter HJ: The Dialysis Vaccine Trial Group. The immune response of healthy adults to a reduced dose of hepatitis B vaccine. J Med Virol 1981;8:123–129.

    PubMed  CAS  Google Scholar 

  25. Lindsay KL, Herbert DA, Gitnick GL: Hepatitis B vaccine: Low postvaccination immunity in hospital personnel. Gastroenterology 1985;88:1675.

    Google Scholar 

  26. Bramwell SP, Tsakiris DJ, Briggs JD, et al: Dinitrochlorobenzene skin testing predicts response to hepatitis B vaccine in dialysis patients. Lancet 1985;1:1412–1415.

    Article  PubMed  CAS  Google Scholar 

  27. Crosnier J, Jungers P, Courouce AM, et al: Randomized placebo-controlled trial of hepatitis B surface antigen vaccine in French haemodialysis units: 11, Haemodialysis patients. Lancet 1981;1:797–800.

    Article  PubMed  CAS  Google Scholar 

  28. Maupas P, Goudeau A, Coursaget P, et al: Vaccine against hepatitis B-18 months prevention in a high-risk setting. Med Microbiol Immunol 1978;166:109–18.

    Article  PubMed  CAS  Google Scholar 

  29. Stevens CE, Szmuness W, Goodman AI, Weseley SA, Fotino M: Hepatitis B vaccine: Immune response in haemodialysis patients. Lancet 1980;2:1211–1213.

    Article  PubMed  CAS  Google Scholar 

  30. Gust ID, Lucas CR: Immunization against hepatitis B. Aust Family Phys 1983;12:657–660.

    CAS  Google Scholar 

  31. Craven DE, Kunches LM, Dienstag JL, et al: Analysis of nonresponsiveness to hepatitis B in health care workers. Hepatology 1984;4:1077.

    Google Scholar 

  32. Szmuness W, Stevens CE, Zang EA, Harley EJ, Kellner A: A controlled clinical trial of the efficacy of hepatitis B vaccine (Heptavax-B): A final report. Hepatology 1981;1:377–385.

    Article  PubMed  CAS  Google Scholar 

  33. Hoofnagle JH, Seeff LB, Bales ZB, Wright EC, Zimmerman HJ. The Veterans Administration Cooperative Study Group: Passive-active immunity from hepatitis B immune globulin: Re-analysis of a Veteran’s Administration co-operative study of needle-stick hepatitis. Ann Intern Med 1979;91:813–818.

    PubMed  CAS  Google Scholar 

  34. Beasley RP, Hwang L-Y, Lin C-C, et al: Hepatitis B immune globulin (HBIG) efficacy in the interruption of perinatal transmission of hepatitis B virus carrier state. Lancet 1981;2:388–393.

    Article  PubMed  CAS  Google Scholar 

  35. Szmuness W, Stevens CE, Oleszko WR, Goodman A: Passive-active immunization against hepatitis B: Immunogenicity studies in adult Americans. Lancet 1981;1:575–577.

    Article  PubMed  CAS  Google Scholar 

  36. Francis DP, Hadler SC, Thompson SE, et al: The prevention of hepatitis B with vaccine. Report of the Centers for Disease Control multi-center efficacy trial among homosexual men. Ann Intern Med 1982;97:362–366.

    PubMed  CAS  Google Scholar 

  37. Mulley AG, Silverstein MD, Dienstag JL: Indications for use of hepatitis B vaccine, based on cost-effectiveness analysis. N Engl J Med 1982;307:644–652.

    Article  PubMed  CAS  Google Scholar 

  38. Chin J: The use of hepatitis B virus vaccine. N Engl J Med 1982;307:678–679.

    Article  PubMed  CAS  Google Scholar 

  39. Editorial, Costs and benefits of hepatitis B vaccination. Lancet 1982;2:1195–1196.

    Google Scholar 

  40. Coates RA, Rankin JG: Cost without benefit? The introduction of hepatitis B vaccine in Canada. Can Med Assoc J 1983;128:1158–1160.

    PubMed  CAS  Google Scholar 

  41. Goldsmith MF: Crossing “threshold” of hepatitis B control awaits greater vaccine use. JAMA 1984;251:2765–2772.

    Article  PubMed  CAS  Google Scholar 

  42. Beasley RP, Hwang L-Y: Postnatal infectivity of hepatitis B surface antigen carrier mothers. J Infect Dis 1983;147:185–190.

    Article  PubMed  CAS  Google Scholar 

  43. Burrell CJ, Cameron AS, Hart G, Melbourne J, Beal RW: Hepatitis B reservoirs and attack rates in an Australian community. A basis for vaccination and cross-infection policies. Med J Aust 1983;2:492–496.

    PubMed  CAS  Google Scholar 

  44. Jovanovich JF, Saravolatz LD, Arking LM: The risk of hepatitis B among select employee groups in an urban hospital. JAMA 1983;250:1893–1894.

    Article  PubMed  CAS  Google Scholar 

  45. Grady GF: Hepatitis B immunity in hospital staff targeted for vaccination. Role of screening tests in immunization programs. JAMA 1982;248:2266–2269.

    Article  PubMed  CAS  Google Scholar 

  46. Dienstag JL, Stevens CE, Bhan AK, Szmuness W: Hepatitis B vaccine administered to chronic carriers of hepatitis B surface antigen. Ann Intern Med 1982;96:575–579.

    PubMed  CAS  Google Scholar 

  47. Purcell RH, Gerin JL: Prospects for second and third generation hepatitis B vaccines. Hepatology 1985;5:159–163.

    Article  PubMed  CAS  Google Scholar 

  48. McAleer WJ, Markus HZ, Wampler DE, et al: Vaccine against human hepatitis B virus prepared from antigen derived from human hepatoma cells in culture. Proc Soc Exp Biol Med 1984;175:314–319.

    PubMed  CAS  Google Scholar 

  49. Scolnick EM, McLean AA, West DJ, McAleer WJ, Miller WJ, Buynak EB: Clinical evaluation in healthy adults of a hepatitis B vaccine made by recombinant DNA. JAMA 1984;251:2812–2815.

    Article  PubMed  CAS  Google Scholar 

  50. Moss B, Smith GL, Gerin JL, Purcell RH: Live recombinant vaccinia virus protects chimpanzees against hepatitis B. Nature 1984;311:67–69.

    Article  PubMed  CAS  Google Scholar 

  51. Provost PJ, Hilleman MR: An inactivated hepatitis A virus vaccine prepared from infected marmoset liver. Proc Soc Exp Biol Med 1978;159:201–203.

    PubMed  CAS  Google Scholar 

  52. Anderson BN, Coulepes AG, Gust ID: Toward a hepatitis A vaccine. A review. J Hyg (Lond) 1984;3:269–276.

    Article  Google Scholar 

  53. Jacobson IM, Dienstag JL: Viral hepatitis vaccines. Annu Rev. Med 1985;36:241–261.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. The University of Sydney and Gastroenterology Unit, Westmead Hospital, Westmead, NSW, Australia, 2145

    Geoffrey C. Farrell

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  1. Geoffrey C. Farrell
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Editor information

Editors and Affiliations

  1. The University of Alberta, Edmonton, Alberta, Canada

    Alan B. R. Thomson M.D.

  2. Queen’s University, Kingston, Ontario, Canada

    L. R. DaCosta M.D.

  3. Department of Gastroenterology, Victoria Hospital, London, Ontario, Canada, N6A 4G5

    William C. Watson M.D.

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© 1986 Plenum Publishing Corporation

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Farrell, G.C. (1986). Hepatitis and Immunization. In: Thomson, A.B.R., DaCosta, L.R., Watson, W.C. (eds) Modern Concepts in Gastroenterology. Topics in Gastroenterology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1789-0_15

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  • DOI: https://doi.org/10.1007/978-1-4613-1789-0_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9002-5

  • Online ISBN: 978-1-4613-1789-0

  • eBook Packages: Springer Book Archive

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