Abstract
It has long been appreciated that the function of one ventricle can influence the performance of the other. This ventricular interaction can occur via three mechanisms: 1) Since the two ventricles are arranged in series, if the output of the right ventricle decreases, then preload to the left ventricle necessarily declines; conversely, if performance of the left ventricle is decreased, then afterload to the right ventricle may be increased. 2) Both ventricles are enclosed in the pericardium, which may cause restriction to ventricular filling even at physiologic pressures {1}. Expansion of one ventricle, therefore, may result in compression of the other with an apparent decrease in compliance {2}. 3) Finally, the two ventricles share a common wall, the ventricular septum, which allows direct mechanical interaction between the two chambers. In this chapter we will deal primarily with this latter mechanism while recognizing that ventricular interaction mediated through the septum is modulated by the pericardium. Following a review of some pertinent historical and anatomic data, we will deal in turn with a number of the major clinical states in which ventricular interdependence is demonstrable via this septal mechanism.
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References
Tyberg JV, Taichman GC, Smith ER, Douglas NWS, Smiseth OA, Keon WJ: The relation between pericardial pressure and right atrial pressure: An intraoperative study. Circulation 73:428–432, 1986.
Braunwald E, Ross J Jr: The ventricular end-diastolic pressure. AmJ Med 34:147–150, 1963 (editorial).
Bernheim D: De l’asystolie veineuse dans l’hyper trophie due coeur gauche par stenose concomitante du ventricule droit. Rev Med 39:785–794, 1910.
Henderson Y, Prince AL: The relative systolic discharges of the right and left ventricles and their bearing on pulmonary congestion and depletion. Heart 5:217–226, 1914.
Armour JA, Randall WC: Structural basis for cardiac function. AmJ Physiol 218:1517–1523, 1970.
Brown OR, Harrison DC, Popp RL: Echocardiographic study of right ventricular hypertension producing asymmetric septal hypertrophy. Circulation 48(Suppl IV):IV-47, 1973 (abstract).
Bemis CE, Serur JR, Borkenhagen D, Sonnenblick EH, Urschel CW: Influence of right ventricular filling pressure on left ventricular pressure and dimension. Circ Res 34:498–504, 1974.
Santamore WP, Lynch PR, Meier G, Jeckman J, Bove AA: Myocardial interaction between the ventricles. J Appl Physiol 41:362–368, 1976.
Popp RL, Wolfe SB, Hirata T, Feigenbaum H: Estimation of right and left ventricular size by ultrasound. A study of the echoes from the interventricular septum. Am J Cardiol 24:523, 1969.
Kerber RE, Dippel WF, Abboud FM: Abnormal motion of the interventricular septum in right ventricular volume overload. Circulation 48:86–96, 1973.
Pearlman AS, Clark CE, Henry WL, Morganroth J, Itscoitz SB, Epstein SE: Determinants of ventricular septal motion. Influence of relative right and left ventricular size. Circulation 54: 83–91, 1976.
Laurenceau JL, Dumesnil JG: Right and left ventricular dimensions as determinants of ventricular septal motion. Chest 69:388–393, 1976.
Weyman AE, Wann S, Feigenbaum H, Dillon JC: Mechanism of abnormal septal motion in patients with right ventricular volume overload. A cross-sectional echocardiographic study. Circulation 54:179–186, 1976.
Kingma I, Tyberg JV, Smith ER: Effects of diastolic trans-septal pressure gradient on ventricular septal position and motion. Circulation 68:1304–1314, 1983.
Molaug M, Geiran O, Stokland O, Thorvaldson J, Ilebekk A: Dynamics of the interventricular septum and free ventricular walls during blood volume expansion and selective right ventricular volume loading in dogs. Acta Physiol Scand 116:245–256, 1982.
Popio KA, Gorlin R, Teichholz LE, Cohn PF, Bechtel D, Herman MV: Abnormalities of left ventricular function and geometry in adults with an atrial septal defect. Ventriculographic, hemodynamic and echocardiographic studies. AmJ Cardiol 36:302–308, 1975.
Dexter L: Atrial septal defect. Br Heart J 18:209–225, 1956.
Moulopoulos SD, Sarcas A, Stametelopoulos S, Arealis E: Left ventricular performance during by-pass or distension of the right ventricle. Circ Res 17:484–491, 1965.
Taylor RR, Covell JW, Sonnenblick EH, Ross J Jr: Dependence of ventricular distensibility on filling of the opposite ventricle. Am J Physiol 213:711–718, 1967.
Waller BF, Smith ER, Blackbourne BD, Arce FP, Sarkar NN, Roberts WC: Congenital hypoplasia of portions of both right and left ventricular myocardial walls: Clinical and necropsy observations in two patients with parchment heart syndrome. Am J Cardiol 46:885–891, 1980.
Rao BS, Cohn KE, Eldridge FL, Hancock EW: Left ventricular failure secondary to chronic pulmonary disease. AmJ Med 45:229–241, 1968.
Stool EW, Mullins CB, Leshin SJ, Mitchell JH: Dimensional changes of the left ventricle during acute pulmonary arterial hypertension in dogs. Am} Cardiol 33:868–875, 1974.
Visner MS, Arentzen CE, O’Connor MJ, Larson EV, Anderson RW: Alterations in left ventricular three-dimensional dynamic geometry and systolic function during acute right ventricular hypertension in the conscious dog. Circulation 67:353–365, 1983.
Olsen CO, Tyson GS, Maier GW, Spratt JA, Davis JW, Rankin JS: Dynamic ventricular interaction in the conscious dog. Circ Res 52:85–104, 1983.
Badke FR: Left ventricular dimensions and function during right ventricular pressure overload. Am J Physiol 11:H611–H618, 1982.
Slutsky RA, Peck WW, Mancini GB: The effect of pulmonic and aortic constriction on regional left ventricular thickening dynamics, geometry and the radius of septal curvature. Analysis by gated computed transmission tomography. Invest Radiol 19:374–379, 1984.
Tanaka H, Tei C, Nakao S, Tahara M, Sakurai S, Kashima T, Kanehisa T: Diastolic bulging of the interventricular septum toward the left ventricle. An echocardiographic manifestation of negative interventricular pressure gradient between left and right ventricles during diastole. Circulation 62:558–563, 1980.
Molaug M, Stokland O, Ilebekk A, Lekven J, Kiil F: Myocardial function of the interventricular septum. Effects of right and left ventricular pressure loading before and after pericardiotomy in dogs. Circ Res 49:52–61, 1981.
Smith ER, Kingma I, Smiseth OA, MacDonald RP, Groves G, Pawlak C, Kondo C, Tyberg JV: Ventricular septal responses to acute constriction of the pulmonary artery in conscious dogs. Am Rev Respir Dis 131:A57, 1985 (abstract).
Tyan T, Petrovic O, Dillon JC, Feigenbaum H, Conley MJ, Armstrong WF: An echocardiographic index for separation of right ventricular volume and pressure overload. J Am Coll Cardiol 5:918–924, 1985.
Shimada R, Takeshita A, Nakamura M: Noninvasive assessment of right ventricular systolic pressure in atrial septal defect: Analysis of the end-systolic configuration of the ventricular septum by two-dimensional echocardiography. Am J Cardiol 53:1117–1123,1984.
Meyer RA: Pediatric Echocardiography. Philadelphia, Lea and Febiger, 1977.
Ieri A, Zipoli A: Abnormal diastolic motion of interventricular septum during inspiratory phase. Echocardiographic study. Br Heart J 43:702–704, 1980.
Brinker JA, Weiss JL, Lappé DL, Rabson JL, Summer WR, Permutt S, Weisfeldt ML: Leftward septal displacement during right ventricular loading in man. Circulation 61:626–633, 1980.
Guzman PA, Maughan WL, Yin FC, Eaton LW, Brinker JA, Weisfeldt ML, Weiss JL: Trans-septal pressure gradient with leftward septal displacement during the Mueller maneuver in man. Br Heart J 46:657--662, 1981.
Kingma I, Smiseth OA, Belenkie I, MacDonald RP, Knudtson ML, Tyberg JV, Smith ER: Ventricular septal dynamics in response to altered trans-septal pressure in man. J Am Coll Cardiol 5:511, 1985 (abstract).
Candell-Riera J, Del Castillo G, PermanyerMiralda G, Soler-Soler J: Echocardiographic features of the interventricular septum in chronic constrictive pericarditis. Circulation 57:1154–1158, 1978.
Pool PE, Seagren SC, Abbasi AS, Charuzi Y, Kraus R: Echocardiographic manifestations of constrictive pericarditis: Abnormal septal motion. Chest 68:684–688, 1975.
D’Cruz IA, Levinski R, Anagnostopoulos C, Cohen HC: Echocardiographic diagnosis of partial constriction of the left ventricle. Radiol 127:755–756, 1978.
Tei C, Child JS, Tanaka H, Shah PM: Atrial systolic notch on the interventricular septal echogram: An echocardiographic sign of constrictive pericarditis. J Am Coll Cardiol 1:907, 1983.
Feigenbaum H: Echocardiography. Philadelphia, Lea and Febiger, 1985.
Dillon JC, Chang S, Feigenbaum H: Echocardiographic manifestations of left bundle branch block. Circulation 49:876–880, 1974.
McDonald IG: Echocardiographic demonstration of abnormal motion of the interventricular septum in left bundle branch block. Circulation 48:272, 1973.
Gomes JA, Damato AN, Akhtar M, Dhatt MS, Calon AH, Reddy CP, Moran HE: Ventricular septal motion and left ventricular dimensions during abnormal ventricular activation. Am J Cardiol 39:641, 1977.
Little WC, Reeves RC, Arciniegas J, Katholi RE, Rogers EW: Mechanism of abnormal inter-ventricular septal motion during delayed left ventricular activation. Circulation 65:1486–1491, 1983.
Force T, Bloomfield P, O’Boyle JE, Pietro DA, Dunlap RW, Khuri SF, Parisi AF: Quantitative two-dimensional echocardiographic analysis of motion and thickening of the interventricular septum after cardiac surgery. Circulation 68: 1013–1020, 1983.
Waggoner AD, Shah AA, Schuessler JS, Crawford ES, Nelson JG, Miller RR, Quinones MA: Effect of cardiac surgery on ventricular septal motion: Assessment by intraoperative echocardiography and cross-sectional two-dimensional echocardiography Am Heart J 104:1271–1278, 1982.
Kerber RE, Litchfield R: Postoperative abnormalities of interventricular septal motion: Two-dimensional and M-mode echocardiographic correlations. Am Heart J 104:263–268, 1982.
Lindsay J Jr, Nolan NG, Kotlyarov EV, Goldstein SA, Bacos JM: Radionuclide evaluation of the interventricular septum following coronary artery bypass surgery. Radio J 42:489–493, 1982.
Righetti A, Crawford MH, O’Rourke RA, Schelbert H, Daily PO, Ross J Jr: Interventricular septal motion and left ventricular function after coronary bypass surgery. Evaluation with echocardiography and radionuclide angiography. Ana J Cardiol 39:372–377, 1977.
Vignola PA, Boucher CA, Curfman GD, Walker HJ, Shea WH, Dinsmore RE, Pohost GM: Abnormal interventricular septal motion following cardiac surgery: Clinical, surgical, echocardiographic and radionuclide correlates. Am Heart J 97:27–34, 1979.
Schabelman SE, Jacobson JG, Schulz EE, Jutzy RV: Pericardial closure and paradoxic septal motion after surgery. Southern Med J 74:1353–1356,1981.
Weyman AE, Heger JJ, Kronik G, Wann LS, Dillon JC, Feigenbaum H: Mechnism of paradoxical early diastolic septal motion in patients with mitral stenosis: A cross-sectional echocardiographic study. Am J Cardiol 40:691–699, 1977.
Thompson CR, Kingma I, MacDonald RP, Belenkie I, Tyberg JV, Smith ER: Trans-septal pressure gradient and diastolic ventricular septal motion in patients with mitral stenosis. Circulation 76:974–980, 1987.
Molaug M, Geiran 0, Kiil F: Dynamics of the interventricular septum and free ventricular walls during selective left ventricular volume loading in dogs. Acta Physiol Scand 119:81–89, 1983.
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© 1988 Kluwer Academic Publishers
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Smith, E.R., Tyberg, J.V. (1988). Ventricular Interdependence. In: Konstam, M.A., Isner, J.M. (eds) The Right Ventricle. Developments in Cardiovascular Medicine, vol 83. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1773-9_3
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DOI: https://doi.org/10.1007/978-1-4613-1773-9_3
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