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Echocardiography During Reversible Ischemia in Animal Models

  • Natesa G. Pandian
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 80)

Abstract

In recent years, advances in echocardiographic techniques have made echocardiography an ideal method to study the effects of myocardial ischemia on myocardial structure and function. This chapter reviews the observations made by the use of M-mode echocardiography, two-dimensional echocardiographic imaging, and Doppler echocardiography in the study of the left ventricle during transient or acute myocardial ischemia in animal investigations.

Keywords

Mitral Regurgitation Coronary Stenosis Aortic Flow Left Ventricular Myocardium Transient Ischemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Stefan G, Bing RJ. Echocardiographic findings in experimental myocardial infarction of the posterior left ventricular wall. Am J Cardiol 1972;30:629.PubMedCrossRefGoogle Scholar
  2. 2.
    Kerber RE, Abboud FM. Echocardiographic detection of regional myocoardial infarction. Circulation 1973;47:997.PubMedGoogle Scholar
  3. 3.
    Komer RR, Edalji A, Hood WB. Effects of nitroglycerine on echocardiographic measurements of left performance during acute coronary ischemia. Circulation 1979;59:926.PubMedGoogle Scholar
  4. 4.
    Meltzer MS, Woythaler JN, Buda AJ, et al. Two-dimensional echocardiographic quantification of infarct size alteration by pharmacologic agents. Am J Cardiol 1979;44:257.PubMedCrossRefGoogle Scholar
  5. 5.
    Nieminen M, Parisi A, O’Boyle JE, Folland ED, Khuri S, Kloner RA. Serial evaluation of myocardial thickening and thinning in acute experimental infarction: identification and quantification using two-dimensional echocardiography. Circulation 1982;66:174.PubMedCrossRefGoogle Scholar
  6. 6.
    Pandian N, Koyanagi S, Skorton D, Collins S, Marcus M, Kerber R. Relations between two-dimensional echocardiographic wall thickening abnormalities, myocardial infarct size and coronary risk area in normal and hypertrophied myocardium in dogs. Am J Cardiol 1983;52:131 B.CrossRefGoogle Scholar
  7. 7.
    Wyatt HL, Meerbaum S, Heng MK, Rit J, Gueret P, Corday E. Experimental evaluation of the extent of myocardial dysynergy and infarct size by two-dimensional echocardiography. Circulation 1981;63:607.PubMedCrossRefGoogle Scholar
  8. 8.
    Lieberman AN, Weiss JL, Jugdutt BI, et al. Two-dimensional echocardiography and infarct size: relationship of regional wall motion and thickening to the extent of myocardial infarction in the dog. Circulation 1981;63:739.PubMedCrossRefGoogle Scholar
  9. 9.
    Pandian N, Kerber R. Two-dimensional echocardiography in experimental coronary stenosis. I. Sensitivity and specificity in detecting transient myocardial dyskinesis: comparison with sonomicrometers. Circulation 1982;66:597.PubMedCrossRefGoogle Scholar
  10. 10.
    Rosoff M, Funai J, Wang SS, Pandian NG. Left ventricular diastolic filling dynamics in acute myocardial infarction. J Am Coll Cadiol 1986;7:227 A.Google Scholar
  11. 11.
    Pandian NG, Wang SS, Funai J, Roberts D, Caldeira M, Mclnerney K. Pulsed and color flow Doppler study of mitral regurgitation in experimental myocardial ischemia: influence of site and extent of left ventricular dysynergy and papillary muscle vulnerability. Circulation 1985;72:III–206.Google Scholar
  12. 12.
    Tennant R, Wiggers CJ. The effect of coronary occlusion on myocardial contraction. Am J Physiol 1935;112:351.Google Scholar
  13. 13.
    Wyatt HL, Forrester JS, Da Luz PL, et al. Functional abnormalities in non-occluded regions of myocardium after experimental coronary occlusion. Am J Cardiol 1976;37:366.PubMedCrossRefGoogle Scholar
  14. 14.
    Heikkila J, Tabakin BS, Hugenholitz PG. Quantification of myocardial function in normal and infarcted regions of the left ventricle. Cardiovasc Res 1972;6:516.PubMedCrossRefGoogle Scholar
  15. 15.
    Theroux P, Franklin D, Ross J Jr, et al. Regional myocardial function and electrophysiological alterations after brief coronary artery occlusion in conscious dogs. J Clin Invest 1975;56:978.CrossRefGoogle Scholar
  16. 16.
    Heyndrickx G, Millar RW, McRitchie RJ, et al. Regional myocardial function and electrophysiological alterations after brief coronary artery occlusion in conscious dogs. J Clin Invest 1975;56:978.PubMedCrossRefGoogle Scholar
  17. 17.
    Tabooks CJ, Randall WC. Local ventricular bulging after acute coronary occlusion. Am J Physiol 1961;201:451.Google Scholar
  18. 18.
    Schelbert HR, Corbell J, Burns JW, et al. Observations on factors affecting local forces in the left ventricular wall during acute myocardial ischemia. Circ Res 1971;39:306.Google Scholar
  19. 19.
    Yosidar S. Experimental studies of coronary insufficiency. 1. Changes in myocardial contractility in the ischemic area of the ventricle following acute coronary occlusion. Jpn Circ J 1969;33:1253.Google Scholar
  20. 20.
    Kerber RE, Marcus ML, Wilson R, et al. Effects of acute coronary occlusion on the motion and perfusion of the normal and ischemic interventricular septum: an experimental echocar-diographic study. Circulation 1976;54:928.PubMedGoogle Scholar
  21. 21.
    Kerber RE, Marcus ML, Ehrhardt J, et al. Correlation between echocardiographically demonstrated segmental dyskinesis and regional myocardial perfusion. Circulation 1975;52:1097.PubMedGoogle Scholar
  22. 22.
    Kerber RE, Marcus M, Abbound FM. Effect of inotropic agents on the localized dyskinesis of acutely ischemic myocardium: an experimental ultrasound study. Circulation 1974;49:1038.PubMedGoogle Scholar
  23. 23.
    Gaasch WH, Bernard SA. The effect of acute changes in coronary blood flow on left ventricular end diastolic wall thickness: an echocardiographic study. Circulation 1977;56: 593.PubMedGoogle Scholar
  24. 24.
    Pandian NG, Kieso RA, Kerber RE. Two-dimensional echocardiography in experimental coronary stenosis. II. Relationships between systolic wall thinning and regional myocardial perfusion in severe coronary stenosis. Circulation 1982;66:603.PubMedCrossRefGoogle Scholar
  25. 25.
    Pandian NG, Kieso RA, Kerber RE. Relationship between myocardial blood flow by layer and abnormalities of wall thinning on two-dimensional echocardiography. Am J Cardiol 1982;49:918.CrossRefGoogle Scholar
  26. 26.
    Pandian N, Skorton D, Collins S, Falsetti H, Burke E, Kerber RE. Heterogeneity of left ventricular segmental wall thickening and excursion of two-dimensional echocardiograms of normal humans. Am J Cardiol 1983;51:1667.PubMedCrossRefGoogle Scholar
  27. 27.
    Weyman AE, Franklin TD, Hogan RD, et al. Importance of temporal heterogeneity in assessing the contraction abnormalities associated with acute myocardial ischemia. Circulation 1984;70:102.PubMedCrossRefGoogle Scholar
  28. 28.
    Marier DL, Gibson DG. Limitations of two frame method for displaying regional left ventricular wall motion in man Br Heart J 1980;44:555.PubMedCrossRefGoogle Scholar
  29. 29.
    Pandian NG, Skorton DJ, Collins SM, Koyanagi S, Marcus ML, Kerber RE. Myocardial infarct size threshold for two-dimensional echocardiographic detection: sensitivity of systolic wall thickening and endocardial motion abnormalities in small versus large infarction. Am J Cardiol 1985;55:551.PubMedCrossRefGoogle Scholar
  30. 30.
    Kavanaugh KM, Carlson RE, Pace DP, Krause LC, Gallagher KP, Buda AJ. The extent of left ventricular dysfunction differs between supply-type and demand-type ischemia. Clin Res 1987;35:290A.Google Scholar
  31. 31.
    Grossman W, Mann T. Evidence for impaired left ventricular relaxation during acute ischemia in man. Eur J Cardio 1970;7:239.Google Scholar
  32. 32.
    Levine H, Gaasch W. Diastolic compliance of the left ventricle. Mod Concepts Cardiovasc Dis 1970;47:95.Google Scholar
  33. 33.
    Funai JT, Pandian NG, Lojeski E, Levine HL. Heterogeneity of regional diastolic filling in normal left ventricle. J Am Coll Cardiol 1985;5:426.Google Scholar
  34. 34.
    Funai J, Wang SS, Pandian N. Effect of graded reductions in regional myocardial blood flow on regional diastolic left ventricular wall dynamics. J Am Coll Cardial 1987;9:218A.Google Scholar
  35. 35.
    Noble MIM. Trenchard D, Giuz A. Left ventricular ejection in conscious dogs. Circ Res 1966;19:139.Google Scholar
  36. 36.
    Jewitt D, Gabe I, Mills C, Maurer B, Thomas M, Shillingford J. Aortic velocity and acceleration measurements in assessment of coronary heart disease. Eur J Cardiol 1974;1:299.PubMedGoogle Scholar
  37. 37.
    Wang SS, Funai J, Pandian NG. Cavity area-flow velocity loops: a new Doppler echocardiographic approach to assess left ventricular function in myocardial ischemia. Circulation 1985;72:III–353.Google Scholar
  38. 38.
    Werner M, Funai J, Wang SS, Pandian NG. How sensitive is stress Doppler echocardiography in the detection of transient ischemia in coronary stenosis? J Am Coll Cardiol 1986;7:230A.Google Scholar
  39. 39.
    Fisher DC, Voyles WF, Sikes W, Greene ER. Left ventricular filling patterns during ischemia: an echo/Doppler study in open-chest dogs. J Am Coll Cardiol 1985;5:426.Google Scholar
  40. 40.
    Pandian NG, Funai J, Wang SS, Lowell B. Effect of regional ischemia on diastolic left ventricular intracavitary flow vortex: color Doppler and contrast echocardiographic studies. J Am Coll Cardiol 1986;7:147A.Google Scholar
  41. 41.
    Hsiung MC, Zachariah Z, Nanda NC, Roitman DI. Color Doppler assessment of mitral regurgitation induced by supine exercise in ischemic heart disease. Circulation 1985;72:III–58.Google Scholar
  42. 42.
    De Maria AN, Bommer WJ, Riggs K, et al. Echocardiographic visualization of myocardial perfusion by left heart and intracoronary injection of echo contrast agents. Circulation 1981;62:III–143.Google Scholar
  43. 43.
    Armstrong WF, Mueller TM, Kinney EL, Tickner EG, Dillon JC, Feigenbaum H. Assessment of myocardial perfusion abnormalities with contrast enhanced two-dimensional echocardiography. Circulation 1982;66:166.PubMedCrossRefGoogle Scholar
  44. 44.
    Kaul S, Pandian NG, Okada Rd, Pohost G, Weyman AE. Contrast echocardiography in acute myocardial ischemia. I. In vivo determination of total left ventricular area at risk. J Am Coll Cardiol 1984;4:1271.CrossRefGoogle Scholar
  45. 45.
    Tei C, Kondo S, Meerbaum S, et al. Correlation of myocardial contrast disappearance rate (“washout”) and severity of experimental coronary stenosis. J Am Coll Cardiol 1984;3:34.PubMedCrossRefGoogle Scholar
  46. 46.
    Sahn DJ, Barratt-Boyes BG, Graham K, et al. Ultrasonic imaging of the coronary arteries in open-chest humans: evaluation of coronary atherosclerotic lesions during cardiac surgery. Circulation 1982;66:1034.PubMedCrossRefGoogle Scholar
  47. 47.
    Funai JT, Pandian NG, Lojeski EW, et al. Study of coronary artery vasomotion by high-frequency two-dimensional echocardiography: effects of nitroglycerin, alpha adrenergic stimulation and beta blockade on coronary artery. Circulation 1984;70:III–184.Google Scholar
  48. 48.
    McPherson D, Armstrong M, Rose E, et al. High frequency epicardial echocardiography for coronary artery evaluation: in vitro and in vivo validation of arterial lumen and wall thickness measurements. J Am Coll Cardiol 1986;8:600.PubMedCrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers. Boston/Dordrecht/Lancaster 1988

Authors and Affiliations

  • Natesa G. Pandian

There are no affiliations available

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