Skip to main content

Left Ventricular Thrombus: Diagnosis, Anticoagulation, and Systemic Embolization

  • Chapter
Echocardiography in Coronary Artery Disease

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 80))

  • 37 Accesses

Abstract

Within the past decade, it has been established that echocardiography can diagnose left ventricular thrombi with a fair degree of accuracy [1–11]. This has been an impetus to the performance of many studies on the natural history of these thrombi and their response to therapy. Unfortunately, the literature occasionally fails to differentiate between clinically different subgroups of patients. Left atrial and left ventricular thrombi are seen in different settings, and echocardiography is better in diagnosing ventricular than atrial thrombi. Three distinct clinical entities associated with the occurrence of left ventricular thrombi should be differentiated: acute myocardial infarction, chronic left ventricular aneurysm as a sequel to myocardial infarction, and idiopathic dilated cardiomyopathy in the absence of coronary disease. We review the accuracy of echocardiography for diagnosing intracardiac thrombi, and then discuss the role of echocardiography in the setting of acute myocardial infarction and chronic aneurysm in detecting thrombi, in predicting embolization, and in decisions about antithrombotic therapy.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Van den Bos AA, Vletter WB, Hagemeijer F. Progressive development of a left ventricular thrombus. Chest 1978;71:417.

    Google Scholar 

  2. Ports TA, Cogan J, Schiller NB, Rapaport E. Echocardiography of left ventricular masses. Circulation 1978;58:528.

    PubMed  CAS  Google Scholar 

  3. DeMaria AN, Bommer W, Neumann A, Grehl T, Weinert L, DeNardo S, Amsterdam EA, Mason DT. Left ventricular thrombi identified by cross-sectional echocardiography. Ann Intern Med 1979;90:14.

    PubMed  CAS  Google Scholar 

  4. Meltzer RS, Guthaner D, Rakowski H, Popp RL, Martin RP. Diagnosis of left ventricular thrombi by two-dimensional echocardiography. Br Heart J 1979;42:261.

    Article  PubMed  CAS  Google Scholar 

  5. Come PC, Markis JE, Vine HS, Sacks B, McArdle C, Ramirez A. Echocardiographic diagnosis of left ventricular thrombi. Am Heart J 1980;100:523.

    Article  PubMed  CAS  Google Scholar 

  6. Asinger RW, Mikell FL, Sharma B, Hodges M. Observations on detecting left ventricular thrombus with two-dimensional echocardiography: emphasis on avoidance of false positive diagnosis. Am J Cardiol 1981;47:145.

    Article  PubMed  CAS  Google Scholar 

  7. Reeder GS, Tajik AJ, Seward JB. Left ventricular mural thrombus: two-dimensional echocardiographic diagnosis. Mayo Clin Proc 1981;56:82.

    PubMed  CAS  Google Scholar 

  8. Takagi Y, Okumachi F, Yoshida K, Kato H, Yanagihara K, Yoshikawa J. Cross-sectional echocardiographic features of mobile left ventricular thrombi. J Cardiogr 1981;11:957.

    PubMed  CAS  Google Scholar 

  9. Van Meurs-Van Woezik H, Meltzer RS, Van den Brand M, Essed CE, Michels RHM, Roelandt J. Superiority of echocardiography over angiocardiography in diagnosing a left ventricular thrombus. Chest 1981;80:321.

    Article  PubMed  Google Scholar 

  10. Stratton J, Lightly G Jr, Pearlman A, Ritchie J. Detection of left ventricular thrombus by two dimensional echocardiography: sensitivity, specificity and causes of uncertainty. Circulation 1982;66:156.

    Article  PubMed  CAS  Google Scholar 

  11. Visser CA, Kan G, David GK, Lie KI, Durrer D. Two-dimensional echocardiography in the diagnosis of left ventricular thrombus: a prospective study of 67 patients with anatomic validation. Chest 1983;83:228.

    Article  PubMed  CAS  Google Scholar 

  12. Levisman JA, MacAlpin RN, Abbasi AS, Ellis N, Eber LM. Echocardiographic diagnosis of a mobile, pedunculated tumor in the left ventricular cavity. Am J Cardiol 1975;36:957.

    Article  PubMed  CAS  Google Scholar 

  13. Horgan JH, O’M Shiel F, Goodman AC. Demonstration of left ventricular thrombus by conventional echocardiography. J Clin Ultrasound 1976;4:287.

    Article  PubMed  CAS  Google Scholar 

  14. De Joseph RL, Shiroff RA, Levenson LW, Martin E, Zelis RF. Echocardiographic diagnosis of intraventricular clot. Chest 1977;71:417.

    Article  Google Scholar 

  15. Green SE, Joynt LE, Fitzgerald PJ, Rubenson DS, Popp RL. In vivo ultrasonic tissue characterization of human intracardiac masses. Am J Cardiol 1983;51:231.

    Article  PubMed  CAS  Google Scholar 

  16. Linzer M, Norton SJ. Ultrasonic tissue characterization. Annu Rev Biophys Bioeng 1982;11:303.

    Article  PubMed  CAS  Google Scholar 

  17. Bean WB. Infarction of the heart. III. Clinical course and morphological findings. Ann Intern Med 1938;12:71.

    Google Scholar 

  18. Hellerstein HK, Martin JW. Incidence of thromboembolic lesions accompanying myocardial infarction. Am Heart J 1946;32:443.

    Article  Google Scholar 

  19. Jordan RA, Miller D, Edwards JE, Parker RL. Thrombo-embolism in acute and healed myocardial infarction. I. Intracardiac mural thrombosis. Circulation 1952;6:1.

    PubMed  CAS  Google Scholar 

  20. Working party on anticoagulant therapy in coronary thrombosis to the Medical Research Council. Assessment of short-term anticoagulant administration after cardiac infarction. Br Med J 1969;1:335.

    Article  Google Scholar 

  21. V.A. Cooperative Clinical Trial Group. Anticoagulants in acute myocardial infarction: results of a cooperative clinical trial. JAMA 1973;225:724.

    Article  Google Scholar 

  22. Asinger RW, Mikell FL, Elsperger J, Hodges M. Incidence of left ventricular thrombosis after acute transmural myocardial infarction: serial evaluation by two-dimensional echocardiography. N Engl J Med 1981;305:297.

    Article  PubMed  CAS  Google Scholar 

  23. Mikell F, Asinger R, Elsperger J, Swenson L, Tilbury T, Hodges M. Long term prospective evaluation of left ventricular thrombus in acute myocardial infarction [abstr]. Circulation 1981;64(suppl IV):IV–93.

    Google Scholar 

  24. Visser CA, Kan G, Lie KI, Durrer D. Left ventricular thrombus following acute myocardial infarction: a prospective serial echocardiographic study of 96 patients. Eur Heart J 1983;4:333.

    PubMed  CAS  Google Scholar 

  25. Visser CA, Kan G, Meltzer RS, Lie KI, Durrer D. Long-term follow up of left ventricular thrombus after acute myocardial infarction: a two-dimensional echocardiographic study in 96 patients. Chest 1984;86:532.

    Article  PubMed  CAS  Google Scholar 

  26. Tramarin R, Pozzoli M, Vecchio C. Trombosi ventricolare sinistra nell’infarto miocardico recente: studio ecocardiografico. G Ital Cardiol 1982;12:397.

    PubMed  CAS  Google Scholar 

  27. Tramarin R, Pozzoli M, Febo O, Opasich C, Cobelli F, Specchia G. Echocardiographic assessment of therapy efficacy in left ventricular thrombosis post myocardial infarction [abstr]. Circulation 1983;68(suppl III):III-331.

    Google Scholar 

  28. McEntee CW, Van Reet RE, Winters WL, Nelson JG, Waggoner AD, Miller RR, Quinones MA. Incidence and natural history of mural thrombi in acute myocardial infarction by two-dimensional echocardiography [abstr]. Circulation 1981;64(suppl IV):IV-93.

    Google Scholar 

  29. Friedman MJ, Carlson K, Marcus FI, Woolfenden JM. Clinical correlations in patients with acute myocardial infarction and left ventricular thrombus detected by two-dimensional echocardiography. Am J Med 1982;72:89.

    Article  Google Scholar 

  30. Keating EC, Gross SA, Schlamowitz RA, Glassman JG, Mazur JH, Pitt WA, Miller D. Mural thrombi in myocardial infarctions: prospective evaluation by two-dimensional echocardiography. Am J Med 1983;74:989.

    Article  PubMed  CAS  Google Scholar 

  31. Kinney EL. The significance of left ventricular thrombi in patients with coronary heart disease: a retrospective analysis of pooled data. Am Heart J 1985;109:191.

    Article  PubMed  CAS  Google Scholar 

  32. Gueret P, Ferrier A, Farcot JC, Dubourg O, Terdjman M, Bardet J, Bourdarias JP. Influence of heparin on left ventricular thrombi formation during the first episode of acute transmural myocardial infarction: a prospective randomized study [abstr]. J Am Coll Cardiol 1984;3:600.

    Google Scholar 

  33. Kothari AJ, Paczkowski K, Baker KM, Schreck SC, Butcher RC, Kline DM, Menapace FM. Ventricular thrombi in acute myocardial infarction: incidence, complications, and effects of anticoagulation [abstr]. J Am Coll Cardiol 1984;3:601.

    Google Scholar 

  34. Eigler N, Maurer G, Shah PK. Early systemic thrombolytic therapy prevents left ventricular mural thrombus formation by acute anterior myocardial infarction [abstr]. J Am Coll Cardiol 1984;3:601.

    Google Scholar 

  35. Weinreich DJ, Burke JF, Pauletto FJ. Serial echocardiographic evaluation of mural thrombi [abstr]. J Am Coll Cardiol 1984;3:614.

    Google Scholar 

  36. Bellotti P, Spirito P, Chiarella F, Domenicucci S, Vecchio C. Early development of left ventricular thrombi in acute anterior myocardial infarction: an index of poor prognosis [abstr]. Circulation 1984;70(suppl II):II-309.

    Google Scholar 

  37. Foale R, Smith G, Nihoyannopoulos P, Maseri A. Left ventricular thrombus in acute myocardial infarction: best left alone? [abstr]. Circulation 1984;70(suppl II):II-310.

    Google Scholar 

  38. Kupper AJF, Verheugt FWA, Den Hollander W, Van der Wall EE, Jaarsma W, Roos JP. Detection of left ventricular thrombosis after recent myocardial infarction in patients receiving oral anticoagulants [abstr]. Circulation 1984;70(suppl II):II-362.

    Google Scholar 

  39. Johannessen KA, Nordrehaug JE, Von der Lippe G. Prevention of left ventricular thrombosis with anticoagulation treatment in acute myocardial infarction [abstr]. Circulation 1984;70(suppl II):II-391.

    Google Scholar 

  40. Liberty SW, Christie LG. Failure of anticoagulation to prevent ventricular thrombus following myocardial infarction [abstr]. Circulation 1984;70(suppl II):II-394.

    Google Scholar 

  41. Cabin HS, Roberts WC. Left ventricular aneurysm, intraaneurysmal thrombus and systemic emolus in coronary heart disease. Chest 1980;77:586.

    Article  PubMed  CAS  Google Scholar 

  42. Lewin RF, Vidne B, Sclarovsky S, Agmon J. Two-dimensional realtime echocardiographic detection of a left ventricular aneurysm associated with mobile pedunculated thrombi. Chest 1980;77:704.

    Article  PubMed  CAS  Google Scholar 

  43. Takagi Y, Okumachi F, Yoshida K, Kato H, Yanagihara K, Yoshikawa J. Cross-sectional echocardiographic features of mobile left ventricular thrombi. J Cardiogr 1981;11:957.

    PubMed  CAS  Google Scholar 

  44. Haugland JM, Asinger RW, Mikell FL, Elsperger J, Hodges M. Embolic potential of left ventricular thrombus detected by two-dimensional echocardiography. Circulation 1984;70:588.

    Article  PubMed  CAS  Google Scholar 

  45. Meltzer RS, Vered Z, Visser C, Roelandt J. Advantages and limitations of echocardiography in detecting potentially embolic intracardiac mass lesions. Pract Cardiol 1982;8:175.

    Google Scholar 

  46. Lew AS, Federman J, Harper RW, Anderson ST, Davis B, Stirling GR, Pitt A. Operative removal of mobile pedunculated left ventricular thrombus detected by 2-dimensional echocardiography. Am J Cardiol 1983;52:1148.

    Article  PubMed  CAS  Google Scholar 

  47. Meltzer RS, Visser CA, Kan G, Roelandt J. Two-dimensional echocardiographic appearance of left ventricular thrombi with systemic emboli after myocardial infarction. Am J Cardiol 1984;53:1511.

    Article  PubMed  CAS  Google Scholar 

  48. Visser CA, Kan G, Meltzer RS, Dunning A, Roelandt J. Embolic potential of left ventricular thrombi after myocardial infarction: a two-dimensional echocardiographic study of 119 patients. J Am Coll Cardiol 1985;5:1276.

    Article  PubMed  CAS  Google Scholar 

  49. Fournal G, Glock Y, Berthoumieu F, Allibelli MJ, Desrez X, Marco J. Thrombus flottant du ventricle gauche après infarctus du myocarde recent traite chirurgicalement. Arch Mal Coeur 1980;73:1415.

    Google Scholar 

  50. Kremer P, Fiebig R, Tilsner V, Bleifeld W, Mathey D. Lysis of left ventricular thrombi with urokinase. Circulation 1985;72:112.

    Article  PubMed  CAS  Google Scholar 

  51. Hochman JS, Platia EB, Bulkley BH. Endocardial abnormalities in left ventricular aneurysms: a clinicopathologic study. Ann Intern Med 1984;100:29.

    PubMed  CAS  Google Scholar 

  52. Hamby RI, Wisoff G, Davison ET, Hartstein ML. Coronary artery disease and left ventricular mural thrombi: clinical, hemodynamic, and angiocardiographic aspects. Chest 1974;66:488.

    Article  PubMed  CAS  Google Scholar 

  53. Simpson MT, Oberman A, Kouchoukos NT, Rogers WJ. Prevalence of mural thrombi and systemic embolization with left ventricular aneurysm: effect of anticoagulation therapy. Chest 1980;77:463.

    Article  PubMed  CAS  Google Scholar 

  54. Reeder GS, Lengyel M, Seward JB, Smith HC, Danielson GK. Mural thrombus in left ventricular aneurysm: incidence, role of angiography, and relation between anticoagulation and embolization. Mayo Clin Proc 1981;56:77.

    PubMed  CAS  Google Scholar 

  55. Lapeyre III AG, Steele PM, Kazmier FJ, Chesbro JH, Vlietstra RE, Fuster V. Systemic embolism in chronic left ventricular aneurysm: incidence and the role of anticoagulation. J Am Coll Cardiol 1985;6:534.

    Article  PubMed  Google Scholar 

  56. Visser CA, Roelandt J. Left ventricular thrombus, Echocardiography 1985;2:245.

    Google Scholar 

  57. Meltzer RS, Visser CA, Fuster V. Intracardiac thrombi and systemic embolization. Ann Int Med 1986;104:689.

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Kluwer Academic Publishers. Boston/Dordrecht/Lancaster

About this chapter

Cite this chapter

Meltzer, R.S., Visser, C.A. (1988). Left Ventricular Thrombus: Diagnosis, Anticoagulation, and Systemic Embolization. In: Visser, C.A., Kan, G., Meltzer, R.S. (eds) Echocardiography in Coronary Artery Disease. Developments in Cardiovascular Medicine, vol 80. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1767-8_14

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-1767-8_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8991-3

  • Online ISBN: 978-1-4613-1767-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics