Cellular Electrophysiology of Electrical Discharges

  • Joseph H. Levine
  • Joseph F. Spear
  • John C. Merillat
  • Harlan F. Weisman
  • Alan H. Kadish
  • E. Neil Moore
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 78)


Myocardial ablation is a new therapeutic option for arrhythmia management. High-energy electrical ablation has been successfully applied to the atrium [1], atrioventricular node [2–6], and accessory pathways [7, 8] for control of automatic and reentrant supraventricular tachycardias. More recently, ventricular ectopic foci have been ablated using high-energy electrical shocks [9–15].


Ventricular Tachycardia Conduction Velocity Catheter Ablation Action Potential Duration Border Zone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Silka MJ, Gillette PC, Garson A, Zinner A: Transvenous catheter ablation of a right atrial automatic ectopic tachycardia. JACC 5: 999, 1985.PubMedGoogle Scholar
  2. 2.
    Beazell J, Tan K, Criley J, Schulman J: The electrosurgical production of heart block without thoracotomy. Clin Res 24: 137A, 1976.Google Scholar
  3. 3.
    Scheinman MM, Morady F, Hess DS, Gonzalez R: Catheter-induced ablation of the atrial-ventricular function to control refractory supraventricular arrhythmias. JAMA 248: 851, 1982.PubMedCrossRefGoogle Scholar
  4. 4.
    Gallagher JJ, Svenson RH, Kasell JH, German LD, Bardy GH, Broughton A, Critelli G: Catheter technique for closed chest ablation of the atrioventricular conduction system: A therapeutic alternative for the treatment of refractory supraventricular tachycardia. N Engl J Med 306: 194, 1984.CrossRefGoogle Scholar
  5. 5.
    Trantham JL, Gallagher JJ, German LD, Broughton A, Guarnieri T, Kassel J: Effects of energy delivery via a His-bundle catheter during closed chest ablation of the atrioventricular conduction system. J Clin Invest 72: 1563, 1983.PubMedCrossRefGoogle Scholar
  6. 6.
    Gonzales R, Scheinman MM, Margaretter W: Closed-chest electrode catheter technique for His-bundle ablation in dogs. Am J Physiol 241: H283, 1981.Google Scholar
  7. 7.
    Morady F, Scheinman MM: Transvenous catheter ablation of a posteroseptal accessory pathway in patient with the Wolff-Parkinson-White Syndrome. N Eng J Med 310: 705, 1984.CrossRefGoogle Scholar
  8. 8.
    Brodman R, Fisher JD: Evaluation of a catheter technique for ablation of accessory pathways near the coronary sinus using a canine model. Circulation 67: 923, 1983.PubMedCrossRefGoogle Scholar
  9. 9.
    Hartzler GO: Electrical catheter ablation of refractory focal ventricular tachycardia. JACC 2: 1107, 1983.PubMedGoogle Scholar
  10. 10.
    Winston SA, Davis JC, Morady F, DiCarlo LA, Matsubara T, Wexman MP, Scheinman MM: A new approach to electrode catheter ablation for ventricular tachycardia arising from the intraventricular septum. Circulation 70(Suppl II): 11–412, 1984.Google Scholar
  11. 11.
    Winston SA, Morady F, Davis JC, Di Carlo LA, Wexman MP, Scheinman MM: Catheter ablation of ventricular tachycardia. Circulation 70(Suppl II): 11–412, 1984.Google Scholar
  12. 12.
    Steinhaus D, Whilford E, Stavens C, Schneller S, McComb J, Carr J, McGovern B, Garan H, Ruskin J: Percutaneous transcatheter electrical ablation for recurrent sustained ventricular tachycardia. Circulation 70(Suppl II): 11–100, 1984.Google Scholar
  13. 13.
    Harztler GO, Giorgi LV: Electrode catheter ablation of refractory ventricular tachycardia. Continued experience (abstract) JACC 3: 512, 1984.Google Scholar
  14. 14.
    Ruffy R, Kim SS, Lal R: Paroxysmal fascicular tachycardia: Electrophysiologic characteristics and treatment by catheter ablation. J Am Coll Cardiol 5: 1008, 1985.PubMedCrossRefGoogle Scholar
  15. 15.
    Belhassen B, Miller HI, Geller E, Laniado S: Transcatheter electrical shock ablation of ventricular tachycardia. JACC 7: 1347, 1986.PubMedGoogle Scholar
  16. 16.
    Lee BI, Gottdiener JS, Fletcher RD, Rodriguez ER, Ferrans VJ: Transcatheter ablation: Comparison between laser photoablation and electrode shock ablation in the dog. Circulation 71: 579, 1985.PubMedCrossRefGoogle Scholar
  17. 17.
    Lerman BB, Weiss JL, Bulkley BH, Becker LC, Weisfeldt ML: Myocardial injury and induction of arrhythmia by direct current shock delivered via endocardial catheters in dogs. Circulation 69: 1006, 1984.PubMedCrossRefGoogle Scholar
  18. 18.
    Westveer DC, Nelson T, Stewart JR, Thornton EP, Gordon S, Timmis GC: Sequelae of left ventricular electrical endocardial ablation, JACC 5: 956, 1985.PubMedGoogle Scholar
  19. 19.
    Kempf FC, Falcone RA, Marchlinski FE, Josephson ME: The electrophysiologic effects of high-energy electrical discharges in the ventricle (abstract) JACC 3(2): 554A.Google Scholar
  20. 20.
    Jones JL, Lepeschkin E, Jones RE, Rush S: Response of cultured myocytes to countershock-type electric field stimulation. Am J Physiol 235: H214, 1978.PubMedGoogle Scholar
  21. 21.
    Jones JL, Jones RE: Decreased defibrillator-induced dysfunction with biphasic rectangular wave forms. Am J Physiol 247: H792, 1984.PubMedGoogle Scholar
  22. 22.
    Jones JL, Jones RE: Improved defibrillator waveform safety factor with biphasic waveforms. Am J Physiol 245: H60, 1983.PubMedGoogle Scholar
  23. 23.
    Bailey JC, Spear JF, Moore EN: Microelectrode demonstration of Wedensky facilitation in canine cardiac Purkinje fibers. Circ Res 33: 48, 1973.PubMedGoogle Scholar
  24. 24.
    Levine JH, Spear JF, Weisman HF, Kadish AH, Prood C, Siu CO, Moore EN: The cellular electrophysiologic changes induced by high-energy electrical ablation in canine myocardium. Circulation 73: 818, 1986.PubMedCrossRefGoogle Scholar
  25. 25.
    Fozzard HA: Conduction of the action potential. In: Handbook of Physiology. RM Berne, N Sperelakis, SR Geiger, eds. Wash DC: Am Physiol Soc, pp 335–392, 1979.Google Scholar
  26. 26.
    Spear JF, Moore EN: Supernormal excitability and conduction in the His-Purkinje system of the dog. Circ Res 35: 782, 1974.PubMedGoogle Scholar
  27. 27.
    Spear JF, Michelson EL, Moore EN: Reduced space constant in slowly conducting regions of chronically infarcted canine myocardium. Circ Res 53: 176, 1983.PubMedGoogle Scholar
  28. 28.
    Friedman R, Moak JP, Garson A: Endocardial catheter ablation of ventricular muscle induces arrhythmias: Reentry, abnormal automaticity and triggered activity (abstract) JACC 7(2): 38A, 1986.Google Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1988

Authors and Affiliations

  • Joseph H. Levine
  • Joseph F. Spear
  • John C. Merillat
  • Harlan F. Weisman
  • Alan H. Kadish
  • E. Neil Moore

There are no affiliations available

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