Abstract
For a number of years the estimation of gene product (Factor VIII) concentrations was used for genotype assignment in potential carriers as well as in prenatal diagnosis of hemophilia A. The difficulty with this method for carrier testing is the probabilistic nature of the result. The Factor VIII assay is converted into a likelihood ratio favouring carriership and this ratio is combined with the genetic chance to yield a final probability of carriership [1–3]. In practice, however, it is very difficult for the women to base their decisions on this kind of information.
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© 1988 Kluwer Academic Publishers, Boston
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Briët, E., Bröcker-Vriends, A.H.J.T. (1988). Use of Gene Probes for Carrier Detection and Prenatal Diagnosis in Hemophilia A. In: Sibinga, C.T.S., Das, P.C., Overby, L.R. (eds) Biotechnology in blood transfusion. Developments in Hematology and Immunology, vol 21. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1761-6_18
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DOI: https://doi.org/10.1007/978-1-4613-1761-6_18
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