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Production and Application of Monoclonal Antibodies in T-Cell Depletion of Bone Marrow for Transplantation

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Biotechnology in blood transfusion

Part of the book series: Developments in Hematology and Immunology ((DIHI,volume 21))

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Abstract

Recent biotechnological developments have provided an increasingly precise and specific discrimination of cells according to their cell surface marker phenotype [1]. Production and purification techniques of monoclonal antibodies (MoAbs) have become standardized today. Their clinical application (systemic infusion, ex-vivo purging) requires purification conditions and control methods which provide the clinician with a perfectly controlled product which is compatible with its therapeutic use. At present, we have a wide panel of MoAbs specific to T-cells at various differentation levels which provide experimental and clinical investigations so that normal marrow T-cells (GvHD prevention) or leukemia T-cells (minimum residual disease purging) can be removed from the marrow.

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Authors
  1. P. Hervé
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Editors and Affiliations

  1. Red Cross Blood Bank Groningen-Drenthe, The Netherlands

    C. Th. Smit Sibinga  & P. C. Das  & 

  2. Chiron Corporation, Emmeryville, California, USA

    L. R. Overby

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© 1988 Kluwer Academic Publishers, Boston

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Hervé, P. (1988). Production and Application of Monoclonal Antibodies in T-Cell Depletion of Bone Marrow for Transplantation. In: Sibinga, C.T.S., Das, P.C., Overby, L.R. (eds) Biotechnology in blood transfusion. Developments in Hematology and Immunology, vol 21. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1761-6_15

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  • DOI: https://doi.org/10.1007/978-1-4613-1761-6_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8988-3

  • Online ISBN: 978-1-4613-1761-6

  • eBook Packages: Springer Book Archive

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