Quality Control of Vaccines

  • Denise H. Thornton
Part of the Developments in Veterinary Virology book series (DVVI, volume 8)


Adequate quality control of vaccines is essential to avoid economic losses due to the application of unsafe or ineffective products and to ensure the health and welfare of the recipients of the vaccines. It is particularly important in the poultry industry where there is a large population with a rapid turnover and vaccines are in almost universal use: an ineffective product may lead to widespread outbreaks of disease; a contaminated product can introduce new disease to the poultry industry which may take many years to eradicate or control.


Vaccine Strain Newcastle Disease Allantoic Fluid Specific Pathogen Free Potency Test 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Hanson, R.P. Dev. Biol. Stand. 25: 179–187, 1974.Google Scholar
  2. 2.
    Spalatin, J. and Hanson, R.P. Avian Dis. 20: 654–660, 1976.PubMedCrossRefGoogle Scholar
  3. 3.
    Borland, L.J. and Allan, W.H. Avian Pathol. 9: 45–59, 1980.PubMedCrossRefGoogle Scholar
  4. 4.
    Shortridge, K.F., Allan, W.H. and Alexander, D.J. Newcastle disease: laboratory diagnosis and vaccine evaluation. Hong Kong University Press, 1982.Google Scholar
  5. 5.
    Lensing H.H. Dev. Biol. Stand. 25: 189–194, 1974.Google Scholar
  6. 6.
    National Research Council Subcommittee on Avian Diseases. Methods for Examining Poultry Biologics and for Identifying and Quantifying Avian Pathogens. National Academy of Sciences, Washington DC, 1971.Google Scholar
  7. 7.
    Hanson, R.P. In: Isolation and identification of avian pathogens, 2nd Ed. eds S.B. Hitchner, C.H. Domermuth, H.G. Purchase and J.E. Williams. American Association of Avian Pathologists, Texas A and M University, 1980, pp. 63–66.Google Scholar
  8. 8.
    Nagy, E. and Lomniczi, B. J. Virol. Methods 9: 227–235, 1984.CrossRefGoogle Scholar
  9. 9.
    McMillan, B.C. and Hanson, R.P. Avian Dis. 24: 1016–1020, 1980.PubMedCrossRefGoogle Scholar
  10. 10.
    Russell, P.H. and Alexander, D.J. Arch. Virol. 75: 243–253, 1983.PubMedCrossRefGoogle Scholar
  11. 11.
    Meulemans, G., Gonze, M., Carlier, M.C., Petit, P., Burny, A. and Long, L. Arch. Virol. 92: 55–62, 1987.PubMedCrossRefGoogle Scholar
  12. 12.
    Beard, C.W. and Hanson, R.P. In: Diseases of Poultry, 8th ed., eds M.S. Hofstad, H.J. Barnes, B.W. Calnek, W.M. Reid and H.W. Yoder. Iowa State University Press, Ames, 1984 pp. 452–470.Google Scholar
  13. 13.
    Rott, R. Arch. Virol. 59: 285–298, 1979.PubMedCrossRefGoogle Scholar
  14. 14.
    Samson, A.C.R., Russell, P.H. and Hallam, S.E. J. Gen. Virol. 66: 357–361, 1985.PubMedCrossRefGoogle Scholar
  15. 15.
    Allan, W.H. and Borland, L.J. Avian Pathol. 8: 401–409, 1979.PubMedCrossRefGoogle Scholar
  16. 16.
    Bancroft, B.J. and Spradbrow, P.B. Aust. Vet. J. 54: 500–501, 1978.PubMedCrossRefGoogle Scholar
  17. 17.
    Borland, L.J. and Allan, W.H. Avian Pathol. 9: 261–269, 1980.PubMedCrossRefGoogle Scholar
  18. 18.
    Kaleta, E.F., Siegmann, O., Jank-Ladwig, R. and Glunder, G. Comp. Immunol. Microbiol. Infect. Dis. 2: 485–496, 1980.CrossRefGoogle Scholar
  19. 19.
    Thornton, D.H. and Hebert, C.N. J. Biol. Stand. 8: 127–132, 1980.PubMedCrossRefGoogle Scholar
  20. 20.
    Thornton, D.H., Hopkins, I.G. and Hebert, C.N. Avian Pathol. 9: 457–464, 1980.PubMedCrossRefGoogle Scholar
  21. 21.
    Thornton, D.H. and Muskett, J.C. Vet. Rec. 96: 467–468, 1975.PubMedCrossRefGoogle Scholar
  22. 22.
    Allan, W.H. and Thornton, D.H. J. Biol. Stand. 8: 133–138, 1980.PubMedCrossRefGoogle Scholar
  23. 23.
    United States Department of Agriculture. Code of Federal Regulations Section 9, 1976, USDA, Washington DC.Google Scholar
  24. 24.
    Ministry of Agriculture, Fisheries and Food. Specifications for the production and control of avian live virus vaccines, 2nd ed. Central Veterinary Laboratory, Weybridge, 1977.Google Scholar
  25. 25.
    Allan W.H., Lancaster, J.B. and Toth B. The production and use of Newcastle disease vaccines. FAO, Rome, 1973.Google Scholar
  26. 26.
    Allan, W.H. and Hebert, C.N. Arch. Gesamte. Virusforsch. 25: 330–336, 1968.PubMedCrossRefGoogle Scholar
  27. 27.
    Thornton, D.H., Wood, G.W. and Hebert, C.N. J. Biol. Stand. 12: 131–136, 1984.PubMedCrossRefGoogle Scholar
  28. 28.
    Wood, G.W., Hebert, C.N. and Thornton, D.H. J. Biol. Stand. 8: 157–163, 1980.PubMedCrossRefGoogle Scholar
  29. 29.
    Frerichs, G.N. and Chandler, M.D. J. Biol. Stand. 10: 205–211, 1982.PubMedCrossRefGoogle Scholar
  30. 30.
    Perrin, G.G. and Perrin, G.J. Rev. Med. Vet. 129: 281–284, 1978.Google Scholar
  31. 31.
    Vindevogel, H. and Duchatel, J.P. Ann. Med. Vet. 129: 471–473, 1985.Google Scholar
  32. 32.
    Wallis, A.S. Vet. Rec. 114: 51–52, 1984.PubMedCrossRefGoogle Scholar
  33. 33.
    Stones, P.B. Br. Med. J. 1: 1627, 1979.PubMedCrossRefGoogle Scholar
  34. 34.
    Anon. Br. Med. J. 294: 652, 1987.Google Scholar
  35. 35.
    Warden, D., Furminger, I.G.S. and Robertson, W.W. Vet. Rec. 96: 65–66, 1975.PubMedCrossRefGoogle Scholar
  36. 36.
    British Pharmacopoeia (Veterinary) 1985, HMSO, London, 1985.Google Scholar
  37. 37.
    Thornton, D.H. Unpublished observations.Google Scholar
  38. 38.
    Hyde R.L.W. Dev. Biol. Stand. 64: 149–151, 1986.PubMedGoogle Scholar
  39. 39.
    Stone, H.D. Avian Dis. 29: 721–728, 1985.PubMedCrossRefGoogle Scholar
  40. 40.
    Stone, H.D., Brugh, M. and Beard, C.W. Avian Dis. 27: 688–697, 1983.PubMedCrossRefGoogle Scholar
  41. 41.
    Piedrafita, J.G. 9th Wlds. Poult. Cong. Paris, 3: 146–148, 1951.Google Scholar
  42. 42.
    Nicholas, R.A.J. and Thornton, D.H. Vet. Bull. 56: 337–343, 1986.Google Scholar
  43. 43.
    Chandler, M.D. and Frerichs, G.N. J. Biol. Stand. 10: 169–170, 1982.PubMedCrossRefGoogle Scholar
  44. 44.
    Council of Europe. European Pharmacopoeia, 2nd Ed. Maisonneuve SA, Sainte-Ruffine, 1980.Google Scholar
  45. 45.
    Nicholas, R.A.J., Wood, G.W. and Thornton, D.H. J. Biol. Stand. 11: 75–81, 1983.PubMedCrossRefGoogle Scholar
  46. 46.
    Nicholas, R.A.J., Wood, G.W., Hopkins, I.G. and Thornton, D.H. Res. Vet. Sci. 40: 118–122, 1986.PubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1988

Authors and Affiliations

  • Denise H. Thornton
    • 1
  1. 1.Central Veterinary LaboratoryWeybridge, SurreyEngland

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