Abstract
During the last century, there have been many reports concerning the clinical application of hyperthermia in the treatment of human cancers [1–4]. The positive responses observed, although unpredictable and often evanescent, stimulated investigators to understand the action mechanism of heat better in order to apply hyperthermia rationally in the clinical setting. Not until the 1960s did in vitro and in vivo experiments demonstrate the selective heat sensitivity of cancer cells, and the first clinical applications of hyperthermic perfusion confirmed the effectiveness of heat in treating cancer [5].
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Di Filippo, F. et al. (1989). Thermochemotherapy for soft tissue sarcoma. In: Pinedo, H.M., Verweij, J. (eds) Treatment of Soft Tissue Sarcomas. Cancer Treatment and Research, vol 44. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1757-9_9
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DOI: https://doi.org/10.1007/978-1-4613-1757-9_9
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