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Thermochemotherapy for soft tissue sarcoma

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Treatment of Soft Tissue Sarcomas

Abstract

During the last century, there have been many reports concerning the clinical application of hyperthermia in the treatment of human cancers [1–4]. The positive responses observed, although unpredictable and often evanescent, stimulated investigators to understand the action mechanism of heat better in order to apply hyperthermia rationally in the clinical setting. Not until the 1960s did in vitro and in vivo experiments demonstrate the selective heat sensitivity of cancer cells, and the first clinical applications of hyperthermic perfusion confirmed the effectiveness of heat in treating cancer [5].

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References

  1. Busch W: Uber den Einfluss welchen heftiger erysipeln zuweilen auf organisierte Neubildungen ausuben. Verhandlungen des Naturhistorischer. Vereins Preussicher Rheinlands Westphalen 23:28–30, 1866.

    Google Scholar 

  2. Coley WB: The treatment of malignant tumours by repeated inoculations of erysipelas with a report of original cases. Am J Med Sci 105:487–511, 1893.

    Article  Google Scholar 

  3. Rohdenburg GL, et al.: The effect of combined radiation and heat on neoplasms. Arch Surg 2:1548–1554, 1906.

    Google Scholar 

  4. Warren SL: Preliminary study of the effect of artificial fever upon hopeless tumour cases. AJR 33:75–87, 1935.

    Google Scholar 

  5. Cavaliere R, et al.: Selective heat sensitivity of cancer cells: biochemical and clinical studies. Cancer 20:1351–1381, 1967.

    Article  PubMed  CAS  Google Scholar 

  6. Hunt JW: Applications of microwave, ultrasounds and radiofrequencies heating in vivo. In: Dethlefsen LA, Dewey WC (eds) Proceedings of the third international symposium on cancer therapy by hyperthermia, drugs and radiation. Bethesda MD; 447–456, 1984.

    Google Scholar 

  7. Gerner EW: Thermotolerance. In: Hyperthermia in cancer therapy, FK Storm, Boston: GK Hall, 1983, pp 141–162.

    Google Scholar 

  8. Dewey WC: Interaction of heat with radiation and chemotherapy. Cancer Res [Suppl] 44: 4714, 1984.

    Google Scholar 

  9. Gillette EG: Clinical use of thermal enhancement and therapeutic gain for hyperthermia combined with radiation or drugs. Cancer Res [Suppl] 44:4836, 1984.

    Google Scholar 

  10. Field SB, et al.: Thermotolerance: a review of observations and possible mechanism. Natl Cancer Inst Monogr 61:193–201, 1982.

    PubMed  CAS  Google Scholar 

  11. Nielsen OS, et al.: Arrhenius analysis of survival curves from thermotolerant and step-down heated L1A2 cells in vitro. Radiat Res 91:468–482, 1982.

    Article  PubMed  CAS  Google Scholar 

  12. Hahn GM: Hyperthermia and cancer. New York: Plenum, 1982, pp 74–85.

    Google Scholar 

  13. Hahn GM, et al.: Thermochemotherapy: synergism between hyperthermia (42–43) and adriamycin (or bleomycin) in mammalian cell inactivation. Proc Natl Acad Sci USA 72: 937–940, 1975.

    Article  PubMed  CAS  Google Scholar 

  14. Hahn GM: Potential for therapy of drugs and hyperthermia. Cancer Res 39:2264–2268, 1979.

    PubMed  CAS  Google Scholar 

  15. Marmor JE: Interactions of hyperthermia and chemotherapy in animals. Cancer Res 39: 2269–2276, 1979.

    PubMed  CAS  Google Scholar 

  16. Greco C, et al.: Effect of sequential application of hyperthermia and chemotherapy on the survival of a thermoresistant human melanoma cell line. Cancer Biochem Biophys 9:223–232, 1987.

    PubMed  CAS  Google Scholar 

  17. Moricca G, et al.: Hyperthermic treatment of tumors: experimental and clinical applications. Recent Results Cancer Res 59:112–151, 1977.

    PubMed  Google Scholar 

  18. Bull JMC: An update of the anticancer effects of a combination of chemotherapy and hyperthermia. Cancer Res [Suppl] 44:4853–4856, 1984.

    Google Scholar 

  19. Schraffordt Koops HS, et al.: Isolated regional perfusion in the treatment of soft tissue sarcomas of the extremities. Clin Oncol 2:245–252, 1976.

    Google Scholar 

  20. Karakousis CP, et al.: Touniquet infusion versus hyperthermic perfusion. Cancer 49:850–858, 1982.

    Article  PubMed  CAS  Google Scholar 

  21. Lehti PM, et al.: Improved survival for soft tissue sarcoma of the extremities by regional hyperthermic perfusion, local excision and radiation therapy. Surg Gynecol Obstet 162: 149–152, 1986.

    PubMed  CAS  Google Scholar 

  22. Stehlin JS, et al.: 15 year’s experience with hyperthermic perfusion for treatment of soft tissue sarcoma and malignant melanoma of the extremities. In: Vaeth JM (ed) Hyperthermia and radiation therapy/chemotherapy in the treatment of cancer. San Francisco, 1984, pp 177–182.

    Google Scholar 

  23. Jabboury K, et al.: Local hyperthermia for resistant soft tissue sarcoma [abstr]. In: 34th annual meeting of the Radiation Research Society, Las Vegas, April 1986, p 18.

    Google Scholar 

  24. Bicher HI, et al.: Clinical thermoradiotherapy. In: Storm FK (ed) Hyperthermia in cancer therapy. Boston: GK Hall, 1983.

    Google Scholar 

  25. Storm FK, et al.: Magnetic induction hyperthermia: results of a 5 year multiinstitutional national cooperative trial in advanced cancer patients. Cancer 55:2677–2687, 1985.

    Article  PubMed  CAS  Google Scholar 

  26. Di Filippo F, et al.: Role of hyperthermic perfusion as a first step in the treatment of soft tissue sarcoma of the extremities. World J Surg 12:332–339, 1988.

    Article  PubMed  Google Scholar 

  27. Bull JMC, et al.: An update of whole body hyperthermia + BCNU in advanced sarcoma [abstr]. Proc Am Soc Clin Oncol 5:144, 1986.

    Google Scholar 

  28. Gerad H, et al.: Doxorubicun, cyclophosphamide and W.B.H. for treatment of advanced soft tissue sarcomas. Cancer 53:2585–2591, 1984.

    Article  PubMed  CAS  Google Scholar 

  29. Herman TS, et al.: W.B.H. and chemotherapy for treatment of patients with advanced refractory malignancies. Cancer Treat Rep 66:259–265, 1982.

    PubMed  CAS  Google Scholar 

  30. Har-Kedar I, et al.: Experimental and clinical aspects of hyperthermia applied to the treatment of cancer with special reference to the role of ultrasonic and microwave heating. Adv Radiat Biol 6:229–266, 1976.

    Google Scholar 

  31. Hahn GM: Interactions of drugs and hyperthermia in vitro and in vivo. In: Streffer C (ed) Proceedings of the second international symposium on cancer therapy by hyperthermia and radiation. Baltimore: Urban and Schwarzenberg, 1978, pp 72–79.

    Google Scholar 

  32. Song CW: Effect of local hyperthermia on blood flow and microenvironment: a review. Cancer Res [Suppl] 44:4721–4730, 1984.

    Google Scholar 

  33. Emami B, et al.: Histopathological study on the effects of hyperthermia on microvasculature. Int J Radiat Oncol Biol Phys 7:343–348, 1981.

    Article  PubMed  CAS  Google Scholar 

  34. Olch A, et al.: Blood flow in human tumors during hyperthermic therapy: demonstration of vasoregulation and an applicable physiological model. J Surg Oncol 23:125–132, 1983.

    Article  PubMed  CAS  Google Scholar 

  35. Li GC, et al.: Correlation between synthesis of heat shock proteins and development of thermotolerance in Chinese hamster fibroblasts. Proc Natl Acad Sci USA 79:3219–3222, 1982.

    Google Scholar 

  36. Tomasovic SP, et al.: Heat stress proteins and thermal resistance in rat mammary tumor cells. Radiat Res 70:610–611, 1977.

    Google Scholar 

  37. Reinhold HS, et al.: Enhancement of thermal damage to sandwich tumors by additional treatment. In: Arcangeli G, Mauro F (eds) Proceedings of the first meeting of the European Group on Hyperthermia in Radiation Oncology. Milan: Massom, 1980, pp 179–183.

    Google Scholar 

  38. Kim JH, et al.: Lonidamine: a hyperthermic sensitizer of HeLa cells in culture and of Meth-A tumor in vivo. Oncology [Suppl 1] 41:30–35, 1984.

    Article  PubMed  CAS  Google Scholar 

  39. Kim JH, et al.: Quercetin, an inhibitor of lactate transport and a hyperthermic sensitizer of HeLa cells. Cancer Res 44:102–106, 1984.

    PubMed  CAS  Google Scholar 

  40. Barlogie B, et al.: In vitro thermochemotherapy of human colon cancer cells with CDDP and mitomycin C. Cancer Res 40:1165–1168, 1980.

    PubMed  CAS  Google Scholar 

  41. Herman TS: Effect of temperature on the cytotoxicity of vindesine, amsacrine and mito-xantrone. Cancer Treat Rep 67:1019–1022, 1983.

    PubMed  CAS  Google Scholar 

  42. Johnson HA, et al.: Thermal enhancement of thiotepa cytotoxicity. J Natl Cancer Inst 50: 903–908, 1973.

    PubMed  CAS  Google Scholar 

  43. Joiner MC, et al.: Response of two mouse tumors to hyperthermia with CCNU or mel-phalan. Br J Cancer 45:19–26, 1982.

    Article  Google Scholar 

  44. Lees DE, et al.: Internal organ hypoxia during hyperthermic cancer therapy in humans. In: Proceedings of the third international symposium on cancer therapy by hyperthermic drugs and radiation, Fort Collins CO, 1980, p 93.

    Google Scholar 

  45. Meyn RE, et al.: Thermal enhancement of DNA damage in mammalian cells treated with CDDP. Cancer Res 40:1136–1139, 1980.

    PubMed  CAS  Google Scholar 

  46. Bleehan NM, et al.: Interaction of hyperthermia and the hypoxic cell sensitizer RO-07–0582 on the EMT6 mouse tumor. Br J Cancer 35:299–306, 1977.

    Article  Google Scholar 

  47. Kapp DS, et al.: Thermosensitization by sulfhydryl compounds of exponentially growing Chinese hamster cells. Cancer Res 29:4630–4635, 1979.

    Google Scholar 

  48. Robins IH, et al.: Systemic lidocaine enhancement of hyperthermia-induced tumor regression in transplantable murine tumor models. Cancer Res 43:3187–3191, 1983.

    PubMed  CAS  Google Scholar 

  49. Herman TS, et al.: Reversal of resistance to methotrexate by hyperthermia in Chinese hamster ovary cells. Cancer Res 41:3840–3843, 1981.

    PubMed  CAS  Google Scholar 

  50. Mimnaugh EG, et al.: Effect of W.B.H. on the deposition and metabolism of ADR in rabbits. Cancer Res 38:1420–1425, 1978.

    PubMed  CAS  Google Scholar 

  51. Cavalière R, et al.: Regional perfusion hyperthermia. In: Storm FK (ed) Hyperthermia in cancer therapy. Boston: GK Hall, 1983.

    Google Scholar 

  52. Cheung AY, et al.: Deep local hyperthermia for cancer therapy: external electromagnetic and ultrasound techniques. Cancer Res [Suppl] 44:4736–4744, 1984.

    Google Scholar 

  53. Atkinson ER: Hyperthermia techniques and instrumentation. In: Storm FK (ed) Hyperthermia in cancer therapy. Boston: GK Hall, 1983, pp 233–255.

    Google Scholar 

  54. Milligan AJ: Whole body hyperthermia induction techniques. Cancer Res [Suppl] 44: 4869–4872, 1984.

    Google Scholar 

  55. Barlogie B, et al.: Total body hyperthermia with and without chemotherapy for advanced human neoplasms. Cancer Res 39:1481–1489, 1979.

    PubMed  CAS  Google Scholar 

  56. Bull JM, et al.: Whole body hyperthermia: now a feasible addition to cancer treatment. Proc Am Assoc Cancer Res 19:405, 1978.

    Google Scholar 

  57. Larkin JM, et al.: Systemic thermotherapy: description of a method and physiologic tolerance in clinical subjects. Cancer 40:3155–3159, 1977.

    Article  PubMed  CAS  Google Scholar 

  58. Parks LC, et al.: Treatment of far advanced bronchogenic carcinoma by extracorporeally induced systemic hyperthermia. J Thorac Cardiovasc Surg 28:467–477, 1979.

    Google Scholar 

  59. Pettigrew RT, et al.: Whole body hyperthermia combined with chemotherapy in the treatment of advanced human cancer. In: Streffer C (ed) Cancer therapy by hyperthermia and radiation. Baltimore: Urban and Schwarzenberg, 1978, pp 326–327.

    Google Scholar 

  60. Di Filippo F, et al.: Isolated hyperthermic perfusion with CDDP in the treatment of limb tumors: phase I study—toxicity and pharmacokinetics. J Exp Clin Cancer Res 6:257–265, 1987.

    Google Scholar 

  61. Russel WO, et al.: A clinical and pathological staging system for soft tissue sarcomas. Cancer 40:1562–1570, 1977.

    Article  Google Scholar 

  62. Berkson J, Gage RP: Calculation of survival rates for cancer. Mayo Clin Proc 25:270–286, 1950.

    CAS  Google Scholar 

  63. Cantin J, et al.: The problem of local recurrences after treatment of soft tissue sarcoma. Ann Surg 168:47–53, 1968.

    Article  PubMed  CAS  Google Scholar 

  64. Heise HW, et al.: Recurrence-free survival time for surgically treated soft tissue sarcoma patients: multivariate analysis of five prognostic factors. Cancer 57:172–177, 1986.

    Article  PubMed  CAS  Google Scholar 

  65. Cruz AB, et al.: Combination chemotherapy for soft tissue sarcomas: a phase II study. J Surg Oncol 11:313–323, 1979.

    Article  PubMed  Google Scholar 

  66. Greenall MS, et al.: Chemotherapy for soft tissue sarcoma. Surg Gynecol Obstet 162: 193–198, 1986.

    PubMed  CAS  Google Scholar 

  67. Verweij J, Pinedo HM: Chemotherapy in advanced soft tissue sarcoma In: Pinedo HM, Verweij J (eds) Clinical management of soft tissue sarcoma. Boston: Martinus Nijhoff, 1986, pp 81–88.

    Chapter  Google Scholar 

  68. Eilber FR, et al.: Limb salvage for skeletal and soft tissue sarcomas: multidisciplinary preoperative therapy. Cancer 53:2579–2584, 1984.

    Article  PubMed  CAS  Google Scholar 

  69. Rosenberg SA, et al.: Sarcomas of the soft tissue and bone. In: Devita, Hellman, Rosenberg (eds) Cancer: principles and practice of oncology. Philadelphia: JB Lippincott, 1982, pp 1036–1093.

    Google Scholar 

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© 1989 Kluwer Academic Publishers, Boston

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Di Filippo, F. et al. (1989). Thermochemotherapy for soft tissue sarcoma. In: Pinedo, H.M., Verweij, J. (eds) Treatment of Soft Tissue Sarcomas. Cancer Treatment and Research, vol 44. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1757-9_9

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  • DOI: https://doi.org/10.1007/978-1-4613-1757-9_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8986-9

  • Online ISBN: 978-1-4613-1757-9

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