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Chemotherapy in advanced soft tissue sarcomas

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Treatment of Soft Tissue Sarcomas

Part of the book series: Cancer Treatment and Research ((CTAR,volume 44))

Abstract

With local recurrence rates of 40%–80% [1] and most of these relapses occurring within 3 years [2], soft tissue sarcomas have always been a difficult tumor type for adequate local treatment. Although sophisticated surgical techniques and the addition of postoperative high-dose radiotherapy have considerably reduced the number of local recurrences in extremity lesions [2–5], the inability to apply the necessary high doses of irradiation precluded a decrease in local recurrence in truncal lesions by using the combination of surgery and radiotherapy. Besides, soft tissue sarcomas metastasize by (apparently early) hematogeneous spreading, most frequently to the lungs, which can only partly be prevented by optimal local control of the primary tumor. Therefore, distant metastases still occur in a considerable number of patients, for whom systemic treatment with chemotherapy will be considered.

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Authors
  1. Jaap Verweij
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  2. Cees J. van Groeningen
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  3. Herbert M. Pinedo
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Editors and Affiliations

  1. Department of Medical Oncology, Free University Hospital, Amsterdam, The Netherlands

    Herbert M. Pinedo

  2. Department of Medical Oncology, Rotterdam Cancer Institute, Rotterdam, The Netherlands

    Jaap Verweij

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© 1989 Kluwer Academic Publishers, Boston

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Verweij, J., van Groeningen, C.J., Pinedo, H.M. (1989). Chemotherapy in advanced soft tissue sarcomas. In: Pinedo, H.M., Verweij, J. (eds) Treatment of Soft Tissue Sarcomas. Cancer Treatment and Research, vol 44. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1757-9_6

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