Abstract
Specific interactions between cells and the extracellular matrix (ECM) with which they are in contact play a vital role in tissue organization (1,2). Such interactions are important for directed migration of embryonic cells during development (1,3,4), and for tissue induction during morphogenesis (3,4). It has been established in many model systems, of which the mammary gland is a prime example, that ECM components can support induction and maintenance of tissue-specific function in epithelial cells placed in culture (5,6,7). One important feature of this induction is the modulation of cell shape by interaction with ECM components (5,6,8). In addition to its effects in regulating cell shape and differentiated gene expression, the ECM also exerts an important influence on cell growth and division (10). In transformed cells, progressive loss of differentiated function, altered morphology, and unchecked growth reflect loss of the ability to respond to the external signals that control these functions in normal cells (11).
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References
Wessells, N.K. Tissue Interactions and Development, Benjamin/ Cummings, Calif., 1977.
Hay, E.D. Mod. Cell. Biol. 2: 509–548, 1983.
Adamson, E.D. In: Collagen in Health and Disease (Eds. J.B. Weiss and M.I.V. Jayson), Churchill Livingstone, Edinburgh, 1982, pp. 218–243.
Tucker, R.P. and Erickson, C.A. Dev. Biol. 104: 390–405, 1984.
Emerman, J.T. and Pitelka, D.R. In Vitro 13:316–327, 1977.
Bissell, M.J., Hall, H.G. and Parry, G. J. Theoret. Biol. 99:31–68, 1982.
Lee, E.Y.-H., Parry, G. and Bissell, M.J. J. Cell Biol. 98:146–155, 1984.
Kleinman, H.K., McGarvey, M.L., Hassell, J.R., Star, C.L., Cannon, F.B., Laurie, G.W. and Martin, G.R. Biochemistry 25:312–318, 1986.
Watt, F. Trends Biochem. Sci. 11: 482–485, 1986.
Gospodarowicz, D., Cohen, D. and Fujii, D.K. Cold Spring Harbor Conf. Cell Prolif. 9:95, 1982.
Nicholson, G. Biochim. Biophys. Acta 457:57–108, 1976.
Unkeless, J.C., Tobia, A., Ossowski, L., Quigley, J.P., Rifkin, D.B. and Reich, E. J. Exp. Med. 137:85-lll, 1973.
Liotta, L.A., Abe, S., Robey, P.G. and Martin, G.R. Proc. Natl. Acad. Sci. USA 75: 5417–5421, 1979.
Rifkin, D.B.L., Crowe, R.M. and Pollack, R. Cell 18:361–368, 1979.
Liotta, L.A., Rao, C.N. and Barsky, S.H. Lab. Invest. 49:636–649, 1983.
Tökes, Z.A. In: Breast Cancer: Origins, Detection, and Treatment (Eds. M.A. Rich, J.C. Hagor and J. Taylor-Papadimitriou), Martinus Nijhoff Publishing, Boston, pp. 131–155, 1986.
Emerman, J.T., Bartley, J.C and Bissell, M.J. Biochem. J. 192:695–702, 1981.
Lee, E.Y.-H., Lee W.-H., Kaetzel. CS., Parry, G. and Bissell, M.J. Proc. Natl. Acad. Sci. USA 82:1419–1423, 1985.
Parry, G., Lee, E.Y.-H., Farson, D., Koval, M. and Bissell, M.J. Exp. Cell Res. 156:487–499, 1985.
Li, M.L., Aggeler, J., Farson, D.A., Hatier, C, Hassell, J. and Bissell, M.J. Proc. Natl. Acad. Sci. USA 84:136–140, 1987.
Shannon, J.M. and Pitelka, D.R. In Vitro 17:1016–1028, 1981.
Haeuptle, M.-T., Suard, Y.L.M., Bogenmann, E., Reggio, H., Racine, L. and Kraehenbuhl, J.P. J. Cell Biol. 96:1425–1434, 1983.
Ringo, D.L. and Rocha, V. Exp. Cell Res. 147:216–220, 1983.
Rocha, V., Ringo, D.L. and Read, D.B. Exp. Cell Res. 159:201–210, 1985.
Wicha, M.S. In: New Approaches to the Study of Benign Prostatic Hyperplasia, Alan R. Liss, Inc., New York, pp. 129–142, 1984.
Danielson, K.G., Oborn, C.J., Durban, E.M., Butel, J.S. and Medina, D. Proc. Natl. Acad. Sci. USA 81:3756–3760, 1984.
Bissell, M.J., Lee E.Y.-H., Li, M.L. and Hall, H.G. Proceedings, The Second NIADDK Symposium on the Study of Benign Prostatic Hyperplasia, U.S. Government Printing Office, in press, 1986b.
Lee, E.Y.-H., Barcellos-Hoff, M.H., Chen, L.-H., Parry, G. and Bissell, M.J. In press, In Vitro Cell & Molec. Biol., 1987.
Chen, L.-H., Li, M.L. and Bissell, M.J. J. Cell Biol. 103: 178a, 1986.
Parry, G., Lee, E.Y.H. and Bissell, N.J. In: The Extracellular Matrix (Eds. S.P. Hawkes and J. Wang), Academic Press, New York, pp. 303–308, 1982.
Bissell, M.J., Li, M.L., Chen, L.-H. and Lee, E.Y.-H. In: Growth and Differentiation of Mammary Epithelial Cells in Culture (Eds. J. Enami and R. Ham), Academic Press, Japan, 1986a, in press.
Medina, D., Li, M.L., Oborn, C.J. and Bissell, M.J. Exp. Cell Res., in press, 1987.
Topper, Y.J. and Freeman, C.S. Physiol. Rev. 60:1049–1106, 1980.
Rosen, J.M., Matusick, R.J., Rochards, D.A., Gupta, P. and Rodgers, J.R. Recent Prog. Horm. Res. 36:157–193, 1980.
Bissell, M.J. and Aggeler, J. In: Mechanisms of Signal Transduction by Hormones and Growth Factors (Ed. M. Babot), Alan R. Liss, Inc., New York, in press, 1987.
Rosen, J.M., Rodgers, J.R., Couch, C.H., Bisbee, CA., David-Inouye, Y., Campbell, S.M. and Yu-Lee, L.Y. In: Metabolic Regulation: Application of Recombinant DNA Techniques (Eds. R. Hanson and A. Goodridge), Annal. N.Y. Acad. Sci., New York, 478:63–76, 1986.
McKeon, F.D., Kirschner, M.W. and Caput D. Nature 319:462–468, 1986.
Aebi, U., Cohn J., Buhle, L. and Gerace, L. Nature 323:560–562, 1986.
Fey, E.G., Krachmalnic, G. and Penman, S. J. Cell Biol. 102:1654–1665, 1986.
Bissell, M.J. and Hall, H.G. In: The Mammary Gland: Development Regulation and Function (Eds. M.C. Neville and C. Daniel), Plenum Press, New York, in press, 1987.
Penman, S., Fulton, A., Capco, D., Ben Ze’ev, A., Wittelsberger, S. and Tse, CF. Cold Spring Harbor Symp. Quant. Biol. 46:1013–1028, 1981.
Ingber, D.E., Madri, J.A. and Jamieson, J.D. In: Gene Expression during Normal and Malignant Differentiation (Eds. L.C. Andersson, C.G. Grahmberg and P. Ekblom), Academic Press, London, pp. 129–139, 1985.
Ingber, D.E. and Folkman, J. In: Mechanisms of Signal Transduction by Hormones and Growth Factors (Ed. M. Cabot), Alan R. Liss, Inc., New York, in press, 1987.
Sakakura, T. In: Understanding Breast Cancer. Clinical and Laboratory Concepts (Eds. M.A. Rich, J.C Hager and P. Furmanski), Marcel Dekker, Inc., New York, pp. 261–284, 1983.
Chiquet-Ehrismann, R., Mackie, E.J., Pearson, C.A. and Sakakura, T. Cell 47:131–139, 1986.
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Bissell, M.J., Aggeler, J. (1988). Regulation of Tissue-Specific Gene Expression in the Mammary Gland: The Role of the Extracellular Matrix. In: Rich, M.A., Hager, J.C., Lopez, D.M. (eds) Breast Cancer: Scientific and Clinical Progress. Developments in Oncology, vol 56. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1753-1_9
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DOI: https://doi.org/10.1007/978-1-4613-1753-1_9
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