Skip to main content
SpringerLink
Log in
Book cover

Breast Cancer: Scientific and Clinical Progress pp 127–141Cite as

Regulation of Tissue-Specific Gene Expression in the Mammary Gland: The Role of the Extracellular Matrix

  • Chapter

  • 36 Accesses

Part of the book series: Developments in Oncology ((DION,volume 56))

Abstract

Specific interactions between cells and the extracellular matrix (ECM) with which they are in contact play a vital role in tissue organization (1,2). Such interactions are important for directed migration of embryonic cells during development (1,3,4), and for tissue induction during morphogenesis (3,4). It has been established in many model systems, of which the mammary gland is a prime example, that ECM components can support induction and maintenance of tissue-specific function in epithelial cells placed in culture (5,6,7). One important feature of this induction is the modulation of cell shape by interaction with ECM components (5,6,8). In addition to its effects in regulating cell shape and differentiated gene expression, the ECM also exerts an important influence on cell growth and division (10). In transformed cells, progressive loss of differentiated function, altered morphology, and unchecked growth reflect loss of the ability to respond to the external signals that control these functions in normal cells (11).

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Wessells, N.K. Tissue Interactions and Development, Benjamin/ Cummings, Calif., 1977.

    Google Scholar 

  2. Hay, E.D. Mod. Cell. Biol. 2: 509–548, 1983.

    Google Scholar 

  3. Adamson, E.D. In: Collagen in Health and Disease (Eds. J.B. Weiss and M.I.V. Jayson), Churchill Livingstone, Edinburgh, 1982, pp. 218–243.

    Google Scholar 

  4. Tucker, R.P. and Erickson, C.A. Dev. Biol. 104: 390–405, 1984.

    Article  PubMed  CAS  Google Scholar 

  5. Emerman, J.T. and Pitelka, D.R. In Vitro 13:316–327, 1977.

    Article  PubMed  CAS  Google Scholar 

  6. Bissell, M.J., Hall, H.G. and Parry, G. J. Theoret. Biol. 99:31–68, 1982.

    Article  CAS  Google Scholar 

  7. Lee, E.Y.-H., Parry, G. and Bissell, M.J. J. Cell Biol. 98:146–155, 1984.

    Article  PubMed  CAS  Google Scholar 

  8. Kleinman, H.K., McGarvey, M.L., Hassell, J.R., Star, C.L., Cannon, F.B., Laurie, G.W. and Martin, G.R. Biochemistry 25:312–318, 1986.

    Article  PubMed  CAS  Google Scholar 

  9. Watt, F. Trends Biochem. Sci. 11: 482–485, 1986.

    Article  CAS  Google Scholar 

  10. Gospodarowicz, D., Cohen, D. and Fujii, D.K. Cold Spring Harbor Conf. Cell Prolif. 9:95, 1982.

    CAS  Google Scholar 

  11. Nicholson, G. Biochim. Biophys. Acta 457:57–108, 1976.

    Google Scholar 

  12. Unkeless, J.C., Tobia, A., Ossowski, L., Quigley, J.P., Rifkin, D.B. and Reich, E. J. Exp. Med. 137:85-lll, 1973.

    Article  Google Scholar 

  13. Liotta, L.A., Abe, S., Robey, P.G. and Martin, G.R. Proc. Natl. Acad. Sci. USA 75: 5417–5421, 1979.

    Google Scholar 

  14. Rifkin, D.B.L., Crowe, R.M. and Pollack, R. Cell 18:361–368, 1979.

    Article  PubMed  CAS  Google Scholar 

  15. Liotta, L.A., Rao, C.N. and Barsky, S.H. Lab. Invest. 49:636–649, 1983.

    PubMed  CAS  Google Scholar 

  16. Tökes, Z.A. In: Breast Cancer: Origins, Detection, and Treatment (Eds. M.A. Rich, J.C. Hagor and J. Taylor-Papadimitriou), Martinus Nijhoff Publishing, Boston, pp. 131–155, 1986.

    Google Scholar 

  17. Emerman, J.T., Bartley, J.C and Bissell, M.J. Biochem. J. 192:695–702, 1981.

    Google Scholar 

  18. Lee, E.Y.-H., Lee W.-H., Kaetzel. CS., Parry, G. and Bissell, M.J. Proc. Natl. Acad. Sci. USA 82:1419–1423, 1985.

    Article  CAS  Google Scholar 

  19. Parry, G., Lee, E.Y.-H., Farson, D., Koval, M. and Bissell, M.J. Exp. Cell Res. 156:487–499, 1985.

    Article  PubMed  CAS  Google Scholar 

  20. Li, M.L., Aggeler, J., Farson, D.A., Hatier, C, Hassell, J. and Bissell, M.J. Proc. Natl. Acad. Sci. USA 84:136–140, 1987.

    Article  PubMed  CAS  Google Scholar 

  21. Shannon, J.M. and Pitelka, D.R. In Vitro 17:1016–1028, 1981.

    Article  PubMed  CAS  Google Scholar 

  22. Haeuptle, M.-T., Suard, Y.L.M., Bogenmann, E., Reggio, H., Racine, L. and Kraehenbuhl, J.P. J. Cell Biol. 96:1425–1434, 1983.

    Article  PubMed  CAS  Google Scholar 

  23. Ringo, D.L. and Rocha, V. Exp. Cell Res. 147:216–220, 1983.

    Article  PubMed  CAS  Google Scholar 

  24. Rocha, V., Ringo, D.L. and Read, D.B. Exp. Cell Res. 159:201–210, 1985.

    Article  PubMed  CAS  Google Scholar 

  25. Wicha, M.S. In: New Approaches to the Study of Benign Prostatic Hyperplasia, Alan R. Liss, Inc., New York, pp. 129–142, 1984.

    Google Scholar 

  26. Danielson, K.G., Oborn, C.J., Durban, E.M., Butel, J.S. and Medina, D. Proc. Natl. Acad. Sci. USA 81:3756–3760, 1984.

    Article  PubMed  CAS  Google Scholar 

  27. Bissell, M.J., Lee E.Y.-H., Li, M.L. and Hall, H.G. Proceedings, The Second NIADDK Symposium on the Study of Benign Prostatic Hyperplasia, U.S. Government Printing Office, in press, 1986b.

    Google Scholar 

  28. Lee, E.Y.-H., Barcellos-Hoff, M.H., Chen, L.-H., Parry, G. and Bissell, M.J. In press, In Vitro Cell & Molec. Biol., 1987.

    Google Scholar 

  29. Chen, L.-H., Li, M.L. and Bissell, M.J. J. Cell Biol. 103: 178a, 1986.

    Google Scholar 

  30. Parry, G., Lee, E.Y.H. and Bissell, N.J. In: The Extracellular Matrix (Eds. S.P. Hawkes and J. Wang), Academic Press, New York, pp. 303–308, 1982.

    Google Scholar 

  31. Bissell, M.J., Li, M.L., Chen, L.-H. and Lee, E.Y.-H. In: Growth and Differentiation of Mammary Epithelial Cells in Culture (Eds. J. Enami and R. Ham), Academic Press, Japan, 1986a, in press.

    Google Scholar 

  32. Medina, D., Li, M.L., Oborn, C.J. and Bissell, M.J. Exp. Cell Res., in press, 1987.

    Google Scholar 

  33. Topper, Y.J. and Freeman, C.S. Physiol. Rev. 60:1049–1106, 1980.

    PubMed  CAS  Google Scholar 

  34. Rosen, J.M., Matusick, R.J., Rochards, D.A., Gupta, P. and Rodgers, J.R. Recent Prog. Horm. Res. 36:157–193, 1980.

    PubMed  CAS  Google Scholar 

  35. Bissell, M.J. and Aggeler, J. In: Mechanisms of Signal Transduction by Hormones and Growth Factors (Ed. M. Babot), Alan R. Liss, Inc., New York, in press, 1987.

    Google Scholar 

  36. Rosen, J.M., Rodgers, J.R., Couch, C.H., Bisbee, CA., David-Inouye, Y., Campbell, S.M. and Yu-Lee, L.Y. In: Metabolic Regulation: Application of Recombinant DNA Techniques (Eds. R. Hanson and A. Goodridge), Annal. N.Y. Acad. Sci., New York, 478:63–76, 1986.

    Google Scholar 

  37. McKeon, F.D., Kirschner, M.W. and Caput D. Nature 319:462–468, 1986.

    Article  Google Scholar 

  38. Aebi, U., Cohn J., Buhle, L. and Gerace, L. Nature 323:560–562, 1986.

    Article  PubMed  CAS  Google Scholar 

  39. Fey, E.G., Krachmalnic, G. and Penman, S. J. Cell Biol. 102:1654–1665, 1986.

    Article  PubMed  CAS  Google Scholar 

  40. Bissell, M.J. and Hall, H.G. In: The Mammary Gland: Development Regulation and Function (Eds. M.C. Neville and C. Daniel), Plenum Press, New York, in press, 1987.

    Google Scholar 

  41. Penman, S., Fulton, A., Capco, D., Ben Ze’ev, A., Wittelsberger, S. and Tse, CF. Cold Spring Harbor Symp. Quant. Biol. 46:1013–1028, 1981.

    CAS  Google Scholar 

  42. Ingber, D.E., Madri, J.A. and Jamieson, J.D. In: Gene Expression during Normal and Malignant Differentiation (Eds. L.C. Andersson, C.G. Grahmberg and P. Ekblom), Academic Press, London, pp. 129–139, 1985.

    Google Scholar 

  43. Ingber, D.E. and Folkman, J. In: Mechanisms of Signal Transduction by Hormones and Growth Factors (Ed. M. Cabot), Alan R. Liss, Inc., New York, in press, 1987.

    Google Scholar 

  44. Sakakura, T. In: Understanding Breast Cancer. Clinical and Laboratory Concepts (Eds. M.A. Rich, J.C Hager and P. Furmanski), Marcel Dekker, Inc., New York, pp. 261–284, 1983.

    Google Scholar 

  45. Chiquet-Ehrismann, R., Mackie, E.J., Pearson, C.A. and Sakakura, T. Cell 47:131–139, 1986.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Lab. Cell Biology, Lawrence Berkeley Lab., Berkeley, CA, 94720, USA

    Mina J. Bissell

  2. Dept. of Human Anatomy, School of Medicine, University of California, Davis, CA, 95616, USA

    Judith Aggeler

Authors
  1. Mina J. Bissell
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Judith Aggeler
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. AMC Cancer Research Center, Denver, CO, 80214, USA

    Marvin A. Rich  & Jean C. Hager  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Kluwer Academic Publishers, Boston

About this chapter

Cite this chapter

Bissell, M.J., Aggeler, J. (1988). Regulation of Tissue-Specific Gene Expression in the Mammary Gland: The Role of the Extracellular Matrix. In: Rich, M.A., Hager, J.C., Lopez, D.M. (eds) Breast Cancer: Scientific and Clinical Progress. Developments in Oncology, vol 56. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1753-1_9

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-1753-1_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8984-5

  • Online ISBN: 978-1-4613-1753-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation