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Quantitative and Qualitative Changes in Oncogene Expression During Carcinogenesis

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Breast Cancer: Scientific and Clinical Progress

Part of the book series: Developments in Oncology ((DION,volume 56))

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Abstract

Functional analysis of the human H-ras 1 gene has revealed the presence of transcriptional regulatory sequences at the 5′ and 3′ end of the gene. In addition, in vitro cell transformation studies have demonstrated that both quantitative and qualitative changes in ras oncogene expression could trigger one or more of the following transformed cell phenotypes: 1. Immortalization of early passage cells, 2. Anchorage independence or tumorigenicity, and 3. Metastatic properties of the cells. Thus, ras genes cannot be rigidly classified as stage specific genes in the multistage process of carcinogenesis.

Molecular hybridization analysis using oncogene DNA probes and immunohistochemical studies employing monoclonal antibodies to the ras p21 protein have also shown that ras oncogenes can be activated by quantitative and qualitative changes in oncogene expression in human tumor biopsies and cell lines. Transcriptional activation of the H-ras gene in breast tumors is a frequent event.

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Author information

Authors and Affiliations

  1. Hellenic Institue Pasteur, 127 Vass Sofias Ave, Athens, Greece

    D. A. Spandidos, A. Pintzas, A. Kakkanas & M. Yiagnisis

  2. The Beatson Institute for Cancer Research, Garscube Estate, Switchback Rd, Bearsden, Glasgow, G61 1BD, Scotland, UK

    D. A. Spandidos

  3. Hellenic Anticancer Institute, Athens, Greece

    N. J. Agnantis

Authors
  1. D. A. Spandidos
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  2. A. Pintzas
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  3. A. Kakkanas
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  4. M. Yiagnisis
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  5. N. J. Agnantis
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Editor information

Editors and Affiliations

  1. AMC Cancer Research Center, Denver, CO, 80214, USA

    Marvin A. Rich  & Jean C. Hager  & 

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© 1988 Kluwer Academic Publishers, Boston

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Spandidos, D.A., Pintzas, A., Kakkanas, A., Yiagnisis, M., Agnantis, N.J. (1988). Quantitative and Qualitative Changes in Oncogene Expression During Carcinogenesis. In: Rich, M.A., Hager, J.C., Lopez, D.M. (eds) Breast Cancer: Scientific and Clinical Progress. Developments in Oncology, vol 56. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1753-1_3

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  • DOI: https://doi.org/10.1007/978-1-4613-1753-1_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8984-5

  • Online ISBN: 978-1-4613-1753-1

  • eBook Packages: Springer Book Archive

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