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Nuclear DNA Content and Prognosis in Breast Cancer

  • Chapter
Breast Cancer: Scientific and Clinical Progress

Part of the book series: Developments in Oncology ((DION,volume 56))

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Abstract

Prognosis — the prediction of the duration, course, and outcome of disease in an individual patient — is an essential part of medical practice. The more precise the methods available are the better our possibilities for individualized therapy. In breast cancer this is a challenging problem. Mammography has resulted in the detection of an increased proportion of small, preclinical turaprs for which the proper treatment is controversial (1). Concepts regarding breast cancer surgery have been changing (2,3). In addition, the recent improvement in hormonal therapy, including the development of antiestrogen compounds and cytotoxic therapies, have widened the therapeutic spectrum. However, traditional ways of subgrouping patients into various prognostic groups by clinical staging and histomorphological grading have been proven to be inaccurate and too subjective for prognostication in the individual patient (4–8). Therefore, new approaches for tumor grading in breast cancer have been proposed.

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Authors and Affiliations

  1. Department of Tumor Pathology, Karolinska Institute, Karolinska Hospital, S-104 01, Stockholm, Sweden

    A. Fallenius & G. Auer

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  1. A. Fallenius
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  2. G. Auer
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Editors and Affiliations

  1. AMC Cancer Research Center, Denver, CO, 80214, USA

    Marvin A. Rich  & Jean C. Hager  & 

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© 1988 Kluwer Academic Publishers, Boston

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Fallenius, A., Auer, G. (1988). Nuclear DNA Content and Prognosis in Breast Cancer. In: Rich, M.A., Hager, J.C., Lopez, D.M. (eds) Breast Cancer: Scientific and Clinical Progress. Developments in Oncology, vol 56. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1753-1_18

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  • DOI: https://doi.org/10.1007/978-1-4613-1753-1_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8984-5

  • Online ISBN: 978-1-4613-1753-1

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