The Possible Role of Abnormal Fibroblasts in the Pathogenesis of Breast Cancer

  • S. L. Schor
  • A. M. Schor
  • A. Howell
  • J. Haggie
Part of the Developments in Oncology book series (DION, volume 56)

Abstract

Fibroblasts obtained from patients with epithelial tumors have generally been considered to be normal cells. There is, however, a growing body of data indicating these fibroblasts may express a number of aberrant behavioral characteristics commonly associated with transformation. In this communication, we shall (a) review the evidence for the presence of such aberrant fibroblasts in cancer patients, (b) discuss the possible role played by these cells in the pathogenesis of breast cancer, and (c) consider the clinical implications of these findings.

Keywords

Migration Polypeptide Macromolecule Plasminogen 

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Copyright information

© Kluwer Academic Publishers, Boston 1988

Authors and Affiliations

  • S. L. Schor
    • 1
  • A. M. Schor
    • 2
  • A. Howell
    • 2
  • J. Haggie
    • 2
  1. 1.Dept. of Cell and Structural BiologyManchester UniversityManchesterEngland
  2. 2.CRC Dept. of Medical OncologyChristie HospitalManchesterEngland

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