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Malignant Melanoma: Biology, Diagnosis, and Therapy pp 123–153Cite as

Radioimmunoimaging of malignant melanoma with monoclonal antibodies

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Part of the book series: Cancer Treatment and Research ((CTAR,volume 43))

Abstract

Malignant melanoma is currently the only cancer besides lung cancer that is increasing in incidence, with approximately 24,000 new cases diagnosed per year [1]. Although localized disease can be cured by surgery if discovered early, regional or disseminated disease is seldom curable. Overall response rates to single-agent or combination chemotherapy as well as overall survival have not changed appreciably over the past 15 years [2]. Therefore, the development of new diagnostic as well as therapeutic modalities for this disease remains of paramount importance.

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References

  1. Fears TR, Scotto J: Changes in skin cancer morbidity between 1971–72 and 1977–78. J Natl Cancer Inst 69:365–370, 1982.

    PubMed  CAS  Google Scholar 

  2. Coates AS, Durant JR: Chemotherapy for metastatic melanoma. In: Cutaneous melanoma: Clinical management and treatment results worldwide, Balch CM, Milton GW (eds). Philadelphia: J.B. Lippincott, 1985, pp. 275–282.

    Google Scholar 

  3. Kohler G, Milstein C: Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256:495–497, 1975.

    Article  PubMed  CAS  Google Scholar 

  4. Herlyn M, Steplewski Z, Herlyn I, et al: Production and characterization of monoclonal antibodies against human malignant melanoma. Cancer Invest 1:215–224, 1983.

    Article  PubMed  CAS  Google Scholar 

  5. Deland FH, Goldenberg DM: Diagnosis and treatment of neoplasms with radionuclide-labeled antibodies. Semin Nucl Med 15(1):2–11, 1985.

    Article  PubMed  CAS  Google Scholar 

  6. Goldenberg DM, Deland FH: History and status of tumor imaging with radiolabeled antibodies. J Biol Resp Modif 1:121–132, 1982.

    Google Scholar 

  7. Ghose T, Tai J, Aquino J, Guclu A, Norvell ST, MacDonald AS: Tumor localization of 131I-labeled antibodies by radionuclide imaging. Radiology 116:445–448, 1975.

    PubMed  CAS  Google Scholar 

  8. Ghose T, Guclu A, Tai J, MacDonald AS, Norvell ST, Aquino J: Antibody as a carrier of 131I in cancer diagnosis and treatment. Cancer 36:1646–1657, 1975.

    Article  PubMed  CAS  Google Scholar 

  9. Ghose T, Tai J, Novell ST, Guclu A, MacDonald AS: Antibodies as carriers of radionuclides and cytotoxic drugs in the treatment and diagnosis of cancer. Ann NY Acad Sci 277:671–689, 1976.

    Article  PubMed  CAS  Google Scholar 

  10. Goldenberg DM, DeLand F, Kim E, et al: Use of radiolabeled antibodies to carcino-embryonic antigen for the detection and localization of diverse cancers by external photo-scanning. N Engl J Med 298:1384–1388, 1978.

    Article  PubMed  CAS  Google Scholar 

  11. Ghose T, Ferrone S, Imai K, et al: Imaging of human melanoma xenografts in nude mice with a radiolabeled monoclonal antibody. J Nat Cancer Inst 69:823–826, 1982.

    PubMed  CAS  Google Scholar 

  12. Wilson BS, Kohzoh I, Natali PG, Ferrone S: Distribution and characterization of a cell-surface and a cytoplasmic antigen detectable in human melanoma cells with monoclonal antibodies. Int J Cancer 28:293–300, 1981.

    Article  PubMed  CAS  Google Scholar 

  13. Hwang KM, Fodstad O, Oldham RK, Morgan AC Jr: Radiolocalization of xenografted human malignant melanoma by a monoclonal antibody (9.2.27) to a melanoma-associated antigen in nude mice. Cancer Res 45:4150–4155, 1985.

    PubMed  CAS  Google Scholar 

  14. Morgan AC, Galloway DR, Reisfeld RA: Production and characterization of monoclonal antibody to a melanoma specific glycoprotein. Hybridoma 1:27–36, 1981.

    Article  PubMed  CAS  Google Scholar 

  15. Beaumier PL, Krohn KA, Carrasquillo JA, et al. Melanoma localization in nude mice with monoclonal Fab against p97. J Nucl Med 26:1172–1179, 1985.

    PubMed  CAS  Google Scholar 

  16. Brown JP, Nishiyama K, Hellstrom I, et al: Structural characterization of human melanoma-associated antigen p97 with monoclonal antibodies. J Immunol 127:539–546, 1981.

    PubMed  CAS  Google Scholar 

  17. Brown JP, Woodbury RG, Hart CE, et al: Quantitative analysis of melanoma-associated antigen p97 in normal and neoplastic tissues. Proc Natl Acad Sci (USA) 78:539–543, 1981.

    Article  CAS  Google Scholar 

  18. Pressman D, Day ED, Blau M: The use of paired labeling in the determination of tumor-localizing antibodies. Cancer Res 17:845–850, 1957.

    PubMed  CAS  Google Scholar 

  19. Larson SM, Brown JP, Wright PW, Carrasquillo JA, Hellstrom I, Hellstrom KE: Imaging of melanoma with I-131-labeled monoclonal antibodies. J Nucl Med 24(2): 123–129, 1983.

    PubMed  CAS  Google Scholar 

  20. DeLand FH, Kimm EE, Simmons G, Goldenberg DM: Imaging approach in radioimmuno-detection. Cancer Res 40:3046–3049, 1980.

    PubMed  CAS  Google Scholar 

  21. Fairweather DS, Bradwell AR, Dykes PW: Nuclear imaging techniques with radiolabeled antibodies. J Pathol 141:363–378, 1983.

    Article  PubMed  CAS  Google Scholar 

  22. Larson SM, Carrasquillo JA, Krohn KA, et al: Localization of 131I-labeled p97-specific Fab fragments in human melanoma as a basis for radiotherapy. J Clin Invest 72:2101–2114, 1983.

    Article  PubMed  CAS  Google Scholar 

  23. Buraggi GL, Callegaro L, Mariani G, et al: Imaging with 131I-labeled monoclonal antibodies to a high molecular weight melanoma-associated antigen in patients with melanoma: Efficacy of whole immunoglobulin and its F(ab’)2 fragments. Cancer Res 45:3378–3387, 1985.

    PubMed  CAS  Google Scholar 

  24. Larson SM: Radiolabeled monoclonal anti-tumor antibodies in diagnosis and therapy. J Nucl Med 26:538–545, 1985.

    PubMed  CAS  Google Scholar 

  25. Moshakis V, McIlhinney RAJ, Raghaven D: Monoclonal antibodies to detect human tumors: An experimental approach. J Clin Pathol 34:314–319, 1981.

    Article  PubMed  CAS  Google Scholar 

  26. Epenetos AA, Snook D, Durbin H, et al: Limitations of radiolabeled monoclonal antibodies for localization of human neoplasms. Cancer Res 46:3183–3191, 1986.

    PubMed  CAS  Google Scholar 

  27. Eckelman WC, Paik CH, Reba RC: Radiolabeling of antibodies. Cancer Res 40:3036–3042, 1980.

    PubMed  CAS  Google Scholar 

  28. Benisek WF, Richards FM: Attachment of metal chelating functional groups to hen egg-white lysozyme. J Biol Chem 243:4267–4271, 1968.

    PubMed  CAS  Google Scholar 

  29. Krejcarek GE, Tucker KL: Covalent attachment of chelating groups to macromolecules. Biochem Biophys Res Comm 177:581–585, 1977.

    Article  Google Scholar 

  30. Goodwin DA, Meares CF, McCall MJ, et al: Chelate conjugates of monoclonal antibodies for imaging lymphoid structures in the mouse. J Nucl Med 26:493–502, 1985.

    PubMed  CAS  Google Scholar 

  31. Paik CH, Hong JJ, Ebbert MA, Heald SC, Reba RC, Eckelman WC: Relative reactivity of DTPA immunoreactive antibody—DTPA conjugates, and nonimmunoreactive antibody— DTPA conjugates toward 111In. J Nucl Med 26:482–487, 1985.

    PubMed  CAS  Google Scholar 

  32. Fawwaz RA, Wang TST, Estabrook A, et al: Immunoreactivity and biodistribution of 111In-labeled monoclonal antibody to a human high-molecular-weight melanoma-associated antigen. J Nucl Med 26:448–492, 1985.

    Google Scholar 

  33. Sakahara H, Endo K, Nakashima T, et al: Effect of DTPA conjugation on the antigen binding activity and biodistribution of monoclonal antibodies against alpha-fetoprotein. J Nucl Med 26:750–755, 1985.

    PubMed  CAS  Google Scholar 

  34. Metzger JM, Seeker-Walker RH, Krohn KA, Welch MJ, Potchin EJ: Unsatisfactory biologic behavior of I*-fibrenogen labeled by the chloramic T method. J Lab Clin Med 82:267–275, 1973.

    PubMed  CAS  Google Scholar 

  35. Stern P, Hagan P, Halpern S, et al: The effect of radiolabel on the kinetics of the monoclonal anti-CEA in a nude mouse-colon tumor model. In: Hybridomas in cancer diagnosis and treatment, Mitchell MS, Oettgen HF (eds). New York: Raven Press, 1982, pp. 245–253.

    Google Scholar 

  36. Halpern SE, Hagan PL, Garver PR, et al: Stability, characterization, and kinetics of 111In-labeled monoclonal antitumor antibodies in normal animals and nude mouse-human tumor models. Cancer Res 43:5347–5355, 1983.

    PubMed  CAS  Google Scholar 

  37. Bernhard MI, Hwang KM, Foon KA, et al: Localization of 111In- and 125I-labeled monoclonal antibody in guinea pigs bearing line 10 hepatocarcinoma tumors. Cancer Res 43:4429–4433, 1987.

    Google Scholar 

  38. Halpern SE, Dillman RO: Problems associated with radioimmunodetection and possibilities for future solutions. J Biol Resp Modif 6:235–262, 1987.

    CAS  Google Scholar 

  39. Murray JL, Hersh EM, Rosenblum MG, et al: Radioimmunoimaging in malignant melanoma using 111indium-labeled anti-p97 monoclonal antibody. In: Monoclonal antibodies: Diagnostic and therapeutic use in tumor and transplantation, Chatterjee S (ed). Littleton, Mass.: PSG Publishing, 1985, pp. 143–153.

    Google Scholar 

  40. Murray JL, Rosenblum MG, Sobol RE, et al: Radioimmunoimaging in malignant melanoma with 111In-labeled monoclonal antibody 96.5. Cancer Res 45:2376–2381, 1985.

    PubMed  CAS  Google Scholar 

  41. Rosenblum MG, Murray JL, Haynie TP, et al: Pharmacokinetics of 111In-labeled anti-p97 monoclonal antibody in patients with metastatic malignant melanoma. Cancer Res 45: 2382–2386, 1985.

    PubMed  CAS  Google Scholar 

  42. Murray JL, Rosenblum MG, Lamki L, et al: Clinical parameters related to optimal tumor localization of 111indium-labeled mouse antimelanoma monoclonal antibody ZME 018. J Nucl Med 28:25–33, 1987.

    PubMed  CAS  Google Scholar 

  43. Murray JL, Rosenblum MG, Lamki L, Haynie TP, Hersh EM: Radioimmunoimaging in malignant melanoma patients using 111indium-labeled antimelanoma monoclonal antibody (ZME 018) to a high molecular weight antigen Kd200. NCI Monographs 3:3–9, 1987.

    PubMed  Google Scholar 

  44. Rosenblum MG, Murray JL, Lamki L, et al: Comparative clinical pharmacology of the two antimelanoma antibodies, ZME 018 and 96.5, labeled with 111indium. Cancer Chemother Pharmacol 20:41–47, 1987.

    Article  PubMed  CAS  Google Scholar 

  45. Halpern SE, Dillman RO, Witztum KF, et al: Radioimmunodetection of melanoma utilizing 111In-96.5 monoclonal antibody: A preliminary report. Radiology 155:493–499.

    Google Scholar 

  46. Taylor A, Milton W, Eyre H, et al: Radioimmunodetection of human melanoma utilizing 111In-labeled monoclonal antibodies. NCI Monographs 3:25–31, 1987.

    PubMed  Google Scholar 

  47. Kirkwood JM, Neuman RD, Zoghbi S, et al: Scintigraphic detection of metastatic melanoma using indium-111/DTPA conjugated anti-gp 240 antibody (ZME 018). J Clin Oncol 5:1247–1255, 1987.

    PubMed  CAS  Google Scholar 

  48. Siccardi AG, Buraggi GL, Callegaro L, et al: Multicenter study of immunoscintigraphy with radiolabeled monoclonal antibodies in patients with melanoma. Cancer Res 46:4817–4822, 1986.

    PubMed  CAS  Google Scholar 

  49. Morrison RT, Lyster DM, Alcorn L, Rhodes BA, Breslow K, Burchiel SW: Radioimmunoimaging with 99mTc monoclonal antibodies: Clinical studies. Int J Nucl Med Biol 11(2): 184–188, 1984.

    Article  PubMed  CAS  Google Scholar 

  50. Eary J, Schroff R, Abrams P, et al: Radioimaging of melanoma with TC-99 m labeled monoclonal antibodies. Proc AACR 356 (abstract), 1987.

    Google Scholar 

  51. Fitzberg AR: Radiopharmaceutical chemistry V: Antibodies. J Nucl Med 27:957–958, 1986.

    Google Scholar 

  52. Anderson WT, Strand M: Stability, targeting, and biodistribution of scandium-46- and gallium-67-labeled monoclonal antibody in erythroleukemic mice. Cancer Res 45:2154–2158, 1985.

    PubMed  CAS  Google Scholar 

  53. Gansow OA, Atcher RW, Link DW, et al: Generator-produced Bi-212 chelated to chemically modified monoclonal antibody for use in radiotherapy. In: Radionuclide generators: New systems for nuclear medicine applications, Knapp FF Jr, Butler JA (eds). Washington, D.C.: American Chemical Society, 241:215–230, 1984.

    Chapter  Google Scholar 

  54. Bateman WJ, Vaughan ADM, Brown G: Tumor localization of 211At-labeled monoclonal antibody to a subcutaneous human heterograft in the nude mouse II:. Int J Nucl Med 10(4):241–242, 1983.

    Article  CAS  Google Scholar 

  55. Wessels BW, Tryba S, Griffith H, et al: Direct absorbed doses measurements of Y-90 labeled melanoma monoclonal antibodies in tumored mice. Cancer Drug Deliv 2:221–222, 1985.

    Google Scholar 

  56. Mann BD, Cohen MB, Saxton RE, et al: Imaging of human tumor xenografts in nude mice with monoclonal antibodies: Limitations of specificity due to nonspecific uptake of antibody. Cancer 54:1318–1327, 1984.

    Article  PubMed  CAS  Google Scholar 

  57. Bailou B, Jaffe R, Taylor RJ, Solter D, Hakala TR: Tumor radioimmunolocation: Differential antibody retention by antigenic normal tissue and tumor. J Immunol 132:2111–2116, 1984.

    Google Scholar 

  58. Hayes DF, Zalutsky MR, Kaplan W, et al: Pharmacokinetics of radiolabeled monoclonal antibody B6.2 in patients with metastatic breast cancer. Cancer Res 46:3157–3163, 1986.

    PubMed  CAS  Google Scholar 

  59. Colcher D, Zalutsky ML, Kaplan W, Kube D, Austin F, Schlom J: Radiolocalization of human mammary tumors in athymic mice by a monoclonal antibody. Cancer Res 43:736–742, 1983.

    PubMed  CAS  Google Scholar 

  60. Dillman R, Beuregard J, Sobol R, et al: Lack of radioimmunodetection and complications associated with monoclonal anticarcinoembryonic antigen antibody cross-reactivity with an antigen on circulating cells. Cancer Res 46:3157–3163, 1984.

    Google Scholar 

  61. Shawler DL, Bartholomew RM, Smith LM, Dillman RO: Human murine response to multiple injections of murine monoclonal IgG. J Immunol 135:1530–1535, 1985.

    PubMed  CAS  Google Scholar 

  62. Schroff RW, Foon KA, Beatty SM, Oldham RK, Morgan AC Jr: Human anti-murine immunoglobulin responses in patients receiving monoclonal antibody therapy. Cancer Research 45:879–885, 1985.

    PubMed  CAS  Google Scholar 

  63. Bron D, Delforge A, Stryckmans P: Human monoclonal antibodies: New approaches and perspectives in cancer. Eur J Cancer Clin Oncol 21 (3):283–285, 1985.

    Article  PubMed  CAS  Google Scholar 

  64. Kan-Mitchell J, Imam A, Kempf RA, Taylor CR, Mitchell MS: Human monoclonal antibodies directed against melanoma tumor-associated antigens. Cancer Res 46:2490–2496, 1986.

    PubMed  CAS  Google Scholar 

  65. Beauchamp CO, Gonias SL, Menapace DP, Pizzo SV: A new procedure for the synthesis of polyethylene glycol-protein adducts: Effects on function, receptor recognition, and clearance of superoxide dismutase, lactoferrin, and alpha2-macroglobulin. Ann Biochem 131:25–33, 1983.

    Article  CAS  Google Scholar 

  66. Marx JL: Antibodies made to order. Science 229:455–456, 1985.

    Article  PubMed  CAS  Google Scholar 

  67. Hagan P, Halpern S, Chen A, et al: In vivo kinetics of radiolabeled monoclonal anti-CEA antibodies in animal models. J Nucl Med 26:1418–1423, 1985.

    PubMed  CAS  Google Scholar 

  68. Steplewski Z, Lubeck MD, Koprowski H: Human macrophages armed with murine immunoglobulin G2a antibodies to tumor destroy human cancer cells. Science 221:865–867, 1983.

    Article  PubMed  CAS  Google Scholar 

  69. Murray JL, Lamki LM, Rosenblum MG, Carlo DJ, Unger MW: Effect of escalating doses of nonimmunoreactive (NIR) Mo Ab 96.5 A on liver uptake of tumor-specific (111In)-MoAb 96.5C. Proc AACR 28:384 (abstract), 1987.

    Google Scholar 

  70. Brown JP, Hevick RM, Hellstrom I, Hellstrom KE, Doolittle RF, Dreyer WJ: Human melanoma-associated antigen p97 is structurally and functionally related to transferrin. Nature 296:171–173, 1982.

    Article  PubMed  CAS  Google Scholar 

  71. Ward MC, Roberts KR, Westwood JH, Coombes RCC, McCready VR: The effect of chelating agents on the distribution of monoclonal antibodies in mice. J Nucl Med 27:1746–1750, 1986.

    PubMed  CAS  Google Scholar 

  72. Weinstein JN, Parker RJ, Keenan AM, Dower SK, Morse HC III, Sieber SM: Monoclonal antibodies in lymphatics: Toward the diagnosis and therapy of tumor metastases. Science 218:1334–1337, 1982.

    Article  PubMed  CAS  Google Scholar 

  73. Nelp WB, Eary JF, Jones RF, et al: Preliminary studies of monoclonal antibody lymphoscintigraphy in malignant melanoma. J Nucl Med 28:34–41, 1987.

    PubMed  CAS  Google Scholar 

  74. Frontiera M, Schmelter R, Chu H, et al: Immunolymphoscintigraphy with radiolabeled monoclonal antibodies in patients with malignant melanoma. Proc ASCO 6:213 (abstract), 1987.

    Google Scholar 

  75. Stickney DR, Gridley DS, Kirk GA: Enhancement of monoclonal antibody (MoAb) binding to melanoma with single dose radiation or hyperthermia. NCI Monographs 3:47–52, 1987.

    PubMed  Google Scholar 

  76. Davies C de L, Rofstad EK, Lindmo T: Hyperthermia-induced changes in antigen expression on human FME melanoma cells. Cancer Res 45:4109–4115, 1985.

    Google Scholar 

  77. Krizan Z, Murray JL, Hersh EM, et al: Increased labeling of human melanoma cells in vitro using combinations of monoclonal antibodies recognizing separate cell surface ante-genic determinants. Cancer Res 45:4904–4909, 1985.

    PubMed  CAS  Google Scholar 

  78. Cillo C, Mach JP, Schreyer M, Carrel S: Antigenic heterogeneity of clones and subclones from human melanoma cell lines demonstrated by a panel of monoclonal antibodies and flow microfluorimetry analysis. Int J Cancer 34:11–20, 1984.

    Article  PubMed  CAS  Google Scholar 

  79. Burchiel SW, Imai K, Ferrone S, Warner NL: Heterogeneity of cell surface antigen expression on human melanoma cells: Analysis with monoclonal antibodies and flow cytometry. Prog Cancer Res Ther 21:1951, 1982.

    Google Scholar 

  80. Dantas ME, Brown JP, Thomas MR, Robinson WA, Glode LM: Detection of melanoma cells in bone marrow using monoclonal antibodies: A comparison of fluorescence activated cell sorting (FACS) and conventional immunofluorescence (IF). Cancer 52:949–953, 1983.

    Article  PubMed  CAS  Google Scholar 

  81. Minz DL, Alavi A, Koprowski H, Herlyn D: Improved radioimmunoimaging of human tumor xenografts by a mixture of monoclonal antibody F(ab’)2; fragments. J Nucl Med 27:1739–1745, 1986.

    Google Scholar 

  82. Greiner JW, Hand PH, Noguchi P, Fisher PB, Pestka S, Schlom J: Enhanced expression of surface tumor-associated antigens on human breast and colon tumor cells after recombinant human leukocyte alpha-interferon treatment. Cancer Res 44:3208–3214, 1984.

    PubMed  CAS  Google Scholar 

  83. Giacomini P, Aguzzi A, Pestka S, Fisher PB, Ferrone S: Modulation by recombinant DNA leukocyte (α) and fibroblast (ß) interferons of the expression and shedding of HLA- and tumor-associated antigens by human melanoma cells. J Immunol 133(3): 1649–1655, 1984.

    PubMed  CAS  Google Scholar 

  84. Murray JL, Stuckey SE, Pillow JK, Rosenblum MG, Carlo DJ, Gutterman JU: Differential in vitro effects of recombinant alpha-interferon and recombinant gamma-interferon alone or in combination on the expression of melanoma associated surface antigens. J Biol Resp Modif 7:152–161, 1988.

    CAS  Google Scholar 

  85. Greiner JW, Guadagni F, Noguchi P, et al: Recombinant interferon enhances monoclonal antibody-targeting of carcinoma lesions in vivo. Science 235:895–898, 1987.

    Article  PubMed  CAS  Google Scholar 

  86. Rosenblum MG, Lamki LM, Murray JL, Carlo DJ, Gutterman JU: Interferon-induced changes in the pharmacokinetics and tumor uptake of 111In-labeled anti-melanoma antibody 96.5 in melanoma patients. JNCI 80:160–165, 1987.

    Google Scholar 

  87. Colcher D, Kennan AM, Larson SM, Schlom J: Prolonged binding of a radiolabeled monoclonal antibody (B72.3) used for the in situ radioimmunodetection of human colon carcinoma xenografts. Cancer Res 44:5744–5751, 1984.

    PubMed  CAS  Google Scholar 

  88. Badger CC, Krohn KA, Peterson AV, Schulman H, Bernstein ID: Experimental radiotherapy of murine lymphoma with 131I-labeled anti-Thy 1.1 monoclonal antibody. Cancer Res 45:1536–1544, 1985.

    PubMed  CAS  Google Scholar 

  89. Proffitt RT, Williams LE, Presant CA, et al: Liposomal blockage of the reticuloendothelial system: Improved tumor imaging with small unilamellar vesicles. Science 220:502–505, 1983.

    Article  PubMed  CAS  Google Scholar 

  90. Begent RHJ, Keep PA, Green AJ, et al: Liposomally entrapped second antibody improves tumor imaging with radiolabeled (first) antitumor antibody. Lancet 2:739–742, 1982.

    Article  PubMed  CAS  Google Scholar 

  91. Peterson JA and Ceriani RL: International workshop on monoclonal antibodies and breast cancer. In: Breast cancer research and treatment (Volume 5), Ceriani RL (ed). Boston; Martinus Nijhoff, 1985, pp. 207–214.

    Google Scholar 

  92. East IJ, Keenan AM, Larson CM, Dean J: Scintigraphy of normal mouse ovaries with monoclonal antibodies to ZP-2, the major zonal pellucida protein. Science 225:938–941, 1984.

    Article  PubMed  CAS  Google Scholar 

  93. Epenetos AA: Clinical results with regional antibody-guided irradiation. Cancer Drug Deliv 2:233 (abstract), 1985.

    Google Scholar 

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Authors
  1. James L. Murray
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  2. Lamk M. Lamki
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  3. Michael G. Rosenblum
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Editor information

Editors and Affiliations

  1. Winthrop-University Hospital, Mineola, New York, USA

    Larry Nathanson

  2. Department of Medicine, Health Science Center, SUNY, Stony Brook, New York, USA

    Larry Nathanson

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© 1988 Kluwer Academic Publishers, Boston

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Murray, J.L., Lamki, L.M., Rosenblum, M.G. (1988). Radioimmunoimaging of malignant melanoma with monoclonal antibodies. In: Nathanson, L. (eds) Malignant Melanoma: Biology, Diagnosis, and Therapy. Cancer Treatment and Research, vol 43. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1751-7_8

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