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The cytogenetics of human malignant melanoma and premalignant lesions

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Malignant Melanoma: Biology, Diagnosis, and Therapy

Part of the book series: Cancer Treatment and Research ((CTAR,volume 43))

Abstract

Although much has been published on the chromosomal changes seen in the leukemias and lymphomas, until recently there have been little data available on the cytogenetics of solid tumors. Most of the information that is available has been derived from far advanced lesions, often metastases, that may have been in tissue culture for long periods of time. These lesions usually contain many chromosomal changes, making it difficult to sort out what the primary or initial change might have been. When earlier lesions are available, they usually have had very few dividing cells and must be cultured for a period of time before the mitotic index is high enough to permit chromosomal studies. It is also difficult to routinely establish these lesions in culture. Even when culturing is successful, the chromosomes obtained from these preparations are often of poor quality, making it difficult to determine the specific chromosomal changes.

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Authors
  1. Annette H. Parmiter
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  2. Peter C. Nowell
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Editor information

Editors and Affiliations

  1. Winthrop-University Hospital, Mineola, New York, USA

    Larry Nathanson

  2. Department of Medicine, Health Science Center, SUNY, Stony Brook, New York, USA

    Larry Nathanson

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© 1988 Kluwer Academic Publishers, Boston

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Parmiter, A.H., Nowell, P.C. (1988). The cytogenetics of human malignant melanoma and premalignant lesions. In: Nathanson, L. (eds) Malignant Melanoma: Biology, Diagnosis, and Therapy. Cancer Treatment and Research, vol 43. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1751-7_3

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  • DOI: https://doi.org/10.1007/978-1-4613-1751-7_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8983-8

  • Online ISBN: 978-1-4613-1751-7

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