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Developmental failure in human reproduction associated with preovulatory oogenesis and preimplantation embryogenesis

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Ultrastructure of Human Gametogenesis and Early Embryogenesis

Part of the book series: Electron Microscopy in Biology and Medicine ((EMBM,volume 5))

Abstract

The rapid and worldwide application of in vitro fertilization (IVF) for the treatment of human infertility has presented the opportunity to examine, by noninvasive (1) and invasive protocols (2,3), molecular and cellular aspects of normal and abnormal oocyte and early embryonic development in large and clinically varied patient populations. The collective findings from thousands of attempts at IVF demonstrate that the vast majority of fertilized human eggs do not result in a pregnancy and that most embryos appear to arrest development during the pre-and early postimplantation stages of gestation (4,5).

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Authors and Affiliations

  1. Department of Molecular, Cellular and Development Biology, University of Colorado, Boulder, Colorado, USA

    Professor Jonathan Van Blerkom

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  1. Professor Jonathan Van Blerkom
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Editors and Affiliations

  1. Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado, USA

    Jonathan Van Blerkom Ph.D.

  2. Reproductive Genetics in Vitro, Denver, Colorado, USA

    Jonathan Van Blerkom Ph.D.

  3. Department of Anatomy, University of Rome, Rome, Italy

    Pietro M. Motta Ph.D., M.D.

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© 1989 Kluwer Academic Publishers, Boston

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Van Blerkom, J. (1989). Developmental failure in human reproduction associated with preovulatory oogenesis and preimplantation embryogenesis. In: Van Blerkom, J., Motta, P.M. (eds) Ultrastructure of Human Gametogenesis and Early Embryogenesis. Electron Microscopy in Biology and Medicine, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1749-4_5

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