Abstract
The 1980’s have witnessed a revolution in the approach to the treatment of patients with acute myocardial infarction. The publication by De Wood et al. (1) demonstrated the presence of obstructive coronary thrombi in 90% of patients who underwent coronary angiography within 4 hours of the onset of symptoms of acute myocardial infarction. The documentation of coronary thrombosis as a pivotal event in the pathophysiology of acute myocardial infarction provided the rationale for investigating pharmacologic and mechanical means of recanalizing acutely occluded coronary arteries. Subsequent studies documented that coronary arteries occluded by thrombus can be re-opened by thrombolytic agents or coronary angioplasty (2). Recent multicenter clinical trials showed that hospital mortality is reduced by the early administration of streptokinase to patients with acute myocardial infarction (3, 4). Thus, thrombolytic therapy is gaining increasing acceptance as the standard of care for the treatment of patients suspected of acute myocardial infarction.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
DeWood, M. A., Spores, J., Notske, R., Nouser, L. T., Burroughs, R., Golden, M. S. and Lang, H. T. N. Engl. J. Med. 203:897–902, 1980.
Smith, B. and Kennedy, J. W. Annals of Internal Med. 106:414–420, 1987.
Grupo Italiano per Io studio delia streptochinasi nell’ infarto miocardico (GISSI). The Lancet 22, February 1986.
ISIS Steering Committee. The Lancet. 28, February 1987.
Jennings, R. B. and Reimer, K. A. Circulation 68(Suppl. 1):I-25–I-36, 1983.
Rossen, R. D., Swain, J. L., Michael, L. H., Weakley, S., Giannini, E. and Entman, M. L. Circ. Res. 57:119–130. 1985.
Mullane, K. M., Kraemer, R. and Smith, B. J. Pharmacological Methods 14:157–167, 1985.
de Lorgeril, M., Rousseau, G., Basmadjian, A. and Latour, J-G. Fed. Proc. 46:1043, 1987.
Chatelain, P., Latour, J-G., Tran, D., de Lorgeril, M., Dupras, G. and Bourassa, M. Circulation 75:1083–1090, 1987.
Sommers, H. M. and Jennings, R. B. Lab. Invest. 13:1491–1503, 1964.
Friedman, B. J., Jay, M. and Gillespie, M.N. Circulation 74 (Supp II):II–348, 1986.
Hartmann, J. R., Robinson, J. A. and Gunnar, R. M. Am. J. Cardiol. 40:550–555,1977.
Rossen, R. D., Reisberg, M. A., Michael, L. H., Moake, J. N., Weakley, S., Giannini, E. and Entman, M. L. Fed. Proc. 45:940, 1986.
Berger, M. and Medof, E. J. Clin. Invest. 79:214–220, 1987.
Bevilacqua, M. P., Pober, J. S., Majeau, G. R., Cotran, R. S. and Gimbrone, M. A. J. Exp. Med. 160:618–623, 1984.
Bevilacqua, M. P., Pober, J. S., Wheeler, M. E., Cotran, R. S. and Gimbrone, M. A. Am. J. Pathol. 121:393–403, 1985.
Bevilacqua, M. P., Pober, J. S., Wheeler, M. E., Cotran, R. S. and Gimbrone, M. A. J. Clin. Invest. 76:2003–2011, 1985.
Schmid-Schonbein, G. W. and Engler, R. L. Am. J. Cardiovasc. Pathol. 1:15–30, 1986.
Arnaout, M. A., Dana, N., Pitt, J., and Todd, R. F. Fed. Proc. 44:2664–2670, 1985.
Springer, T. A. Fed. Proc. 44:2660–2663, 1985.
Anderson, D. C, Schamalsteig, F. C. and Shearer, W. Fed. Proc. 44:2671–2677, 1985.
Simon, R. H., DeHart, P. D. and Todd, R. F. J. Clin. Invest. 78:1375–1386,1986.
Berger, M., O’Shea, J. and Cross, A. S. J. Clin. Invest. 74:1566–1571, 1984.
Tonnesen, M. G., Smedly, L. A. and Henson, P. M. J. Clin. Invest. 74:1581–1592, 1984.
Fantone, J. C. and Ward, P. A. Am. J. Pathol. 107:397–418, 1982.
Weiss, S. J. and Lobuglio, A. F. Lab. Invest. 47:5–18, 1982.
Rowe, G. T., Manson, N. H., Caplan, M. and Hess, M. L. Circ. Res. 53:584–591, 1983.
Gillespie, M. N., Kojima, S., Kunitomo, M. and Jay, M. J. Pharmacol. Exp. Ther. 239:836–840, 1986.
Chambers, D. E., Parks, D. A., Patterson, G., Roy, R., McCord, J. M., Yoshida, S., Parmley, L. F. and Downey, J. M.J. Mol. Cell. Cardiol. 17:145–152, 1985.
Werns, S. W., Shea, M. J., Driscoll, E. M., Cohen, C, Abrams, G. D., Pitt, B. and Lucchesi, B. R. Circ. Res. 56:895–898, 1985.
Ambrosio, G., Becker, L C, Hutchins, G. M., Weisman, H. F. and Weisfeldt, M. L. Circulation 74:1424–1433, 1986.
Mitsos, S. E., Fantone, J. C., Gallagher, K. P., Waiden, K. M., Simpson, P. J., Abrams, G. D., Schork, M. A. and Lucchesi, B. R. J. Cardiovasc. Pharmacol. 8:978–988, 1986.
Mitsos, S. E., Askew, T. E., Fantone, J. C., Kunkel, S. L., Abrams, G. D., Schork, M. A. and Lucchesi, B. R. Circulation 73:1077–1086, 1986.
Harlan, J. M., Killen, P. D., Harker, L. A., Striker, G. E. and Wright, D. G. J. Clin. Invest. 68:1394–1403, 1981.
Harlan, J. M. Blood 65:513–525, 1985.
Ossanna, P. J., Test, S. T., Matheson, N. R., Regiani, S. and Weiss, S. J. J. Clin. Invest. 77:1939–1951, 1986.
Weiss, S. J., Peppin, G., Ortiz, X., Ragsdale, C, and Test, S. T. Science 227:747–749, 1985.
Cannon, R. O., Butany, J. W., McManus, B. M., Speir, E., Kravitz, A. B., Bolli, R. and Ferrans, V. J. Am. J. Cardiol. 52:390–395, 1983.
Bolli, R., Cannon, R. O., Speir, E., Goldstein, R. E., and Epstein, S. E. J. Am. Coll. Cardiol. 2: 671–680, 1983.
Bolli, R., Cannon, R. O., Speir, E., Goldstein, R. E., and Epstein, S. E. J. Am. Coll. Cardiol. 2: 681–688, 1983.
Apprill, P., Schmitz, J. M., Campbell, W. B., Tilton, G., Ashton, J., Raheja, S., Buja, L. M. and Willerson, J. T. Circulation 72:397–405, 1985.
Jackson, C. V., Schumacher, W. A., Kunkel, S. L., Driscoll, E. M. and Lucchesi, B. R. Circ. Res. 58:218–229, 1986.
Gay, J. C, Beckman, J. K., Zaboy, K. A. and Lukens, J. N. Blood 67:931–936, 1986.
Kenzora, J. L., Perez, J. E., Bergmann, S. R. and Lange, L. G. J. Clin. Invest. 74:1193–1203, 1984.
Sybertz, E. J., Watkins, R. W., Baum, T., Pula, K. and Rivelli, M. J. Pharmacol. Exp. Ther. 232:156–162, 1985.
Lewis, R. A. and Austen K. F. J. Clin. Invest. 73:889–897, 1984.
Michelassi, F., Castorena, G., Hill, R. D., Lowenstein, E., Watkins, W. D., Petkau, A. J. and Zapol W. M. Surgery 94:267–275, 1983.
Ford-Hutchinson, A. W. Fed. Proc. 44:25–29, 1985.
Gimbrone, M. A., Brock, A. F. and Schafer, A. I. J. Clin. Invest. 74:1552–1555, 1984.
Bednar, M., Smith, B., Pinto, A. and Mullane, K. M. Circ. Res. 57:131–141, 1985.
Romson, J. L, Hook, B. G., Kunkel, S. L, Abrams, G. D., Schork, M. A. and Lucchesi, B. R. Circulation 67:1016–1023, 1983.
Jolly, S. R., Kane, W. J., Hook, B. G., Abrams, G. D., Kunkel, S. L. and B. R. Lucchesi, S. L. Am. Heart J. 112:682–690, 1986.
Romson, J. L., Bush, L. R., Jolly, S. R. and Lucchesi, B. R. J. Cardiovasc. Pharmacol. 4:187–196, 1982.
Romson, J. L, Hook, B. G., Rigot, V. H., Schork, M. A., Swanson, D. P. and Lucchesi, B. R. Circulation 66:1002–1011, 1982.
Reimer, K. A., Jennings, R. B., Cobb, F. R., Murdock, R. H., Greenfield, J. C, Becker, L. C, Bulkley, B. H., Hutchins, G. M., Schwartz, R. P., Bailey, K. R. and Passamani E. R. Circ. Res. 56:651–665, 1985.
Gallagher, K. P., Buda, A. J., Pace, D., Gerren, R. A. and Shlafer, M. Circulation 73:1065–1076, 1986.
Braunwald, E. and Kloner, R. A. Circulation 66:1146–1149, 1982.
O’Neill, P. G., Charlat, M. L., Hartley, C. J., Michael, L. H., Roberts, R. and Bolli, R. Circulation 74(Supp II):II–349, 1986.
Shea, M. J., Simpson, P. J., Werns, S. W., Buda, A. J., Alborzy-Khaghany, A. S., Hoff, P. T., Pitt, B. and Luccchesi, B. R. Clin. Res. 35:327A, 1987.
Engler, R. and Covell, J. W. Circulation 74: (Suppl. II):II–373, 1986.
Myers, M. L, Bolli, R., Lekich, R. F., Hartley, C. J. and Roberts, R. Circulation 72:915–921, 1985.
Przyklenk, K. and Kloner, R. A. Circ. Res. 58:148–156, 1986.
Gross, G. J., Farber, N. E., Hardman, H. F. and Warltier, D. C. Am. J. Physiol. 250:H372–H377, 1986.
Bonow, R. O., Lipson, L. C, Sheehan, F. H., Capurrro, N. L, Isner, J. M., Roberts, W. C, Goldstein, R. E. and Epstein, S. E. Am. J. Cardiol. 47: 258–264, 1981.
Mullane, K. M. and McGiff, J.C. J. Cardiovasc. Pharmacol. 7:733–738, 1985.
Jolly, S. R., Schumacher, W. A., Kunkel, S. L., Abrams, G. D., Liddicoat, J. and Lucchesi, B. R. Basic Res. Cardiol. 80:269–279, 1985.
Flynn, P. J., Becker, W. K., Vercellotti, G. M., Weisdorf, D. J., Craddock, P. R., Hammerschmidt, D. E., Lillehei, R. C. and Jacob, H. S. Inflammation 8:33–44,1984.
Simpson, P. J., Mitsos, S. E., Ventura, A., Gallagher, K. P., Fantone, J. C, Abrams, G. D., Schork, M. A. and Lucchesi, B. R. Am. Heart J. 113: 129–137, 1987.
Simpson, P. J., Mickelson, J., Fantone, J. C, Gallagher, K. P. and Lucchesi, B. R. Circ. Res. 1987 (in press)
Simpson, P. J., Mickelson, J., Fantone, J. C, Gallagher, K. P. and Lucchesi, B. R. Fed. Proc. 46:1144, 1987.
Jugdutt, B. L, Hutchins, G. M., Bulkley, B. H. and Becker, L. C. Circ. Res. 49:685–700, 1981.
Melin, J. A., and Becker, L. C. J. Am. Coll. Cardiol. 2:279–286, 1983.
Jarasch, E-D., Bruder, G. and Heid H. W. Acta. Physiol. Scand., Suppl. 548:39–46. 1986.
Werns, S. W., Shea, M. J., Mitsos, S. E., Dysko, R. C, Fantone, J. C, Schork, M. A., Abrams, G. D., Pitt, B. and Lucchesi, B. R. Circulation 73:518–524, 1986.
Reimer, K. A. and Jennings, R. B. Circulation 71:1069–1075, 1985.
Werns, S. W., Ventura, A. and Lucchesi, B. R. Clin. Res. 35:334A, 1987.
Grum, C. M., Ketai, L H., Myers, C. L. and Shlafer, M. Am. J. Physiol. 252:H368–H373, 1987.
Myers, C. L, Weiss, S. J., Kirsh, M. M., Shepard, B. M. and Shlafer, M. J. Thorac. Cardiovasc. Surg. 91:281–289, 1986.
Grum, C. M., Ragsdale, R. A., Ketai, L. H. and Shlafer, M. Biochem. Biophys. Res. Comm. 141:1104–1108, 1986.
Moorhouse, P. C, Grootveld, M., Halliwell, B., Quinlan G. J. and Gutteridge, J. M. C. FEBS Lett 213:23–28, 1987.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Kluwer Academic Publishers
About this chapter
Cite this chapter
Werns, S.W., Lucchesi, B.R. (1988). The Role of the Polymorphonuclear Leukocyte in Mediating Myocardial Reperfusion Injury. In: Singal, P.K. (eds) Oxygen Radicals in the Pathophysiology of Heart Disease. Developments in Cardiovascular Medicine, vol 86. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1743-2_9
Download citation
DOI: https://doi.org/10.1007/978-1-4613-1743-2_9
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8979-1
Online ISBN: 978-1-4613-1743-2
eBook Packages: Springer Book Archive