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Oxygen Radicals in the Pathophysiology of Heart Disease pp 123–144Cite as

The Role of the Polymorphonuclear Leukocyte in Mediating Myocardial Reperfusion Injury

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Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 86))

Abstract

The 1980’s have witnessed a revolution in the approach to the treatment of patients with acute myocardial infarction. The publication by De Wood et al. (1) demonstrated the presence of obstructive coronary thrombi in 90% of patients who underwent coronary angiography within 4 hours of the onset of symptoms of acute myocardial infarction. The documentation of coronary thrombosis as a pivotal event in the pathophysiology of acute myocardial infarction provided the rationale for investigating pharmacologic and mechanical means of recanalizing acutely occluded coronary arteries. Subsequent studies documented that coronary arteries occluded by thrombus can be re-opened by thrombolytic agents or coronary angioplasty (2). Recent multicenter clinical trials showed that hospital mortality is reduced by the early administration of streptokinase to patients with acute myocardial infarction (3, 4). Thus, thrombolytic therapy is gaining increasing acceptance as the standard of care for the treatment of patients suspected of acute myocardial infarction.

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References

  1. DeWood, M. A., Spores, J., Notske, R., Nouser, L. T., Burroughs, R., Golden, M. S. and Lang, H. T. N. Engl. J. Med. 203:897–902, 1980.

    Article  Google Scholar 

  2. Smith, B. and Kennedy, J. W. Annals of Internal Med. 106:414–420, 1987.

    Article  CAS  Google Scholar 

  3. Grupo Italiano per Io studio delia streptochinasi nell’ infarto miocardico (GISSI). The Lancet 22, February 1986.

    Google Scholar 

  4. ISIS Steering Committee. The Lancet. 28, February 1987.

    Google Scholar 

  5. Jennings, R. B. and Reimer, K. A. Circulation 68(Suppl. 1):I-25–I-36, 1983.

    Google Scholar 

  6. Rossen, R. D., Swain, J. L., Michael, L. H., Weakley, S., Giannini, E. and Entman, M. L. Circ. Res. 57:119–130. 1985.

    Article  CAS  Google Scholar 

  7. Mullane, K. M., Kraemer, R. and Smith, B. J. Pharmacological Methods 14:157–167, 1985.

    Article  CAS  Google Scholar 

  8. de Lorgeril, M., Rousseau, G., Basmadjian, A. and Latour, J-G. Fed. Proc. 46:1043, 1987.

    Google Scholar 

  9. Chatelain, P., Latour, J-G., Tran, D., de Lorgeril, M., Dupras, G. and Bourassa, M. Circulation 75:1083–1090, 1987.

    Article  PubMed  CAS  Google Scholar 

  10. Sommers, H. M. and Jennings, R. B. Lab. Invest. 13:1491–1503, 1964.

    PubMed  CAS  Google Scholar 

  11. Friedman, B. J., Jay, M. and Gillespie, M.N. Circulation 74 (Supp II):II–348, 1986.

    Google Scholar 

  12. Hartmann, J. R., Robinson, J. A. and Gunnar, R. M. Am. J. Cardiol. 40:550–555,1977.

    Article  PubMed  CAS  Google Scholar 

  13. Rossen, R. D., Reisberg, M. A., Michael, L. H., Moake, J. N., Weakley, S., Giannini, E. and Entman, M. L. Fed. Proc. 45:940, 1986.

    Google Scholar 

  14. Berger, M. and Medof, E. J. Clin. Invest. 79:214–220, 1987.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  15. Bevilacqua, M. P., Pober, J. S., Majeau, G. R., Cotran, R. S. and Gimbrone, M. A. J. Exp. Med. 160:618–623, 1984.

    Article  PubMed  CAS  Google Scholar 

  16. Bevilacqua, M. P., Pober, J. S., Wheeler, M. E., Cotran, R. S. and Gimbrone, M. A. Am. J. Pathol. 121:393–403, 1985.

    Google Scholar 

  17. Bevilacqua, M. P., Pober, J. S., Wheeler, M. E., Cotran, R. S. and Gimbrone, M. A. J. Clin. Invest. 76:2003–2011, 1985.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  18. Schmid-Schonbein, G. W. and Engler, R. L. Am. J. Cardiovasc. Pathol. 1:15–30, 1986.

    Google Scholar 

  19. Arnaout, M. A., Dana, N., Pitt, J., and Todd, R. F. Fed. Proc. 44:2664–2670, 1985.

    PubMed  CAS  Google Scholar 

  20. Springer, T. A. Fed. Proc. 44:2660–2663, 1985.

    PubMed  CAS  Google Scholar 

  21. Anderson, D. C, Schamalsteig, F. C. and Shearer, W. Fed. Proc. 44:2671–2677, 1985.

    PubMed  CAS  Google Scholar 

  22. Simon, R. H., DeHart, P. D. and Todd, R. F. J. Clin. Invest. 78:1375–1386,1986.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  23. Berger, M., O’Shea, J. and Cross, A. S. J. Clin. Invest. 74:1566–1571, 1984.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  24. Tonnesen, M. G., Smedly, L. A. and Henson, P. M. J. Clin. Invest. 74:1581–1592, 1984.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  25. Fantone, J. C. and Ward, P. A. Am. J. Pathol. 107:397–418, 1982.

    CAS  Google Scholar 

  26. Weiss, S. J. and Lobuglio, A. F. Lab. Invest. 47:5–18, 1982.

    PubMed  CAS  Google Scholar 

  27. Rowe, G. T., Manson, N. H., Caplan, M. and Hess, M. L. Circ. Res. 53:584–591, 1983.

    Article  PubMed  CAS  Google Scholar 

  28. Gillespie, M. N., Kojima, S., Kunitomo, M. and Jay, M. J. Pharmacol. Exp. Ther. 239:836–840, 1986.

    PubMed  CAS  Google Scholar 

  29. Chambers, D. E., Parks, D. A., Patterson, G., Roy, R., McCord, J. M., Yoshida, S., Parmley, L. F. and Downey, J. M.J. Mol. Cell. Cardiol. 17:145–152, 1985.

    Article  PubMed  CAS  Google Scholar 

  30. Werns, S. W., Shea, M. J., Driscoll, E. M., Cohen, C, Abrams, G. D., Pitt, B. and Lucchesi, B. R. Circ. Res. 56:895–898, 1985.

    Article  PubMed  CAS  Google Scholar 

  31. Ambrosio, G., Becker, L C, Hutchins, G. M., Weisman, H. F. and Weisfeldt, M. L. Circulation 74:1424–1433, 1986.

    Article  PubMed  CAS  Google Scholar 

  32. Mitsos, S. E., Fantone, J. C., Gallagher, K. P., Waiden, K. M., Simpson, P. J., Abrams, G. D., Schork, M. A. and Lucchesi, B. R. J. Cardiovasc. Pharmacol. 8:978–988, 1986.

    Article  PubMed  CAS  Google Scholar 

  33. Mitsos, S. E., Askew, T. E., Fantone, J. C., Kunkel, S. L., Abrams, G. D., Schork, M. A. and Lucchesi, B. R. Circulation 73:1077–1086, 1986.

    Article  PubMed  CAS  Google Scholar 

  34. Harlan, J. M., Killen, P. D., Harker, L. A., Striker, G. E. and Wright, D. G. J. Clin. Invest. 68:1394–1403, 1981.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  35. Harlan, J. M. Blood 65:513–525, 1985.

    PubMed  CAS  Google Scholar 

  36. Ossanna, P. J., Test, S. T., Matheson, N. R., Regiani, S. and Weiss, S. J. J. Clin. Invest. 77:1939–1951, 1986.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  37. Weiss, S. J., Peppin, G., Ortiz, X., Ragsdale, C, and Test, S. T. Science 227:747–749, 1985.

    Article  PubMed  CAS  Google Scholar 

  38. Cannon, R. O., Butany, J. W., McManus, B. M., Speir, E., Kravitz, A. B., Bolli, R. and Ferrans, V. J. Am. J. Cardiol. 52:390–395, 1983.

    Article  PubMed  CAS  Google Scholar 

  39. Bolli, R., Cannon, R. O., Speir, E., Goldstein, R. E., and Epstein, S. E. J. Am. Coll. Cardiol. 2: 671–680, 1983.

    Article  PubMed  CAS  Google Scholar 

  40. Bolli, R., Cannon, R. O., Speir, E., Goldstein, R. E., and Epstein, S. E. J. Am. Coll. Cardiol. 2: 681–688, 1983.

    Article  PubMed  CAS  Google Scholar 

  41. Apprill, P., Schmitz, J. M., Campbell, W. B., Tilton, G., Ashton, J., Raheja, S., Buja, L. M. and Willerson, J. T. Circulation 72:397–405, 1985.

    Article  PubMed  CAS  Google Scholar 

  42. Jackson, C. V., Schumacher, W. A., Kunkel, S. L., Driscoll, E. M. and Lucchesi, B. R. Circ. Res. 58:218–229, 1986.

    Article  PubMed  CAS  Google Scholar 

  43. Gay, J. C, Beckman, J. K., Zaboy, K. A. and Lukens, J. N. Blood 67:931–936, 1986.

    PubMed  CAS  Google Scholar 

  44. Kenzora, J. L., Perez, J. E., Bergmann, S. R. and Lange, L. G. J. Clin. Invest. 74:1193–1203, 1984.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  45. Sybertz, E. J., Watkins, R. W., Baum, T., Pula, K. and Rivelli, M. J. Pharmacol. Exp. Ther. 232:156–162, 1985.

    PubMed  CAS  Google Scholar 

  46. Lewis, R. A. and Austen K. F. J. Clin. Invest. 73:889–897, 1984.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  47. Michelassi, F., Castorena, G., Hill, R. D., Lowenstein, E., Watkins, W. D., Petkau, A. J. and Zapol W. M. Surgery 94:267–275, 1983.

    PubMed  CAS  Google Scholar 

  48. Ford-Hutchinson, A. W. Fed. Proc. 44:25–29, 1985.

    PubMed  CAS  Google Scholar 

  49. Gimbrone, M. A., Brock, A. F. and Schafer, A. I. J. Clin. Invest. 74:1552–1555, 1984.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  50. Bednar, M., Smith, B., Pinto, A. and Mullane, K. M. Circ. Res. 57:131–141, 1985.

    Article  PubMed  CAS  Google Scholar 

  51. Romson, J. L, Hook, B. G., Kunkel, S. L, Abrams, G. D., Schork, M. A. and Lucchesi, B. R. Circulation 67:1016–1023, 1983.

    Article  PubMed  CAS  Google Scholar 

  52. Jolly, S. R., Kane, W. J., Hook, B. G., Abrams, G. D., Kunkel, S. L. and B. R. Lucchesi, S. L. Am. Heart J. 112:682–690, 1986.

    Article  CAS  Google Scholar 

  53. Romson, J. L., Bush, L. R., Jolly, S. R. and Lucchesi, B. R. J. Cardiovasc. Pharmacol. 4:187–196, 1982.

    Article  PubMed  CAS  Google Scholar 

  54. Romson, J. L, Hook, B. G., Rigot, V. H., Schork, M. A., Swanson, D. P. and Lucchesi, B. R. Circulation 66:1002–1011, 1982.

    Article  PubMed  CAS  Google Scholar 

  55. Reimer, K. A., Jennings, R. B., Cobb, F. R., Murdock, R. H., Greenfield, J. C, Becker, L. C, Bulkley, B. H., Hutchins, G. M., Schwartz, R. P., Bailey, K. R. and Passamani E. R. Circ. Res. 56:651–665, 1985.

    Article  PubMed  CAS  Google Scholar 

  56. Gallagher, K. P., Buda, A. J., Pace, D., Gerren, R. A. and Shlafer, M. Circulation 73:1065–1076, 1986.

    Article  PubMed  CAS  Google Scholar 

  57. Braunwald, E. and Kloner, R. A. Circulation 66:1146–1149, 1982.

    Article  PubMed  CAS  Google Scholar 

  58. O’Neill, P. G., Charlat, M. L., Hartley, C. J., Michael, L. H., Roberts, R. and Bolli, R. Circulation 74(Supp II):II–349, 1986.

    Google Scholar 

  59. Shea, M. J., Simpson, P. J., Werns, S. W., Buda, A. J., Alborzy-Khaghany, A. S., Hoff, P. T., Pitt, B. and Luccchesi, B. R. Clin. Res. 35:327A, 1987.

    Google Scholar 

  60. Engler, R. and Covell, J. W. Circulation 74: (Suppl. II):II–373, 1986.

    Google Scholar 

  61. Myers, M. L, Bolli, R., Lekich, R. F., Hartley, C. J. and Roberts, R. Circulation 72:915–921, 1985.

    Article  PubMed  CAS  Google Scholar 

  62. Przyklenk, K. and Kloner, R. A. Circ. Res. 58:148–156, 1986.

    Article  PubMed  CAS  Google Scholar 

  63. Gross, G. J., Farber, N. E., Hardman, H. F. and Warltier, D. C. Am. J. Physiol. 250:H372–H377, 1986.

    PubMed  CAS  Google Scholar 

  64. Bonow, R. O., Lipson, L. C, Sheehan, F. H., Capurrro, N. L, Isner, J. M., Roberts, W. C, Goldstein, R. E. and Epstein, S. E. Am. J. Cardiol. 47: 258–264, 1981.

    Article  PubMed  CAS  Google Scholar 

  65. Mullane, K. M. and McGiff, J.C. J. Cardiovasc. Pharmacol. 7:733–738, 1985.

    Article  PubMed  CAS  Google Scholar 

  66. Jolly, S. R., Schumacher, W. A., Kunkel, S. L., Abrams, G. D., Liddicoat, J. and Lucchesi, B. R. Basic Res. Cardiol. 80:269–279, 1985.

    Article  PubMed  CAS  Google Scholar 

  67. Flynn, P. J., Becker, W. K., Vercellotti, G. M., Weisdorf, D. J., Craddock, P. R., Hammerschmidt, D. E., Lillehei, R. C. and Jacob, H. S. Inflammation 8:33–44,1984.

    Article  PubMed  CAS  Google Scholar 

  68. Simpson, P. J., Mitsos, S. E., Ventura, A., Gallagher, K. P., Fantone, J. C, Abrams, G. D., Schork, M. A. and Lucchesi, B. R. Am. Heart J. 113: 129–137, 1987.

    Article  PubMed  CAS  Google Scholar 

  69. Simpson, P. J., Mickelson, J., Fantone, J. C, Gallagher, K. P. and Lucchesi, B. R. Circ. Res. 1987 (in press)

    Google Scholar 

  70. Simpson, P. J., Mickelson, J., Fantone, J. C, Gallagher, K. P. and Lucchesi, B. R. Fed. Proc. 46:1144, 1987.

    Google Scholar 

  71. Jugdutt, B. L, Hutchins, G. M., Bulkley, B. H. and Becker, L. C. Circ. Res. 49:685–700, 1981.

    Article  PubMed  CAS  Google Scholar 

  72. Melin, J. A., and Becker, L. C. J. Am. Coll. Cardiol. 2:279–286, 1983.

    Article  CAS  Google Scholar 

  73. Jarasch, E-D., Bruder, G. and Heid H. W. Acta. Physiol. Scand., Suppl. 548:39–46. 1986.

    CAS  Google Scholar 

  74. Werns, S. W., Shea, M. J., Mitsos, S. E., Dysko, R. C, Fantone, J. C, Schork, M. A., Abrams, G. D., Pitt, B. and Lucchesi, B. R. Circulation 73:518–524, 1986.

    Article  PubMed  CAS  Google Scholar 

  75. Reimer, K. A. and Jennings, R. B. Circulation 71:1069–1075, 1985.

    Article  PubMed  CAS  Google Scholar 

  76. Werns, S. W., Ventura, A. and Lucchesi, B. R. Clin. Res. 35:334A, 1987.

    Google Scholar 

  77. Grum, C. M., Ketai, L H., Myers, C. L. and Shlafer, M. Am. J. Physiol. 252:H368–H373, 1987.

    PubMed  CAS  Google Scholar 

  78. Myers, C. L, Weiss, S. J., Kirsh, M. M., Shepard, B. M. and Shlafer, M. J. Thorac. Cardiovasc. Surg. 91:281–289, 1986.

    CAS  Google Scholar 

  79. Grum, C. M., Ragsdale, R. A., Ketai, L. H. and Shlafer, M. Biochem. Biophys. Res. Comm. 141:1104–1108, 1986.

    Article  PubMed  CAS  Google Scholar 

  80. Moorhouse, P. C, Grootveld, M., Halliwell, B., Quinlan G. J. and Gutteridge, J. M. C. FEBS Lett 213:23–28, 1987.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Internal Medicine, Division of Cardiology, Taubman Medical Center, University of Michigan Medical School, Room 3910K, Ann Arbor, Michigan, 48109, USA

    Steven W. Werns M.D.

  2. Department of Pharmacology, Medical Science, University of Michigan Medical School, Building I, M6322, Ann Arbor, Michigan, 48109, USA

    Benedict R. Lucchesi Ph.D., M.D.

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  1. Steven W. Werns M.D.
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  2. Benedict R. Lucchesi Ph.D., M.D.
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Editor information

Editors and Affiliations

  1. Division of Cardiovascular Sciences, St. Boniface General Hospital Research Center, Winnipeg, Manitoba, R3E 0W3, Canada

    Pawan K. Singal

  2. Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, R3E 0W3, Canada

    Pawan K. Singal

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© 1988 Kluwer Academic Publishers

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Werns, S.W., Lucchesi, B.R. (1988). The Role of the Polymorphonuclear Leukocyte in Mediating Myocardial Reperfusion Injury. In: Singal, P.K. (eds) Oxygen Radicals in the Pathophysiology of Heart Disease. Developments in Cardiovascular Medicine, vol 86. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1743-2_9

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  • DOI: https://doi.org/10.1007/978-1-4613-1743-2_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8979-1

  • Online ISBN: 978-1-4613-1743-2

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