The Role of Oxygen Free Radicals during the Course of Myocardial Ischemia/Reperfusion Injury: An Analysis and Critique

  • M. L. Hess
  • T. D. Greenfield
  • N. H. Manson
  • Eiichiro Okabe
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 86)

Abstract

Myocardial ischemia results in a series of metabolic events that include the autooxidation of catecholamines, a reduction in intracellular pH, the breakdown of ATP to hypoxanthine and xanthine, an increase in reducing equivalents and activation of the cyclooxygenase system. All of these reactions favor the univalent reduction of molecular oxygen to free oxygen radicals and their metabolites (superoxide anion, ·O2 -, hydrogen peroxide, H2O2, and the hydroxyl radical, ·OH) (1,2). These metabolites of molecular oxygen are highly toxic and are capable of extensive tissue damage. With reperfusion and reintroduction of molecular oxygen into this previously ischemic vascular bed, the myocardium is then “primed” for the production of a “burst” of oxygen intermediates and further extensive tissue damage (3).

Keywords

Ischemia Superoxide Catalase Catecholamine Cardiol 

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References

  1. 1.
    Okabe, E., Tanake, K. and Ito, H. Free Rad. Clin. Med. 1:31–41, 1987.Google Scholar
  2. 2.
    Thompson, J.A. and Hess, M.L. Prog. Cardiovasc. Dis. 18:449–462, 1986.CrossRefGoogle Scholar
  3. 3.
    Hess, M.L. and Manson, N.H. J. Mol. Cell. Cardiol. 16:968–985, 1984.CrossRefGoogle Scholar
  4. 4.
    Krause, S.M. and Hess, M.L. Circ. Res. 55:176–184, 1984.PubMedCrossRefGoogle Scholar
  5. 5.
    Franson, R., Gamache, D., Blackwell, W., Eisen, D. and Hess, M.L. Am. J. Physiol. 251: H1017–H1023, 1986.PubMedGoogle Scholar
  6. 6.
    Stewart, J.R., Blackwell, W.H., Crute, S.L., Loughlin, V., Greenfield, L.J., Hess, M.L. and J. Thorac. Cardiovas. Surg. 86:262–272, 1983.Google Scholar
  7. 7.
    Engler, R. Federation Proc. 46:2395–2397, 1987.Google Scholar
  8. 8.
    Hearse, D.S., Manning, A.S., Downey, J.M. and Yellon, D.M. Acta. Physiol. Scand. 126:65–78, 1986.Google Scholar
  9. 9.
    Hammond, B., Kontos, H.A. and Hess, M.L. Can. J. Physiol. 63:173–193, 1985.CrossRefGoogle Scholar
  10. 10.
    Rao, P.S. and Mueller, H.S. In: Adv.Exp. Med. Biol. (ed. Sptizer, J.J.), Plenum Press, New York, 1983, p.347–364.Google Scholar
  11. 11.
    Werns, S.W., Shea, M.J., Driscoll, E.M., Cohen, C, Abrams, G.D., Pitt, B. and Lucchesi, B.R. Circ. Res. 56:895–898, 1985.PubMedCrossRefGoogle Scholar
  12. 12.
    Hess, M.L., Manson, N.H. and Stewart, J.R. In: Myocardial Protection in Cardiac Surgery (ed. Roberts, A.J.) Marcel Dekker, Inc., New York, 1987, p. 451–461.Google Scholar
  13. 13.
    Bolli, R., Wei-Xi, Zhu, Hartley, C.J., Machael, L.J., Hess, M.L., Kukreja, R.C. and Roberts, R. Circulation, In. Press, 1987.Google Scholar
  14. 14.
    Meyers, M.L., Bolli, R., Lekich, R.F., Hartley, C.J. and Roberts, R. Circulation 72:915–921, 1985.CrossRefGoogle Scholar
  15. 15.
    McCord, J.M. Federation Proc. 46:2402–2406, 1987.Google Scholar
  16. 16.
    Hess, M.L., Okabe, E., Ash, D. and Kontos, H.A. Cardiovas. Res. 18:149–157, 1984.CrossRefGoogle Scholar
  17. 17.
    Downey, J.M. Can. Fed. Biol. Soc. 72, 1987.Google Scholar
  18. 18.
    Simpson, P.S., Mickelson, J.K. and Lucchesi, B.R. Federation Proc. 46:2413–2421, 1987.Google Scholar
  19. 19.
    Romson, J.L., Hook, B.G., Kunkel, S.L., Abrams, G.P., Shork, M.A. and Lucchesi, B.R. Circulation 67:1016–1023, 1987.CrossRefGoogle Scholar
  20. 20.
    Kontos, H.A., Wei, E.P., Ellis, E.F., Jenkins, L.W., Povlishock, J.T., Rowe, G.T. and Hess, M.L. Circ. Res. 57:142–151, 1985.PubMedCrossRefGoogle Scholar
  21. 21.
    Reimer, K.A. and Jennings, R.B. Circulation 71:1069–1075, 1985.PubMedCrossRefGoogle Scholar
  22. 22.
    Uraizee, A., Reimer, K.A., Murry, C.E. and Jennings, R.B. Circulation 75:1237–1248, 1987.PubMedCrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1988

Authors and Affiliations

  • M. L. Hess
    • 1
  • T. D. Greenfield
    • 2
  • N. H. Manson
    • 1
  • Eiichiro Okabe
    • 3
  1. 1.Department of Medicine, Division of CardiologyMedical College of VirginiaRichmondUSA
  2. 2.The Department of SurgeryMedical College of VirginiaRichmondUSA
  3. 3.The Department of PharmacologyKanagawa Dental CollegeYosukaJapan

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