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Oxygen Radical Mediated Protein Oxidation in Heart

  • H. Fliss
  • M. Masika
  • D. W. Eley
  • B. Korecky
Chapter
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 86)

Abstract

The role played by reactive oxygen species in cardiac pathophysiology is presently an area of intense scientific interest. Reperfusion of ischemic myocardium (1), drug metabolism (2), cardiac surgery (3,4), and metabolism of catecholamines (5,6), are all known to produce oxygen free radicals (OFR) and other oxidants capable of effecting pathologies in the heart. A detailed description of the mechanisms of OFR production in these processes is beyond the scope of this chapter. However, they all involve the initial production of superoxide free radical (O 2 - ·). For example, the metabolism of quinone-containing drugs such as adriamycin and daunorubicin (7), is known to produce this oxidant, as is the metabolism of xanthine in ischemic myocardium (8). Superoxide can be reduced further to other reactive oxygen metabolites. The dismutation of superoxide by superoxide dismutase produces hydrogen peroxide (H2O2) which, in the presence of metal catalysts, can form the hydroxyl free radical (OH·) by the Fenton, or Haber-Weiss pathways (9).

Keywords

Sarcoplasmic Reticulum Papillary Muscle Spontaneous Recovery Negative Inotropic Effect Hypochlorous Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 1988

Authors and Affiliations

  • H. Fliss
    • 1
  • M. Masika
    • 1
  • D. W. Eley
    • 1
  • B. Korecky
    • 1
  1. 1.Dept. of Physiology, Faculty of Health SciencesUniversity of OttawaOttawaUSA

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