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Contributions of Leukocytes to Vascular Injury and Thrombosis

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Book cover Oxygen Radicals in the Pathophysiology of Heart Disease

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 86))

Abstract

Naturally occuring coronary reperfusion or reperfusion following treatment with fibrinolytic agents and/or percutaneous transluminal angioplasty can limit the extent of myocardial damage in patients with acute myocardial infarction (1–3). However, there are some undesirable sequelae of reperfusion which may limit its beneficial effects. One of these undesirable events is the acceleration of the acute inflammatory reaction observed in the early course of myocardial infarction (4–6). The contribution of the leukocytes which accumulate during this inflammatory response to myocardial damage and expansion of the infarct zone has been described (7,8). However, less attention has been directed to the early adherence of leukocytes to the vascular endothelium of the coronary vessels within the ischemic area. Accumulation of activated leukocytes on vascular endothelium could lead to several undesirable consequences relative to reflow to the ischemic area. These include physical obstruction of small vessels by leukocyte aggregates and thrombosis of both large and small vessels by direct endothelial cell injury or the generation of procoagulant substances (9–11). This paper will review the mechanisms by which PMN’s can initiate thrombosis of blood vessels at or near sites of tissue injury.

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Author information

Authors and Affiliations

  1. Atherosclerosis and Thrombosis Research and Hypersensitivity Diseases Research, The Upjohn Company, Kalamazoo, MI, 49001, USA

    R. G. Schaub, C. J. Dunn & C. Orlandi

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  1. R. G. Schaub
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  2. C. J. Dunn
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  3. C. Orlandi
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Editor information

Editors and Affiliations

  1. Division of Cardiovascular Sciences, St. Boniface General Hospital Research Center, Winnipeg, Manitoba, R3E 0W3, Canada

    Pawan K. Singal

  2. Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, R3E 0W3, Canada

    Pawan K. Singal

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© 1988 Kluwer Academic Publishers

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Schaub, R.G., Dunn, C.J., Orlandi, C. (1988). Contributions of Leukocytes to Vascular Injury and Thrombosis. In: Singal, P.K. (eds) Oxygen Radicals in the Pathophysiology of Heart Disease. Developments in Cardiovascular Medicine, vol 86. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1743-2_22

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  • DOI: https://doi.org/10.1007/978-1-4613-1743-2_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8979-1

  • Online ISBN: 978-1-4613-1743-2

  • eBook Packages: Springer Book Archive

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