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Reactive Oxygen Radical Processes in Diabetes

  • David V. Godin
  • Saleh A. Wohaieb
Chapter
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 86)

Abstract

Although the introduction of insulin therapy has revolutionized the management of patients with diabetes and has greatly reduced the incidence of mortality from the acute complications of the disease (such as ketoacidosis), the increased longevity of diabetic patients has led to the emergence of the serious and debilitating complications in these individuals (1, 2). Although efforts to control blood sugar levels are the primary focus of pharmacological and dietary measures presently employed in the management of diabetic patients, the relationship between the degree of diabetic control so achieved and the development of certain complications of chronic diabetes is a far from straightforward one, which remains to be clearly delineated. It is apparent, however, that secondary diabetic complications remain a major problem, despite currently available interventions aimed at maintaining relatively normal blood glucose levels (3). Indeed, some have reported that strict control may even be associated with an acceleration of deterioration, as in the case of microangiopathy affecting renal glomeruli and the retina (4, 5, 6).

Keywords

Diabetic Animal Plasma Insulin Level Haematological Alteration Diabetogenic Action Myocardial Ischaemic Injury 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 1988

Authors and Affiliations

  • David V. Godin
    • 1
  • Saleh A. Wohaieb
    • 1
  1. 1.Department of Pharmacology & Therapeutics, Faculty of MedicineThe University of British ColumbiaVancouverCanada

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