Importance of Electron Transfer through Allopurinol in Protection from Reperfusion Injury
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With the advent of organ transplantation and clinical intervention in ischemic states, the role of tissue reperfusion has assumed increasing importance. The pathological changes which can accompany reperfusion have been the focus of increasing interest. While the etiology of these changes is multifactorial, evidence has arisen from several laboratories that reduced oxygen species are involved. There are several intracellular sources which could produce reduced oxygen radicals, including prostaglandin synthetase, the cytochrome p450 system, the electron transport chain and xanthine oxidase. Because of the effectiveness of inhibitors of xanthine oxidase in blunting reperfusion damage in several organ systems, it has been postulated as a major source of these radicals. However, other interpretations could be drawn from this data. Using the heart as a focus of discussion, we shall study another possible effect of the most widely used xanthine oxidase inhibitor, allopurinol.
KeywordsInfarct Size Electron Transport Chain Xanthine Oxidase Electron Transport System Xanthine Oxidase Inhibitor
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