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Oxygen Radicals in the Pathophysiology of Heart Disease pp 227–237Cite as

Acute Effects of Antioxidants on in Vivo Models of Experimental Myocardial Ischemia and Infarction

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Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 86))

Abstract

It is well appreciated that early reperfusion of an occluded coronary artery can salvage at least some of the previously ischemic myocardium and thereby reduce the extent of ischemia-induced myocyte injury (1–3). However, it has more recently been suggested that reperfusion is a ‘double-edged sword’ (4): that is, restoration of blood flow may salvage some previously ischemic tissue, yet have deleterious effects on other previously ischemic myocytes.

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Author information

Authors and Affiliations

  1. Department of Internal Medicine, Division of Cardiology, Wayne State University and Harper Hospital, Detroit, MI, USA

    Karin Przyklenk Ph.D. & Robert A. Kloner M.D., Ph.D.

Authors
  1. Karin Przyklenk Ph.D.
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  2. Robert A. Kloner M.D., Ph.D.
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Editor information

Editors and Affiliations

  1. Division of Cardiovascular Sciences, St. Boniface General Hospital Research Center, Winnipeg, Manitoba, R3E 0W3, Canada

    Pawan K. Singal

  2. Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, R3E 0W3, Canada

    Pawan K. Singal

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© 1988 Kluwer Academic Publishers

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Przyklenk, K., Kloner, R.A. (1988). Acute Effects of Antioxidants on in Vivo Models of Experimental Myocardial Ischemia and Infarction. In: Singal, P.K. (eds) Oxygen Radicals in the Pathophysiology of Heart Disease. Developments in Cardiovascular Medicine, vol 86. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1743-2_15

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  • DOI: https://doi.org/10.1007/978-1-4613-1743-2_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8979-1

  • Online ISBN: 978-1-4613-1743-2

  • eBook Packages: Springer Book Archive

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