Acute Effects of Antioxidants on in Vivo Models of Experimental Myocardial Ischemia and Infarction

  • Karin Przyklenk
  • Robert A. Kloner
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 86)


It is well appreciated that early reperfusion of an occluded coronary artery can salvage at least some of the previously ischemic myocardium and thereby reduce the extent of ischemia-induced myocyte injury (1–3). However, it has more recently been suggested that reperfusion is a ‘double-edged sword’ (4): that is, restoration of blood flow may salvage some previously ischemic tissue, yet have deleterious effects on other previously ischemic myocytes.


Infarct Size Left Anterior Descend Coronary Occlusion Ischemic Tissue Coronary Artery Occlusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Kluwer Academic Publishers 1988

Authors and Affiliations

  • Karin Przyklenk
    • 1
  • Robert A. Kloner
    • 1
  1. 1.Department of Internal Medicine, Division of CardiologyWayne State University and Harper HospitalDetroitUSA

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