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Role of Oxy-Radicals in Postischemic Myocardial Dysfunction

  • Roberto Bolli
  • Robert Roberts
Chapter
  • 44 Downloads
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 86)

Abstract

Coronary artery reperfusion by means of thrombolytic therapy, percutaneous transluminal angioplasty, or bypass surgery is rapidly emerging as the fundamental strategy in the management of acute ischemic syndromes in patients with coronary artery disease. The explosive growth of interventional recanalization, coupled with the widespread recognition that spontaneous reperfusion occurs commonly following coronary artery spasm or thrombosis, has provided the impetus to investigate the consequences of restoring blood flow to the ischemic myocardium. Experimental studies have demonstrated that although early reperfusion limits infarct size, this beneficial effect does not lead to immediate functional improvement; rather, the return of contractility in tissue salvaged by reperfusion is delayed for hours, days or even weeks (1–9), a phenomenon that has been termed “stunned myocardium” (10).

Keywords

Electron Spin Resonance Sarcoplasmic Reticulum Xanthine Oxidase Coronary Occlusion Reduce Infarct Size 
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Copyright information

© Kluwer Academic Publishers 1988

Authors and Affiliations

  • Roberto Bolli
    • 1
  • Robert Roberts
    • 1
  1. 1.Experimental Animal Laboratory, Section of Cardiology, Department of MedicineBaylor College of MedicineHoustonUSA

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