Alterations in Membrane Phospholipids, Mechanisms of Free Radical Damage and Antioxidant Protection during Myocardial Ischemia and Reperfusion

  • Karen P. Burton
  • Kenneth D. Massey
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 86)


The mechanisms involved in cell damage during ischemia and the progression of damage observed during reperfusion are not completely understood. However, it has become apparent that a major alteration in the integrity of cell membranes may be a critical event in the evolution of ischemic damage from a reversible to an irreversible condition. Several mechanisms capable of altering membrane biochemistry have been examined for their role in initiating irreversible injury including oxygen-derived free radical reactions and activation of phospholipases. This chapter will review membrane phospholipid alterations observed during myocardial ischemia and reperfusion, and possible interventions aimed at attenuating phospholipid degradation. The role of free radical-mediated myocardial damage also will be reviewed. Free radicals have the potential to initiate peroxidation of membrane phospholipids and may cause extensive membrane damage contributing to the development of irreversible myocardial injury.


Lipid Peroxidation Xanthine Oxidase High Pressure Liquid Chromatography Membrane Phospholipid Total Phospholipid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Kluwer Academic Publishers, Boston/Dordrecht/Lancaster 1988

Authors and Affiliations

  • Karen P. Burton
    • 1
  • Kenneth D. Massey
    • 1
  1. 1.Department of PhysiologyUniversity of Texas Health Science CenterDallasUSA

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