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Alterations of Glutathione Status during Myocardial Ischaemia and Reperfusion

  • R. Ferrari
  • S. Curello
  • C. Ceconi
  • A. Cargnoni
  • E. Condorelli
  • A. Albertini
Chapter
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 86)

Abstract

Glutathione is a physiologically important tripeptide with the sequence γ-glutamylcysteineinylglycine (1). This ubiquitous molecule is the most abundant cellular oligopeptide with a thiol group. Glutathione, like other small peptides, is not generated by messanger RNA-directed ribosomal protein synthesis, but it is synthesized from free amino acids within each cell (2).

Keywords

Free Amino Acid Coronary Sinus Coronary Flow Diastolic Pressure Tissue Content 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. 1.
    Mc Intyre, T.M., Curthoys, N.P. Int. J. Biochem. 12: 545–551, 1980.CrossRefGoogle Scholar
  2. 2.
    Meister, A. In: The Enzymes (Ed. P.B. Boyer), III Vol. 10, Academic Press, New York, 1974, pp. 671–697.Google Scholar
  3. 3.
    Anderson, M.E., Bridges, R.J., Meister, A. Biochem. Biophys. Res. Comm. 96: 848–853, 1980.PubMedCrossRefGoogle Scholar
  4. 4.
    Bartoli, G.M., Haberle, D., Sies, M. In: Functions of Glutathione in Liver and Kidney (Eds. M. Sies, A. Wendel), Springer, Heidelberg, 1978, pp. 27–31.CrossRefGoogle Scholar
  5. 5.
    Schulman, J.D., Goodman, J.J., Mace, J.W., Patrick, A.D., Tietze, F., Butler, E.J. Biochem. Biophys. Res. Commun. 65: 68–74, 1975.PubMedCrossRefGoogle Scholar
  6. 6.
    Curello, S., Ceconi, C., Bigoli, C., Ferrari, R., Albertini, A., Guarnieri, C. Experientia 41: 42–43, 1985.PubMedCrossRefGoogle Scholar
  7. 7.
    Ferrari, R., Ceconi, C., Curello, S., Guarnieri, C., Albertini, A., Visioli, O. J. Mol. Cell. Cardiol. 17: 937–945, 1985.PubMedCrossRefGoogle Scholar
  8. 8.
    Ferrari, R., Ceconi, C., Curello, S., Cargnoni, A., Agnoletti, G., Boffa, G.M., Visioli, O. Eur. Heart J. 7: 3–12, 1986.PubMedGoogle Scholar
  9. 9.
    Ferrari, R., Ceconi, C., Curello, S., Cargnoni, A., Albertini, A., Visioli, O. In: Biochemical Aspects of Physical Exercise (Eds. G. Benzi, L. Packer, N. Siliprandi), Elsevier, Amsterdam, 1986, pp. 145–156.Google Scholar
  10. 10.
    Ishikawa, H., Sies, H., J. Biol. Chem. 42: 3838–3842, 1984.Google Scholar
  11. 11.
    Curello, S., Ceconi, C., Cargnoni, A., Medici, D., Ferrari, R. J. Appl. Cardiol. 1: 31–327, 1986.Google Scholar
  12. 12.
    Isaacs, J., Binkley, F. Biochem. Biophys. Acta 497: 192–204, 1977.PubMedCrossRefGoogle Scholar
  13. 13.
    Mannervik, B., Axelsson, K. Biochem. J. 190: 125–130, 1980.PubMedCentralPubMedGoogle Scholar
  14. 14.
    Meister, A., Tate, S.S. Ann. Rev. Biochem. 45: 559–604, 1976.PubMedCrossRefGoogle Scholar
  15. 15.
    Doroshow, J.H., Locker, G.Y., Myers, CE. J. Clin. Invest. 65: 128–135, 1980.PubMedCentralPubMedCrossRefGoogle Scholar
  16. 16.
    Ferrari, R., Ceconi, C., Curello, S., Cargnoni, A., Albertini, A., Visioli, O. In: Myocardial Ischaemia (Eds. N.S. Dhalla, I.R. Innes, R.E. Beamish), Nijhoff Publishing, Boston, 1987, pp. 67–85.CrossRefGoogle Scholar
  17. 17.
    Meerson, F.Z., Kagan, V.E., Kozov, Yu.P., Belkina, L.M., Arkhipenko, Yu.V. Bas. Res. Cardiol. 77: 465–485, 1982.CrossRefGoogle Scholar
  18. 18.
    Hess, M.L., Okabe, E., Kontos, H.A. J. Mol. Cell. Cardiol. 13: 767–772, 1981.PubMedCrossRefGoogle Scholar
  19. 19.
    Harris, E.J., Booth, R., Cooper, M.B. Febs. Lett 146: 267–272, 1982.PubMedCrossRefGoogle Scholar
  20. 20.
    Bulkley, G.B. Surgery 94: 407–414, 1983.PubMedGoogle Scholar
  21. 21.
    Fridovich, I. Science 201: 875–880, 1978.PubMedCrossRefGoogle Scholar
  22. 22.
    Freeman, B.A., Crapo, M.D. Lab. Invest. 47: 412–426, 1982.PubMedGoogle Scholar
  23. 23.
    Tappel, A.L. Fed. Proc. 32: 1870–1874, 1973.PubMedGoogle Scholar
  24. 24.
    Chanche, B., Sies, H., Boveris, A. Physiol. Rev. 59: 527–605, 1979.Google Scholar
  25. 25.
    Guarnieri, C., Flamigni, F., Caldarera, C.M. J. Mol. Cell. Cardiol. 12: 797–808, 1980.PubMedCrossRefGoogle Scholar
  26. 26.
    Gaudel, Y., Duvelleroy, M.A. J. Mol. Cell. Cardiol. 16: 459–470, 1984.CrossRefGoogle Scholar
  27. 27.
    Roy, R.S., Mc Cord, J.M. In: Radicals and their Scavangers Systems (Eds. R. Greewald, G. Cohen), Elsevier Science, New York, 1983, pp. 145–153.Google Scholar
  28. 28.
    Jolly, S.R., Kane, W.J., Bailie, M.B., Abrams, G.D., Lucchesi, B.R. Circ. Res. 54: 277–285, 1984.PubMedCrossRefGoogle Scholar
  29. 29.
    Raczniak, T.J., Chesney, C., Allen, J.R., J. Mol. Cell. Cardiol. 9: 215–223, 1977.CrossRefGoogle Scholar
  30. 30.
    Sordal, L.A., Mc Collum, W.B., Wood, W.G., Schwartz, A. Am. J. Phys. 224: 497–502, 1973.Google Scholar
  31. 31.
    Mc Cord, J.M. N. Engl. J. Med. 17: 159–163, 1985.Google Scholar
  32. 32.
    Tietze, F. Analyt. Biochem. 27: 502–522, 1969.PubMedCrossRefGoogle Scholar
  33. 33.
    Curello, S., Ceconi, C., Cargnoni, A., Cornacchiari, A., Ferrari, R., Albertini, A. Clin. Chem. 33: 1987 (in press).Google Scholar
  34. 34.
    Meister, A. In: Methods in Enzymology (Ed. A. Meister), Academic Press, New York, Vol. 113, 1985, pp. 571–585.Google Scholar

Copyright information

© Kluwer Academic Publishers 1988

Authors and Affiliations

  • R. Ferrari
    • 1
  • S. Curello
    • 1
  • C. Ceconi
    • 1
  • A. Cargnoni
    • 1
  • E. Condorelli
    • 1
  • A. Albertini
    • 1
  1. 1.University of BresciaItalia

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