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The Biology of Oxygen Radicals: Threats and Defenses

  • Chapter
Oxygen Radicals in the Pathophysiology of Heart Disease

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 86))

Abstract

Ground state dioxygen is predisposed to reduction by a univalent pathway which entails the formation of the reactive intermediates O2 -, H2O2, and HO·. These species are produced during the passage of ionizing radiation through aerated aqueous solutions. Indeed, the superoxide radical (O2 -) and the hydroxyl radical (HO·) were first identified by radiation chemists and have been extensively studied by the technique of pulse radiolysis (1,2).

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Author information

Authors and Affiliations

  1. Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, 27710, USA

    Irwin Fridovich

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  1. Irwin Fridovich
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Editor information

Editors and Affiliations

  1. Division of Cardiovascular Sciences, St. Boniface General Hospital Research Center, Winnipeg, Manitoba, R3E 0W3, Canada

    Pawan K. Singal

  2. Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, R3E 0W3, Canada

    Pawan K. Singal

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© 1988 Kluwer Academic Publishers

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Fridovich, I. (1988). The Biology of Oxygen Radicals: Threats and Defenses. In: Singal, P.K. (eds) Oxygen Radicals in the Pathophysiology of Heart Disease. Developments in Cardiovascular Medicine, vol 86. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1743-2_1

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  • DOI: https://doi.org/10.1007/978-1-4613-1743-2_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8979-1

  • Online ISBN: 978-1-4613-1743-2

  • eBook Packages: Springer Book Archive

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