Abstract
The mode of spread of Hodgkin’s disease within the body has been a subject of controversy [1–4]. One feature of lymphomas is that they originate from cells that have the potential to circulate. This should influence our thoughts about the ways the disease progresses and disseminates. The concept of lymphatic spread in the initial phase of Hodgkin’s disease as favored by Kaplan has been opposed by the ideas of early hematogenous spread [2–4]. The different views have consequences for the approach to therapy. The results of local radiotherapy in localized Hodgkin’s disease supported the opinion of Kaplan [5, 6]. However, further improvement in radiotherapy results has been achieved by the introduction of extended field irradiation [7]. This therapy can not be considered as being restricted to lymph nodes alone, but it also harbors an element of more systemic therapy since lymphocytes in adjacent noninvolved lymph nodes and circulating blood cells are also exposed. The finding that impaired cellular immunity occurred in stages of the disease that were considered to be restricted to one or two lymph node groups can be taken as an argument against a purely local disorder [8, 9].
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References
Rosenberg SA, Kaplan HS: Evidence for an orderly progression in the spread of Hodgkin’s disease. Cancer Res 26:1225–1231, 1966.
Smithers DW: Modes of spread, In: Smithers DW (ed) Hodgkin’s disease. Edinburgh: Churchill-Livingstone, 1973, pp 107–117.
Halie MR, Eibergen R, Nieweg HO: Observations on abnormal cells in the peripheral blood and spleen in Hodgkin’s disease. Br Med J 2:609–611, 1972.
Halie MR, Seldenrath JJ, Stam HC, Nieweg HO: Curative radiotherapy in Hodgkin’s disease: significance of haematogenous dissemination established by examination of peripheral blood and spleen. Br Med J 2:611–613, 1972.
Peters MV: A study of survivals in Hodgkin’s disease treated radiologically. Am J Roentgenol 63:299–311, 1950.
Kaplan HS: The radical radiotherapy of regionally localized Hodgkin’s disease. Radiology 78:553–561, 1962.
Kaplan HS: Long-term results of palliative and radical radiotherapy of Hodgkin’s disease. Cancer Res 26:1250–1252, 1966.
Aisenberg AC: Studies on delayed hypersensitivity in Hodgkin’s disease. J Clin Invest 41:1964–1970, 1962.
De Gast GC, Halie MR, Nieweg HO: Immunological responsiveness against two primary antigens in untreated patients with Hodgkin’s disease. Eur J Cancer 11:217–224, 1975.
Varadi S: Reed-Sternberg cells in peripheral blood and bone marrow in Hodgkin’s disease. Br Med J 1:1239–1243, 1960.
Bouroncle BA: Sternberg-Reed cells in the peripheral blood of patients with Hodgkin’s disease. Blood 27:544–556, 1966.
Halie MR, Huiges W, Nieweg HO: Abnormal cells in the peripheral blood of patients with Hodgkin’s disease. Br J Haematol 28:317–322, 1974.
Halie MR, Splett-Romascano M, Molenaar I, Nieweg HO: Abnormal cells in the peripheral blood of patients with Hodgkin’s disease. II. Ultrastructural studies. Br J Haematol 28, 323–328, 1974.
Engeset A, Hoeg K, Host H, Liverud K, Nesheim A: Thoracic duct lymph cytology in Hodgkin’s disease. Int J Cancer 4:735–742, 1969.
Zucker-Franklin D, Grusky G, Baez L: Reed-Sternberg cells cultured from morphologically unidentifiable precursors in the blood of patients with Hodgkin’s disease. Haematol Oncol 1:127–138, 1983.
Roberts SS, Hengesh JW, McGrath RG, Valaitis J, McGrew EA, Cole WH: Prognostic significance of cancer cells in the circulating blood: a ten year evaluation. Am J Surg 113:757–762, 1967.
Schiffer CA, Levi JA, Wiernik PH: The significance of abnormal circulating cells in patients with Hodgkin’s disease. Br J Haematol 31:177–183, 1975.
Halie MR, Hamers J, Van Larebeke N, Van Hove WZ, Nieweg HO: Abnormal circulating cells and splenic involvement in Hodgkin’s disease. Neth J Med 19:209–214, 1976.
Kaplan HS: Hodgkin’s disease, 2nd edn. Cambridge MA: Harvard University, 1980.
Holm G, Mellstedt H, Björkholm M, Johansson B, et al.: Lymphocyte abnormalities in untreated patients with Hodgkin’s disease. Cancer 37:751–762, 1976.
Romagnani S, Ferrini PL, Ricci M: The immune derangement in Hodgkin’s disease. Semin Hematol 22:41–55, 1985.
Posner MR: Lymphoid subpopulations of peripheral blood and spleen in untreated Hodgkin’s disease. Cancer 48:1170–1176, 1981.
Huber C, Michlmayr G, Falkensamer M, et al.: Increased proliferation of T lymphocytes in the blood of patients with Hodgkin’s disease. Clin Exp Immunol 21:47–53, 1975.
Björkholm M, Holm GL, Ljungdahl A, Strömberg M, Askergren J: Spontaneously DNA synthesizing blood and spleen lymphocytes in Hodgkin’s disease. Scand J Haematol 26:97–105, 1981.
Kuper SWA, Bignall JR: Tritiated-thymidine uptake by tumour cells in blood. Lancet 1:1412–1414, 1964.
Crowther D, Hamilton Fairley G, Sewell RL: Significance of the changes in the circulating lymphoid cells in Hodgkin’s disease. Br Med J 2:473–477, 1969.
De Pauw BE, De Mulder PHM, Smeulders JBJM, Wagener DJTh, Haanen C: Spontaneous transformation of low density lymphocytes as parameter of activity in Hodgkin’s disease. Scand J Haematol 25:58–62, 1980.
Shiftan TA, Calvies AP, Mendelsohn J: Spontaneous lymphocyte proliferation and depressed cellular immunity in Hodgkin’s disease. Clin Exp Immunol 32:144–152, 1978.
De Pauw BE, De Mulder PHM, Geestman EJM, Wessels JMC, Wagener DJTh, Haanen C: Selection of lymphocytes spontaneously transformed in vivo by means of density centrifugation. Neth J Med 23:51–53, 1980.
De Pauw BE, Wessels JMC, Geestman EJM, Smeulders JBJM, Wagener DJTh, Haanen C: Non-selective lymphocyte isolation from human blood by nylon wool filtration and density centrifugation. J Immunol Methods 25:291–295, 1979.
Huber C, Lutz D, Niederweiser D, et al: Prognostic significance of lymphocyte density distribution profiles in adult non-Hodgkin’s lymphoma. Blood 60:1397–1402, 1982.
De Witte Th: Physical elimination of lymphocytes from human bone marrow. Thesis, University of Nijmegen, Nijmegen, The Netherlands, 1985.
Jansen JThP: Characteristics of lymphocytes in Hodgkin’s disease. Thesis, University of Nijmegen, Nijmegen, The Netherlands, 1985.
De Pauw BE, Wagener T, Wessels H, Haanen C: Spontaneous DNA synthesis by sub-populations of lymphocytes in Hodgkin’s disease. Eur J Cancer 16:1329–1332, 1980.
De Pauw BE, Wagener DJTh, Smeulders JBJM, Geestman EJM, Wessels JMC, Haanen C: Lymphocyte density distribution profile and spontaneous tranformation related to the stage of Hodgkin’s disease. Br J Haematol 44:359–364, 1980.
De Mulder PHM, De Pauw BE, Wagener DJTh, Haanen C: Spontaneous lymphocyte tranformation in relation to the number of circulating lymphocytes in Hodgkin’s disease. Blut 42:249–252, 1981.
De Pauw BE, Wagener DJT, Smeulders J, Geestman E, Wessels H, Haanen C: High spontaneous thymidine incorporation into a non-T lymphocyte population in Hodgkin’s disease unmasked after cell fractionation. Cancer 45:516–519, 1980.
Bunting CD: The blood picture in Hodgkin’s disease: second paper. Bull Johns Hopkins Hosp 25:173–177, 1914.
Klima R: Grundlagen fur eine Neuordnung der Hämatologie Zellularer Reaktionen im lymphatischen Apparat. Wien Z Inn Medizin 33:125–135, 1952.
Hersch EM, Buttler WT, Rossen RD, Morgan RO, Suki W: In vitro studies of the human response to organ allografts: appearance and detection of circulating activation lymphocytes. J Immunol 107:571–578, 1971.
De Pauw BE, Janssen JThP, Vaissier P, Haanen C: Occurrence of herpes zoster varicella infections after completion of treatment for Hodgkin’s disease. Neth J Med 26:301–303, 1983.
Kantor FS: Infection, anergy and cell-mediated immunity. N Engl J Med 292:629–634, 1975.
Souhami KL, Babbage J, Sigfusson A: Defective in vitro antibody production to varicella zoster and other virus antigens in patients with Hodgkin’s disease. Clin Exp Immunol 53:292–307, 1983.
Ten Napel ChrHH, The TH, Bijker J, De Gast GC, Halie MR, Langenhuysen MMAC: Discordance of Epstein-Barr virus (EBV) specific humoral and cellular immunity in patients with malignant lymphomas: elevated antibody titres and lowered in vitro lymphocyte reactivity. Clin Exp Immunol 34:338–346, 1978.
Peckham MJ, Cooper EH: Cell production in Hodgkin’s disease. Natl Cancer Inst Monogr 36:179–189, 1973.
Frydecka I: Natural killer cell activity during the course of disease in patients with Hodgkin’s disease. Cancer 56:7999–2803, 1985.
Smit JW, Blom NR, Van Luyn MJA, Halie MR: Parallel tubular structures in T, B and null lymphocyte subpopulations. Acta Haematol 70:108–118, 1982.
Smit JW, Van der Giessen M, Halie MR: FCγreceptors on lymphocytes from normal donor and patients with lymphoproliferative diseases: influence of incubation conditions. Acta Haematol 70:108–118, 1983.
Smit JW, Blom NR, Van Luyn MJA, Van Imhoff GW, Halie MR: Effect of sera from patients with Hodgkin’s disease on normal donor lymphocytes containing parallel tubular structures. Blut 48:109–115, 1984.
Hoogeveen YL, Smit JW, Blom NR, Van Luyn MJA, Halie MR: α-interferon induction of lymphocytes containing parallel tubular structures. Blut 56:55–63, 1988.
Stuart A, Williams ARW, Habeshaw YA: Rosetting and other reactions of the Reed-Sternberg cell. J Pathol 122:81–90, 1977.
Kesselman M, Sasyniuk A, Hryniuk W: Buffy-coat leucocytes in Hodgkin’s disease. Lancet 2:977, 1972.
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© 1989 Kluwer Academic Publishers, Boston
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Halie, M.R., de Pauw, B.E., Smit, J.W. (1989). Circulating cells in Hodgkin’s disease. In: Kamps, W.A., Humphrey, G.B., Poppema, S. (eds) Hodgkin’s Disease in Children. Cancer Treatment and Research, vol 41. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1739-5_7
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DOI: https://doi.org/10.1007/978-1-4613-1739-5_7
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