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The Sternberg-Reed cell

A Cell-fusion Product?

  • Chapter
Hodgkin’s Disease in Children

Part of the book series: Cancer Treatment and Research ((CTAR,volume 41))

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Abstract

Hodgkin’s disease (HD), with its peculiar Sternberg-Reed (SR) cell, is in particular very contradictory. The controversies are most prominent regarding the SR cell origin. Among the cells composing the structure of a normal lymph node, there is almost no cell that has not been suspected as being the normal counterpart of the SR cell. In this chapter, the most relevant opinions are summarized in an attempt to resolve some conflicting evidence regarding the SR cell origin, and thus also explain some other pecularities of the disease.

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References

  1. Poppema S, Kaiserling E, Lennert K: Nodular paragranuloma and progressively transformed germinal centers. Virchows Arch [Cell Pathol] 31:211–225, 1979.

    Article  CAS  Google Scholar 

  2. Poppema S: The diversity of the immunohistological staining pattern of Sternberg-Reed cells. J Histochem Cytochem 28:788–791, 1980.

    Article  PubMed  CAS  Google Scholar 

  3. Kadin ME, Billing RJ: B lymphocyte antigens in the differential diagnosis of human neoplasia. Blood 51:813–823, 1978.

    PubMed  CAS  Google Scholar 

  4. Pinkus GS, Said JW: Hodgkin’s disease, lymphocyte predominance type, nodular: a distinct entity? Am J Pathol 118:1–6, 1985.

    PubMed  CAS  Google Scholar 

  5. Poppema S, De Jong B, Atmosoerodjo J, Idenburg V, Visser L, De Ley L: Morphologic, immunologic, enzyme histochemical and chromosomal analysis of a cell line derived from Hodgkin’s disease. Cancer 55:683–690, 1985.

    Article  PubMed  CAS  Google Scholar 

  6. Stuart AE, Volsen SG, Zola H: The reactivity of Reed-Sternberg cells with monoclonal antisera at thin section and ultrastructural levels. J Pathol 141:71–82, 1983.

    Article  PubMed  CAS  Google Scholar 

  7. Lynch DC, Berliner M, O’Flynn K, et al.: Hodgkin-cell leukaemia of B-cell origin. Lancet 1:78–80, 1985.

    Article  Google Scholar 

  8. Dorreen M, Habeshaw JA, Stansfeld AG, Wrigley PFM, Lister TA: Characteristics of Sternberg-Reed, and related cells in Hodgkin’s disease: an immunohistological study. Br J Cancer 49:465–476, 1984.

    Article  PubMed  CAS  Google Scholar 

  9. Umihara J, Tanaka M, Tanaka H, Saito K, Ishikawa E: Hodgkin’s disease: a histochemical study with special emphasis on the character of Hodgkin’s cell and Reed-Sternberg cell. Acta Pathol Jpn 33:751–759, 1983.

    PubMed  CAS  Google Scholar 

  10. Bernuau D, Feldmann G, Vorhauer W: Hodgkin’s disease: ultrastructural localisation of intra-cytoplasmic immunoglobulins within malignant cells. Br J Haematol 40:51–57, 1978.

    Article  PubMed  CAS  Google Scholar 

  11. Reynes M, Paczynski V, Galtier M, Diebold J: Ultrastructural and immunocytochemical localisation of immunoglobulin synthesis in tumor cells in Hodgkin’s disease. Int J Cancer 23:474–481, 1979.

    Article  PubMed  CAS  Google Scholar 

  12. Poppema S, Elema JD, Halie MR: The significance of intracytoplasmic proteins in Reed-Sternberg cells. Cancer 42:1793–1803, 1978.

    Article  PubMed  CAS  Google Scholar 

  13. Landaas TO, Godal T, Halvorsen TB: Characterization of immunoglobulins in Hodgkin cells. Int J Cancer 20:717–722, 1977.

    Article  PubMed  CAS  Google Scholar 

  14. Mori N, Oka K, Sakuma H, Tsunoda R, Kojima M: Immunoelectron microscopic study of Hodgkin’s disease. Cancer 56:2605–2611, 1985.

    Article  PubMed  CAS  Google Scholar 

  15. Kadin ME, Stites DP, Levy R, Warnke R: Exogenous immunoglobulin and the macrophage origin of Reed-Sternberg cells in Hodgkin’s disease. N Engl J Med 299:1208–1214, 1978.

    Article  PubMed  CAS  Google Scholar 

  16. Payne SV, Wright DH, Jones KJM, Judd MA: Macrophage origin of Reed-Sternberg cells: an immunohistochemical study. J Clin Pathol 35:159–166, 1982.

    Article  PubMed  CAS  Google Scholar 

  17. Kaplan HS: Hodgkin’s disease: biology, treatment, prognosis. Blood 57:813–822, 1981.

    PubMed  CAS  Google Scholar 

  18. Strauchen JA: Lectin receptors as markers of lymphoid cells. II. Reed-Sternberg cells share lectin-binding properties of monocyte macrophages. Am J Pathol 116:370–376, 1984.

    PubMed  CAS  Google Scholar 

  19. Resnick GD, Nachman RL: Reed-Sternberg cells in Hodgkin’s disease contain fibronectin. Blood 57:339–342, 1981.

    PubMed  CAS  Google Scholar 

  20. Katz DR: The macrophage in Hodgkin’s disease. J Pathol 133:145–159, 1981.

    Article  PubMed  CAS  Google Scholar 

  21. Peiper SC, Kahn LB, Ross WD, Reddick RL: Ultrastructural organisation of the Reed-Sternberg cell: its resemblance to cells of the monocyte-macrophage system. Blood Cells 6:515–523, 1980.

    PubMed  CAS  Google Scholar 

  22. Kadin ME: Possible origin of the Reed-Sternberg cell from an interdigitating reticulum cell. Cancer Treat Rep 60:601–608, 1982.

    Google Scholar 

  23. Hsu SM, Yang K, Jaffe ES: Phenotypic expression of Hodgkin’s and Reed-Sternberg cells in Hodgkin’s disease. Am J Pathol 118:209–217, 1985.

    PubMed  CAS  Google Scholar 

  24. Beckstead JM, Warnke R, Bainton DF: Histochemistry of Hodgkin’s disease. Cancer Treat Rep 66:609–613, 1982.

    PubMed  CAS  Google Scholar 

  25. Curran RC, Jones EL: Hodgkin’s disease: an immunohistochemical and histological study. J Pathol 125:39–51, 1978.

    Article  PubMed  CAS  Google Scholar 

  26. Fisher RJ, Bostick-Bruton F, Sauder N, Scala G, Diehl V: Neoplastic cells obtained from Hodgkin’s disease are potent stimulators of human primary mixed lymphocyte cultures. J Immunol 130:2666–2670, 1983.

    PubMed  CAS  Google Scholar 

  27. Fisher RJ, Bates SA, Bostick-Bruton F, Tuteja N, Diehl V: Neoplastic cells obtained from Hodgkin’s disease function as accessory cells for mitogen induced human T cell proliferative responses. J Immunol 132:2672–2677, 1984.

    PubMed  CAS  Google Scholar 

  28. Fisher RJ, Cossman J, Diehl V, Volkman DY: Antigen presentation by Hodgkin’s disease cells. J Immunol 135:3568–3571, 1985.

    PubMed  CAS  Google Scholar 

  29. Order SE, Hellman S: Pathogenesis of Hodgkin’s disease. Lancet 1:571–573, 1972.

    Article  PubMed  CAS  Google Scholar 

  30. Biniaminov M, Ramot B: Possible T-lymphocyte origin of Reed-Sternberg cells. Lancet 1:368, 1974.

    Article  PubMed  CAS  Google Scholar 

  31. Schnitzer B: Origin of malignant lymphomas. Lancet 2:960, 1974.

    Article  PubMed  CAS  Google Scholar 

  32. Kadin ME: Common activated helper-T-cell origin for lymphomatoid papulosis, mycosis fungoides, and some types of Hodgkin’s disease. Lancet 2:864–865, 1985.

    Article  PubMed  CAS  Google Scholar 

  33. Lewis MR: The behavior of Dorothy Reed cells in tissue cultures. Am J Med Sci 201:467, 1941.

    Article  Google Scholar 

  34. Stein H, Uchanska-Ziegler B, Gerdes J, Ziegler A, Wernet P: Hodgkin and Sternberg-Reed cells contain antigens specific for late cells of granulopoiesis. Int J Cancer 29:283–290, 1982.

    Article  PubMed  CAS  Google Scholar 

  35. Stein H, Gerdes J, Schwab U, et al.: Identification of Hodgkin and Sternberg-Reed cells as a unique cell type derived from a newly-detected small-cell population. Int J Cancer 30:445–459, 1982.

    Article  PubMed  CAS  Google Scholar 

  36. Stein H, Gerdes J, Schwab U, et al.: Evidence for the detection of the normal counterpart of Hodgkin and Sternberg-Reed cells. Hematol Oncol 1:21–29, 1983.

    Article  PubMed  CAS  Google Scholar 

  37. Olsson L: On the natural biology of the malignant cells in Hodgkin’s disease. Int J Radiat Oncol Biol Phys 11:37–48, 1985.

    Article  PubMed  CAS  Google Scholar 

  38. Lane D, Koprowski H: Molecular recognition and the future of monoclonal antibodies. Nature 296:200–201, 1982.

    Article  PubMed  CAS  Google Scholar 

  39. Weiss LM, Crabtree GS, Rouse RV, Warnke RA: Morphologic and immunologic characterization of 50 peripheral T-cell lymphomas. Am J Pathol 118:316–324, 1985.

    PubMed  CAS  Google Scholar 

  40. Greaves MF, Chan LC, Furley AJW, Watt SM, Molgaard HV: Lineage promiscuity in hemopoietic differentiation and leukemia. Blood 67:1–11, 1986.

    PubMed  CAS  Google Scholar 

  41. Andreesen R, Osterholz J, Löhr GW, Gross KJ: A Hodgkin cell-specific antigen is expressed on a subset of auto- and alloactivated T (helper) lymphoblasts. Blood 63:1299–1302, 1984.

    PubMed  CAS  Google Scholar 

  42. Stein H, Mason DY, Gerdes J, et al.: The expression of the Hodgkin’s disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells. Blood 66:848–858, 1985.

    PubMed  CAS  Google Scholar 

  43. Warner TFCS: Origin of the Reed-Sternberg cell. Lancet 2:511, 1973.

    Article  PubMed  CAS  Google Scholar 

  44. Sinkovics JG, Schullenberger CC: Hodgkin’s disease. Lancet 2:506–507, 1975.

    Article  PubMed  CAS  Google Scholar 

  45. Peckham MJ, Cooper EH: Cell proliferation in Hodgkin’s disease. Natl Cancer Inst Monogr 36:179–189, 1973.

    PubMed  CAS  Google Scholar 

  46. Bucsky P: Origin of Hodgkin’s and Reed-Sternberg cells. N Engl J Med 303:284, 1980.

    PubMed  CAS  Google Scholar 

  47. Hehlmann R, Kufe D, Spiegelman S: Viral-related RNS in Hodgkin’s disease and other human lymphomas. Proc Natl Acad Sci USA 69:1727–1731, 1972.

    Article  PubMed  CAS  Google Scholar 

  48. Peckham MJ, Cooper EH: Proliferation characteristics of the various classes of cells in Hodgkin’s disease. Cancer 24:135–146, 1969.

    Article  PubMed  CAS  Google Scholar 

  49. Kadin ME, Asbury AK: Long term cultures of Hodgkin’s tissue: a morphologic and radioautographic study. Lab Invest 28:181–184, 1973.

    PubMed  CAS  Google Scholar 

  50. Taylor CR: Upon the nature of Hodgkin’s disease and the Reed-Sternberg cell. Recent Results Cancer Res 64:214–231, 1978.

    PubMed  CAS  Google Scholar 

  51. Taylor CR, Russel R, Chandor S: An immunohistological study of multiple myeloma and related conditions, using an immunoperoxidase method. Am J Clin Pathol 70:612–622, 1978.

    PubMed  CAS  Google Scholar 

  52. Kovacs G: Premature chromosome condensation: evidence for in vivo cell fusion in human malignant tumours. Int J Cancer 36:637–641, 1985.

    Article  PubMed  CAS  Google Scholar 

  53. Green AR, Wike JA: Anti-oncogenes: a subset of regulatory genes involved in carcinogenesis? Lancet 2:475–477, 1985.

    Article  PubMed  CAS  Google Scholar 

  54. Sklar MD, Kichingman GR: Isolation of activated RAS transforming genes from two patients with Hodgkin’s disease. Int J Radiat Oncol Biol Phys 11:49–55, 1985.

    Article  PubMed  CAS  Google Scholar 

  55. Bayliss GJ, Wolf H: An Epstein-Barr virus early protein induces cell fusion. Proc Natl Acad Sci USA 78:7162–7165, 1981.

    Article  PubMed  CAS  Google Scholar 

  56. Miller G, Lipman M: Release of infectious Epstein-Barr virus by transformed marmoset leukocytes. Proc Natl Acad Sci USA 70–190–194, 1973.

    Google Scholar 

  57. Evans AS, Comstock GW: Presence of elevated antibody titres to Epstein-Barr virus before Hodgkin’s disease. Lancet 1:1183–1186, 1981.

    Article  PubMed  CAS  Google Scholar 

  58. Evans AS, Gutensohn MM: A population-based case-control study of EBV and other viral antibodies among persons with Hodgkin’s disease and their siblings. Int J Cancer 34:149–157, 1984.

    Article  PubMed  CAS  Google Scholar 

  59. Lange B, Arbeter A, Hewetson J, Henle W: Longitudinal study of Epstein-Barr virus antibody titers and excretion in pediatric patients with Hodgkin’s disease. Int J Cancer 22:521–527, 1978.

    Article  PubMed  CAS  Google Scholar 

  60. Munoz N, Davidson RJL, Witthoff B, Ericsson JE, De The G: Infectious mononucleosis and Hodgkin’s disease. Int J Cancer 22:10–13, 1978.

    Article  PubMed  CAS  Google Scholar 

  61. Klein G, Klein E: The changing faces of EBV research. Prog Med Virol 30:87–106, 1984.

    PubMed  CAS  Google Scholar 

  62. Frache R, Barel M, Ehlin-Henriksson B, Klein G: gp 140, the C3d receptor of human B lymphocytes, is also the Epstein-Barr virus receptor. Proc Natl Acad Sci USA 82:1490–1493, 1985.

    Article  Google Scholar 

  63. Frickhofen N, Bross KJ, Heit W, Heimpel H: Modified immunocytochemical slide technique for demonstrating surface antigens on viable cells. J Clin Pathol 38:671–676, 1985.

    Article  PubMed  CAS  Google Scholar 

  64. Drexler HG, Gaedicke G: Isoenzyme studies in human leukemia. II. Carboxylic esterase (E.C.3.1.1.1.1.). Leuk Res 7:599–609, 1983.

    Article  PubMed  CAS  Google Scholar 

  65. Löftier H: Cytochemischer Nachweis von unspezifischer Esterase in Ausstrichen. Klin Wochenschr 23:1220–1227, 1961.

    Google Scholar 

  66. Reedman BM, Klein G: Cellular localisation of an Epstein-Barr virus (EBV)-associated complement-fixing antigen in producer and nonproducer lymphoblastoid cell lines. Int J Cancer 11:499–520, 1973.

    Article  PubMed  CAS  Google Scholar 

  67. Bucsky PP, et al. 1987 (in press).

    Google Scholar 

  68. Rickinson A: Epstein-Barr virus in epithelium. Nature 310:99–100, 1984.

    Article  PubMed  CAS  Google Scholar 

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© 1989 Kluwer Academic Publishers, Boston

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Bucsky, P.P. (1989). The Sternberg-Reed cell. In: Kamps, W.A., Humphrey, G.B., Poppema, S. (eds) Hodgkin’s Disease in Children. Cancer Treatment and Research, vol 41. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1739-5_4

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  • DOI: https://doi.org/10.1007/978-1-4613-1739-5_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8978-4

  • Online ISBN: 978-1-4613-1739-5

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