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Evidence for a B-cell origin of the proliferating cells

  • Sibrand Poppema
  • Marja G. L. Brinker
  • Lydia Visser
Part of the Cancer Treatment and Research book series (CTAR, volume 41)

Abstract

Hodgkin’s disease differs from the non-Hodgkin’s lymphomas by the presence of reactive lymphocytes, histiocytes, plasma cells, fibroblasts and eosinophils in addition to the abnormal so-called Reed-Sternberg cells and their variants (Figure 1). Usually, Reed-Sternberg cells constitute only a minor population, whereas there is a majority of reactive small lymphocytes. During the disease, there is a general tendency to an increase in the number of Reed-Sternberg cells and a decrease in the lymphocyte admixture. The non-Hodgkin’s lymphomas have been demonstrated to be monoclonal proliferations of B- or T-lymphocytes, but in Hodgkin’s disease neither the cell of origin nor the monoclonal origin of the Reed-Sternberg cells has been established with certainty.

Keywords

Gene Rearrangement Clonal Rearrangement Immunoglobulin Gene Rearrangement Interdigitating Reticulum Cell Sternberg Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Garvin AJ, Spicer SS, Parmley L, Munster AM: Immunohistochemical demonstration of IgG in Reed-Sternberg cells and other cells in Hodgkin’s disease. J Exp Med 139:1077–1083, 1974.PubMedCrossRefGoogle Scholar
  2. 2.
    Leech J: Immunoglobulin positive Reed-Sternberg cells in Hodgkin’s disease. Lancet 2:265–266, 1973.PubMedCrossRefGoogle Scholar
  3. 3.
    Taylor CR: The nature of Reed-Sternberg cells and other malignant reticulum cells. Lancet 2:802–807, 1974.PubMedCrossRefGoogle Scholar
  4. 4.
    Poppema S, Elema JD, Halie MR: The significance of intracytoplasmic proteins in Reed-Sternberg cells. Cancer 42:1793–1803, 1978.PubMedCrossRefGoogle Scholar
  5. 5.
    Papadimitrou CS, Stein H, Lennert K: The complexity of the immunohistochemical staining pattern of Hodgkin and Sternberg-Reed cells: demonstration of immunoglobulin, albumin, alpha-1-antitrypsin and lysozyme. Int J Cancer 21:531–541, 1978.CrossRefGoogle Scholar
  6. 6.
    Kadin ME, Stites DP, Levy R, Warnke R: Exogenous immunoglobulin and the macrophage origin of Reed-Sternberg cells in Hodgkin’s disease. N Engl J Med 299:1208–1214, 1978.PubMedCrossRefGoogle Scholar
  7. 7.
    Kaplan HS, Gartner S: Sternberg-Reed giant cells of Hodgkin’s disease: cultivation in vitro, heterotransplantation, and characterization as neoplastic macrophages. Int J Cancer 19:511–525, 1977.PubMedCrossRefGoogle Scholar
  8. 8.
    Mir R, Kahn LB: Immunohistochemistry of Hodgkin’s disease: a study of 20 cases. Cancer 52:2064–2071, 1983.PubMedCrossRefGoogle Scholar
  9. 9.
    Payne SV, Jones DB, Wright DH: Reed-Sternberg cell-lymphocyte interaction. Lancet 2:768–769, 1977.PubMedCrossRefGoogle Scholar
  10. 10.
    Poppema S, Bhan AK, Reinherz EL, Posner MR, Schlossman SF: In situ immunologic characterization of cellular constituents in lymph nodes and spleen involved by Hodgkin’s disease. Blood 59:226–232, 1982.PubMedGoogle Scholar
  11. 11.
    Forni M, Hofman FM, Parker W, Lukes RT, Taylor CR: B- and T-lymphocytes in Hodgkin’s disease: an immunohistochemical study utilizing heterologous and monoclonal antibodies. Cancer 55:728–737, 1985.PubMedCrossRefGoogle Scholar
  12. 12.
    Stein H, Mason DY, Gerdes J, O’Connor N, Wainscoat J: The expression of the Hodgkin’s disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue. Blood 66:848–858, 1985.PubMedGoogle Scholar
  13. 13.
    Hsu SM, Jaffe ES: Leu Ml and peanut agglutinin stain the neoplastic cells of Hodgkin’s disease. Am J Pathol 82:29–32, 1984.Google Scholar
  14. 14.
    Weiss LM, Strickler JG, Hu E, Warnke R, Sklar J: Immunoglobulin gene rearrangements in Hodgkin’s disease. Hum Pathol 17:1009–1014, 1986.PubMedCrossRefGoogle Scholar
  15. 15.
    Hsu SM, Pescovitc MD, Hsu PL: Monoclonal antibodies against SU-DHL-1 cells stain the neoplastic cells in true histiocytic lymphoma, malignant histiocytosis, and Hodgkin’s disease. Blood 68:213–219, 1986.PubMedGoogle Scholar
  16. 16.
    Poppema S, De Jong B, Atmosoerodjo J, Idenburg V, Visser L, De Leij L: Morphologic, immunologic, enzymehistochemical, and chromosomal analysis of a cell line derived from Hodgkin’s disease. Cancer 55:683–690, 1985.PubMedCrossRefGoogle Scholar
  17. 17.
    Stuart AE, Voisen SG, Zola H: The reactivity of Reed-Sternberg cells with monoclonal antisera at thin level and ultrastructural level. J Pathol 141:71–82, 1983.PubMedCrossRefGoogle Scholar
  18. 18.
    Doreen MS, Habeshaw JA, Stansfeld AG, Wrigley PFM, Lister TA: Characteristics of Sternberg-Reed cells and related cells in Hodgkin’s disease. Br J Cancer 49:465–476, 1984.CrossRefGoogle Scholar
  19. 19.
    Timens W, Visser L, Poppema S: Nodular lymphocyte predominance type of Hodgkin’s disease is a germinal center lymphoma. Lab Invest 54:457–461, 1986.PubMedGoogle Scholar
  20. 20.
    Hsu SM, Zhao X: Expression of interleukin-1 in Reed-Sternberg cells and neoplastic cells from true histiocytic malignancies. Am J Pathol 125:221–225, 1986.PubMedGoogle Scholar
  21. 21.
    Schwab U, Stein H, Gerdes J, et al.:Production of a monoclonal antibody specific for Hodgkin and Sternberg-Reed cells of Hodgkin’s disease and a subset of normal lymphoid cells. Nature 299:65–67, 1982.PubMedCrossRefGoogle Scholar
  22. 22.
    Andreesen R, Osterholz J, Löhr GW, Gross KJ: A Hodgkin cell-specific antigen is expressed on a subset of auto- and alloactivated T (helper) lymphoblasts. Blood 63:1299–1302, 1984.PubMedGoogle Scholar
  23. 23.
    Tokura Y, Takigawa M, Oku T, Yamada M: Lymphomatoid papulosis: histologic and immunohistochemical studies in a patient with a scaly pigmented eruption. Arch Dermatol 122:1400–1405, 1986.PubMedCrossRefGoogle Scholar
  24. 24.
    Kaudewitz P, Stein H, Burg G, Mason DY, Braun-Falco O: Atypical cells in lymphomatoid papulosis express the Hodgkin cell associated antigen Ki-1. J Invest Dermatol 86:350–354, 1986.PubMedCrossRefGoogle Scholar
  25. 25.
    Poppema S, Hollema H: The non Hodgkin lymphomas and Hodgkin’s disease: significance of immunohistological marker analysis. In: Janossy G, Amlot PL (eds) Lymphocytes in health and disease. Lancaster: MTP, 1987 (in press).Google Scholar
  26. 26.
    Stein H, Uchanska-Ziegler B, Gerdes J, Ziegler A, Wernet P: Hodgkin and Sternberg-Reed cells contain antigens specific for late cells of granulopoiesis. Int J Cancer 29:283–290, 1982.PubMedCrossRefGoogle Scholar
  27. 27.
    Sheibani K, Battifora H, Burke JS, Rappaport H: Leu M1 antigen in human neoplasms: an immunohistologic study of 400 cases. Am J Surg Pathol 10:227–236, 1986.PubMedCrossRefGoogle Scholar
  28. 28.
    Poppema S: The diversity of the immunohistologic staining pattern of Sternberg-Reed cells. J Histochem Cytochem 28:788–791, 1980.PubMedCrossRefGoogle Scholar
  29. 29.
    Stein H, Hansmann ML, Lennert K, Brandtzaeg P, Gatter KC, Mason DY: Reed-Sternberg cells and Hodgkin cells in lymphocyte predominant Hodgkin’s disease of nodular subtype contain J chain. Am J Clin Pathol 86:292–297, 1986.PubMedGoogle Scholar
  30. 30.
    Pinkus GS, Said JW: Hodgkin’s disease, lymphocyte predominance type, nodular: a distinct entity? Am J Pathol 118:1–6, 1985.PubMedGoogle Scholar
  31. 31.
    Hsu SM, Ho YS, Li PJ, et al.: L&H variants of Reed-Sternberg cells express syalylated Leu Ml antigen. Am J Pathol 122:193–203, 1986.Google Scholar
  32. 32.
    Galili U, Klein E, Christensson B, Biberfeld P: Lymphocytes of Hodgkin’s biopsies exhibit stable E rosette formation, natural attachment, and glucocorticoid sensitivity similar to immunoactivated T cells. Clin Immunol Immunopathol 16:173–179, 1980.PubMedCrossRefGoogle Scholar
  33. 33.
    Poppema S, Elema JD, Halie MR: The localisation of Hodgkin’s disease in lymph nodes: a study with immunohistological enzymehistochemical and rosetting techniques on frozen sections. Int J Cancer 24:532–537, 1979.PubMedCrossRefGoogle Scholar
  34. 34.
    Borowitz MJ, Croker BP, Metzgar RS: Immunohistochemical analysis of the distribution of lymphocyte subpopulations in Hodgkin’s disease. Cancer Treat Rep 66:667–674, 1982.PubMedGoogle Scholar
  35. 35.
    Morris CS, Stuart AE: Reed-Sternberg/lymphocyte rosette: lymphocyte subpopulations as defined by monoclonal antibodies. J Clin Pathol 37:767–771, 1984.PubMedCrossRefGoogle Scholar
  36. 36.
    Romagnani S, Maggi E, Parronchi P: Clonal analysis of T lymphocytes in spleens from patients with Hodgkin’s disease: frequent occurrence of unusual T4-pos. cells which coex-press cytolytic activity and production of IL2. Int J Cancer 37:343–349, 1986.PubMedCrossRefGoogle Scholar
  37. 37.
    Poppema S, Visser L, De Leij L: Reactivity of presumed antinatural killer cell antibody Leu 7 with intrafollicular T lymphocytes. Clin Exp Immunol 54:834–837, 1983.PubMedGoogle Scholar
  38. 38.
    Velardi A, Mingari MC, Moretta L, Grossi CE: Functional analysis of cloned germinal center CD4+ cells with natural killer cell-related features: divergence from typical T helper cells. J Immunol 137:2808–2813, 1986.PubMedGoogle Scholar
  39. 39.
    Harris NL, Gang DL, Quai C, Poppema S, Nelson-Rees W, O’Brien SJ: Contamination of Hodgkin’s disease cell cultures. Nature 289:228–230, 1981.PubMedCrossRefGoogle Scholar
  40. 40.
    Schaadt M, Diehl V, Stein H, Fonatsch C, Kirchner HH: Two neoplastic cell lines with unique features derived from Hodgkin’s disease. Int J Cancer 26:723–731, 1980.PubMedCrossRefGoogle Scholar
  41. 41.
    Jones DB, Scott CS, Wright DH, et al.: Phenotypic analysis of an established cell line derived from a patient with Hodgkin’s disease. Hematol Oncol 3:133–145, 1985.PubMedCrossRefGoogle Scholar
  42. 42.
    Kamesaki H, Fukuhara S, Tatsumi E, et al.: Cytochemical, immunologic, chromosomal, and molecular genetic analysis of a novel cell line derived from Hodgkin’s disease. Blood 68:285–292, 1986.PubMedGoogle Scholar
  43. 43.
    Bennett MH, MacLennan KA, Easterling MJ: Analysis of histological subtypes in Hodgkin’s disease in relation to prognosis and survival. In: Quaglino D, Hayhoe FGJ (eds) The cytobiology of leukemias and lymphomas. Serono 20. symposia, New York: Raven, 1985.Google Scholar
  44. 44.
    Nilsson K, Ponten J: Classification and biological nature of established human hematopoietic cell lines. Int J Cancer 15:321–330, 1975.PubMedCrossRefGoogle Scholar
  45. 45.
    Nadler LM, Stashenko P, Hardy R, Van Agthoven A, Terhorst, Schlossman SF: Characterization of a human B cell specific antigen (B2) distinct from B1. J Immunol 126:1941–1947, 1981.PubMedGoogle Scholar
  46. 46.
    Poppema S, Van Imhoff G, Torensma R, Smit JW: Lymphadenopathy morphologically consistent with Hodgkin’s disease associated with Epstein-Barr virus infection. Am J Clin Pathol 84:385–390, 1985.PubMedGoogle Scholar
  47. 47.
    Rowley D: Chromosomes in Hodgkin’s disease. Cancer Treat Rep 66:639–644, 1982.PubMedGoogle Scholar
  48. 48.
    Slavutsky I, Abal de Vinuesa M, Estevez ME, Sen L, De Salum SB: Cytogenetic and immunologic phenotype findings in Hodgkin’s disease. Cancer Genet Cytogenet 16:123–130, 1985.PubMedCrossRefGoogle Scholar
  49. 49.
    Hossfeld DK, Schmidt CG: Chromosome findings in effusions from patients with Hodgkin’s disease. Int J Cancer 21:147–156, 1978.PubMedCrossRefGoogle Scholar
  50. 50.
    Newcom SR, O’Rourke L: Potentiation of fibroblast growth by nodular sclerosing Hodgkin’s disease cultures. Blood 60:228–237, 1982.PubMedGoogle Scholar
  51. 51.
    Ford RJ, Mehta S, Davis F, Maizel AL: Growth factors in Hodgkin’s disease. Cancer Treat Rep 66:633–638, 1982.PubMedGoogle Scholar
  52. 52.
    Fisher RI, Bostick-Bruton F, Sauder DN, Scala G, Diehl V: Neoplastic cells obtained from Hodgkin’s disease are potent stimulators of human primary mixed lymphocyte cultures. J Immunol 130:2666–2670, 1983.PubMedGoogle Scholar
  53. 53.
    Diehl V, Kirchner HH, Burrichter H, et al.: Characteristics of Hodgkin’s disease cell lines. Cancer Treat Rep 66:615–632, 1982.PubMedGoogle Scholar
  54. 54.
    Duff G: Many roles for interleukin 1. Nature 313:352–353, 1985.PubMedCrossRefGoogle Scholar
  55. 55.
    Forbes JF, Morris PJ: Analysis of HL-A antigens in patients with Hodgkin’s disease and their families. J Clin Invest 54:1156–1163, 1972.CrossRefGoogle Scholar
  56. 56.
    Perkin E, O’Donnell M: Another observation of increased frequency of HLA-5 and HLA-8 in Hodgkin’s disease. Am J Clin Pathol 64:277–278, 1975.Google Scholar
  57. 57.
    Falk J, Osoba D: HL-A antigens and survival in Hodgkin’s disease. Lancet 2:1118–1120, 1971.PubMedCrossRefGoogle Scholar
  58. 58.
    Torres A, Martinez F, Gomez P, Gomez C, Garcia JM, Nunez-Roldan A: Simultaneous Hodgkin’s disease in three siblings with identical HLA-genotype. Cancer 46:838–843,1980.PubMedCrossRefGoogle Scholar
  59. 59.
    Romagnani S, Almerigogna F, Giudizi MG, et al.: Anti-Ia reactivity in sera of untreated patients with active Hodgkin’s disease. Clin Immunol Immunopathol 34:1–7, 1985.PubMedCrossRefGoogle Scholar
  60. 60.
    Wilbur SM, Bonavida B: Expression of hybrid Ia molecules on the cell surface of reticulum cell sarcomas that are undetectable on host SJL/J lymphocytes. J Exp Med 153:501–513, 1981.PubMedCrossRefGoogle Scholar
  61. 61.
    Lerman SP, Carswell EA, Chapman J, Thorbecke GJ: Properties of reticulum cell sarcomas in SJL/J mice. III. Promotion of tumor growth in irradiated mice by normal lymphoid cells. Cell Immunol 23:53–67, 1976.PubMedCrossRefGoogle Scholar
  62. 62.
    Korsmeyer SJ, Hieter PA, O’Sharrow SO, Goldman CK, Leder P, Waldmann TA: Normal human B cells display ordered light chain gene rearrangements and deletions. J Exp Med 156:975–985, 1982.PubMedCrossRefGoogle Scholar
  63. 63.
    Arnold A, Cossman J, Jaffe ES, Waldmann TA, Korsmeyer SJ: Immunogiobulin-gene rearrangements as unique clonal markers in human lymphoid neoplasms. N Engl J Med 26:1593–1599, 1983.CrossRefGoogle Scholar
  64. 64.
    Cleary ML, Warnke R, Sklar J: Monoclonality of lymphoproliferative lesions in cardiac transplant recipients: clonal analysis based on immunoglobulin gene rearrangements. N Engl J Med 310:477–482, 1984.PubMedCrossRefGoogle Scholar
  65. 65.
    Yanagi Y, Chan A, Chin B, Minden M, Mak TW: Analysis of cDNA clones specific for human T cells and the □ and α-chains of the T cell receptor heterodimer from a human T cell line. Proc Natl Acad Sci USA 82:3430–3434, 1985.PubMedCrossRefGoogle Scholar
  66. 66.
    Weiss LM, Hu E, Wood GS: Clonal rearrangements of T-cell receptor genes in mycosis fungoides and dermatopathic lymphadenopathy. N Engl J Med 313:539–542, 1985.PubMedCrossRefGoogle Scholar
  67. 67.
    Pelicci PG, Knowles DM, Dalla Favera R: Lymphoid tumors displaying rearrangements of both immunoglobulin and T cell receptor genes. J Exp Med 162:1015–1024, 1983.CrossRefGoogle Scholar
  68. 68.
    O’Connor NTJ, Wainscoat JS, Weatherall DJ: Rearrangement of the T-cell receptor α-chain gene in lymphoproliferative disorders. Lancet 1:1295–1298, 1985.PubMedCrossRefGoogle Scholar
  69. 69.
    Ha K, Minden M, Hozumi N, Gelfand EW: Immunoglobulin gene rearrangements in acute myelogenous leukemia. Cancer Res 44:4658–4660, 1984.PubMedGoogle Scholar
  70. 70.
    Cleary ML, Trela MJ, Weiss LM: Most null large cell lymphomas are B cell neoplasms. Lab Invest 53:521–525, 1985.PubMedGoogle Scholar
  71. 71.
    Weiss ML, Trela MJ, Cleary ML: Frequent immunoglobulin and T cell receptor gene rearrangements in ‘histiocytic’ neoplasms. Am J Pathol 121:369–373, 1985.PubMedGoogle Scholar
  72. 72.
    Griesser H, Feller A, Lennert K, Minden M, Mak TW: Rearrangement of the beta chain of the T-cell antigen receptor and immunoglobulin genes in lymphoproliferative disorders. J Clin Invest 78:1179–1184, 1986.PubMedCrossRefGoogle Scholar
  73. 73.
    Weiss LM, Strickler JG, Hu E, Warnke RA, Sklar J: Immunoglobulin gene rearrangements in Hodgkin’s disease. Hum Pathol 17:1009–1014, 1986.PubMedCrossRefGoogle Scholar
  74. 74.
    O’Connor N, Crick JA, Gatter KC, Mason DY, Falini B, Stein HS: Cell lineage in Hodgkin’s disease [letter]. Lancet 1:158, 1987.PubMedCrossRefGoogle Scholar
  75. 75.
    Brinker ML, Poppema S, Buys CHCM, Timens W, Osinga J, Visser L: Clonal immunoglobulin gene rearrangements in tissues involved by Hodgkin’s disease. Blood 1987 70:186–191, 1987.Google Scholar
  76. 76.
    Falk M, Stein H, Tesch H, Diehl V, Jones DB, Bornkamm GW: Immunoglobulin gene rearrangements in in two of four cell lines derived from patients with Hodgkin’s disease. J Immunol (in press).Google Scholar
  77. 77.
    Timens W, Brinker M, Osinga J. et al.: Ig gene rearrangement in Hodgkin’s disease cell line. Exp Hematol 13:421, 1985.Google Scholar

Copyright information

© Kluwer Academic Publishers, Boston 1989

Authors and Affiliations

  • Sibrand Poppema
  • Marja G. L. Brinker
  • Lydia Visser

There are no affiliations available

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