Evidence for a B-cell origin of the proliferating cells

  • Sibrand Poppema
  • Marja G. L. Brinker
  • Lydia Visser
Part of the Cancer Treatment and Research book series (CTAR, volume 41)


Hodgkin’s disease differs from the non-Hodgkin’s lymphomas by the presence of reactive lymphocytes, histiocytes, plasma cells, fibroblasts and eosinophils in addition to the abnormal so-called Reed-Sternberg cells and their variants (Figure 1). Usually, Reed-Sternberg cells constitute only a minor population, whereas there is a majority of reactive small lymphocytes. During the disease, there is a general tendency to an increase in the number of Reed-Sternberg cells and a decrease in the lymphocyte admixture. The non-Hodgkin’s lymphomas have been demonstrated to be monoclonal proliferations of B- or T-lymphocytes, but in Hodgkin’s disease neither the cell of origin nor the monoclonal origin of the Reed-Sternberg cells has been established with certainty.


Gene Rearrangement Clonal Rearrangement Immunoglobulin Gene Rearrangement Interdigitating Reticulum Cell Sternberg Cell 
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Copyright information

© Kluwer Academic Publishers, Boston 1989

Authors and Affiliations

  • Sibrand Poppema
  • Marja G. L. Brinker
  • Lydia Visser

There are no affiliations available

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