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Evidence for a B-cell origin of the proliferating cells

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Hodgkin’s Disease in Children

Part of the book series: Cancer Treatment and Research ((CTAR,volume 41))

Abstract

Hodgkin’s disease differs from the non-Hodgkin’s lymphomas by the presence of reactive lymphocytes, histiocytes, plasma cells, fibroblasts and eosinophils in addition to the abnormal so-called Reed-Sternberg cells and their variants (Figure 1). Usually, Reed-Sternberg cells constitute only a minor population, whereas there is a majority of reactive small lymphocytes. During the disease, there is a general tendency to an increase in the number of Reed-Sternberg cells and a decrease in the lymphocyte admixture. The non-Hodgkin’s lymphomas have been demonstrated to be monoclonal proliferations of B- or T-lymphocytes, but in Hodgkin’s disease neither the cell of origin nor the monoclonal origin of the Reed-Sternberg cells has been established with certainty.

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Authors
  1. Sibrand Poppema
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  2. Marja G. L. Brinker
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  3. Lydia Visser
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Editors and Affiliations

  1. University of Groningen, The Netherlands

    W. A. Kamps  & G. B. Humphrey  & 

  2. Cross Cancer Institute, Canada

    S. Poppema

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© 1989 Kluwer Academic Publishers, Boston

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Poppema, S., Brinker, M.G.L., Visser, L. (1989). Evidence for a B-cell origin of the proliferating cells. In: Kamps, W.A., Humphrey, G.B., Poppema, S. (eds) Hodgkin’s Disease in Children. Cancer Treatment and Research, vol 41. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1739-5_2

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  • DOI: https://doi.org/10.1007/978-1-4613-1739-5_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8978-4

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