Pediatric Hodgkin’s Disease
Both radiation treatment and/or combination chemotherapy, classically with MOPP (nitrogen mustard, Oncovin (vincristine), prednisone, and procarbazine) are very effective in the eradication of Hodgkins disease. The relapse rate after treatment may be decreased by combining these modalities. Whether this is an appropriate strategy is a question of balance between cure of the disease and the early and late toxicity of treatment, with the comparison for limited disease being between initial bimodal treatment or sequential treatment in which radiation is used alone as the primary treatment and treatment is intensified at the time of first relapse, when necessary, using combination chemotherapy and usually additional radiation treatment. The importance of this question has been obvious ever since the curative role of combination chemotherapy with MOPP was established in the early 1970s. Because severe late toxicity may be delayed for many years, there is not yet a clear answer to the question, even in the much larger adult population with this disease.
KeywordsToxicity Hepatitis Lymphoma Leukemia Pneumonia
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