Pediatric Hodgkin’s Disease

Later Results and Toxicity—the Toronto Experience
  • Derek Jenkin
  • John Doyle
Part of the Cancer Treatment and Research book series (CTAR, volume 41)


Both radiation treatment and/or combination chemotherapy, classically with MOPP (nitrogen mustard, Oncovin (vincristine), prednisone, and procarbazine) are very effective in the eradication of Hodgkins disease. The relapse rate after treatment may be decreased by combining these modalities. Whether this is an appropriate strategy is a question of balance between cure of the disease and the early and late toxicity of treatment, with the comparison for limited disease being between initial bimodal treatment or sequential treatment in which radiation is used alone as the primary treatment and treatment is intensified at the time of first relapse, when necessary, using combination chemotherapy and usually additional radiation treatment. The importance of this question has been obvious ever since the curative role of combination chemotherapy with MOPP was established in the early 1970s. Because severe late toxicity may be delayed for many years, there is not yet a clear answer to the question, even in the much larger adult population with this disease.


Thyroid Carcinoma Herpes Zoster Carcinoma Follicular Thyroid Princess Margaret Hospital Staging Laparotomy 
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  1. 1.
    Jenkin D, Chan H, Freedman M, et al.: Hodgkin’s disease in children: treatment results with MOPP and low-dose, extended field irradiation. Cancer Treat Rep 66:949–959, 1982.PubMedGoogle Scholar

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© Kluwer Academic Publishers, Boston 1989

Authors and Affiliations

  • Derek Jenkin
  • John Doyle

There are no affiliations available

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