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Interferon Studies in Non-Human Primates

  • Chapter
Clinical Aspects of Interferons

Part of the book series: Developments in Medical Virology ((DIMV,volume 4))

Abstract

Biological response modifiers have multiple biological effects. Therefore, results obtained in vitro cannot be directly extrapolated to the therapeutic efficacy in humans. So animal studies are an essential prerequisite for the successful application of these agents in man. Interferons show a high degree of species specificity. Human interferon preparations are not active in “standard” laboratory animals as rats and mice. For studies in these species interferons from rat and mouse origin have to be produced. Initially the rodent interferons were produced from induced cell culture systems, which did not provide enough material for all the necessary studies. Recombinant DNA technology did not only solve the problem of production of human interferon, but also a number of animal interferons can now be produced in unlimited amounts (1).

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Author information

Authors and Affiliations

  1. Primate Center TNO, PO Box 5815, 2280 HV, Rijswijk, The Netherlands

    H. Schellekens & P. H. Van Der Meide

  2. Radiobiological Institute TNO, PO Box 5815, 2280 HV, Rijswijk, The Netherlands

    K. Nooter

Authors
  1. H. Schellekens
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  2. P. H. Van Der Meide
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  3. K. Nooter
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Editor information

Editors and Affiliations

  1. The Weizmann Institute of Science, Israel

    Michel Revel

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© 1988 Kluwer Academic Publishers, Boston

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Schellekens, H., Van Der Meide, P.H., Nooter, K. (1988). Interferon Studies in Non-Human Primates. In: Revel, M. (eds) Clinical Aspects of Interferons. Developments in Medical Virology, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1737-1_22

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  • DOI: https://doi.org/10.1007/978-1-4613-1737-1_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8977-7

  • Online ISBN: 978-1-4613-1737-1

  • eBook Packages: Springer Book Archive

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