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Toxic Effects

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Book cover Clinical Aspects of Interferons

Part of the book series: Developments in Medical Virology ((DIMV,volume 4))

Abstract

All interferons consistently cause a variety of symptoms and signs in man which are interpreted as “toxic” effects because they are unpleasant, but may reflect the normal pathophysiologic effects of high levels of endogenous interferon produced acutely during virus infections or chronically during active autoimmune processes. Many of the effects appear to be non-specific and are probably in part mediated by inflammatory prostaglandin synthesis. Toxic effects may be augmented by impurities in interferons derived from any source. They may be reduced by giving prostaglandin antagonists or steroids or by giving interferons in the evening. Both subjectively and objectively, acute febrile responses and associated symptoms are often reduced with repeated dosing, but tend to be replaced by chronic fatigue and malaise. Idiosyncratic responses such as glomerulonephritis, thrombocytopenia or thyroid disease may involve autoimmune processes.

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Author information

Authors and Affiliations

  1. Clinical Microbiology, University College Hospital, London, WC1E 6AU, UK

    G. M. S. Scott

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  1. G. M. S. Scott
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Editors and Affiliations

  1. The Weizmann Institute of Science, Israel

    Michel Revel

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© 1988 Kluwer Academic Publishers, Boston

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Scott, G.M.S. (1988). Toxic Effects. In: Revel, M. (eds) Clinical Aspects of Interferons. Developments in Medical Virology, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1737-1_19

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  • DOI: https://doi.org/10.1007/978-1-4613-1737-1_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8977-7

  • Online ISBN: 978-1-4613-1737-1

  • eBook Packages: Springer Book Archive

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