Interferon Treatment of Neuro-Endocrine Tumors of Pancreas and Gut

  • K. Öberg
  • B. Eriksson
  • I. Norheim
Part of the Developments in Medical Virology book series (DIMV, volume 4)


Neuro-endocrine gut tumors are relatively slowly growing neoplasms, but due to increased secretion of biologically active hormones, they often provoke severe clinical symptoms such as diarrhoea, flushing, asthma, hypoglycemia, recurrent ulcers, necrolytic migratory erythema and right heart failure (1,2,3,4). The majority of the secretory products from the neuro-endocrine tumors are peptide hormones, but also other substances are released, such as glycoproteins (HCG subunits and chromogranin A), serotonin, bradykinins and prostaglandins. The origin of neuro-endocrine gut and pancreatic tumors has been discussed and is not yet elucidated but they are all sharing in common so called APUD— characteristics, which means uptake of amines, precursors, storage and release of peptides and hormones (5). Neuro-endocrine pancreatic tumors are suggested to develop from pancreatic stem-cells (nesidioblasts) with the potential capacity to differentiate into both exocrine— and endocrine-type of cells.


Objective Response Carcinoid Tumor Interferon Treatment Growth Hormone Release Factor Severe Clinical Symptom 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Welbourn, R.B. Ann. Surg. 185: 1–12, 1977.PubMedCrossRefGoogle Scholar
  2. 2.
    Modlin, I.M. Surg. Gyn. Obstretics 149: 751–769, 1979.Google Scholar
  3. 3.
    öberg, K. Ups. J. Med. Sci. Suppl 39: 107–130, 1984.Google Scholar
  4. 4.
    Grahame-Smith, D.F. Am. J. Cardiol 21: 376–387, 1968.PubMedCrossRefGoogle Scholar
  5. 5.
    Pearse, A.G.E. Clin. Endocrinol. Metab. 17: 211–222, 1980.CrossRefGoogle Scholar
  6. 6.
    Williams, E.D and Sandler, M. Lancet i: 238–239, 1963.CrossRefGoogle Scholar
  7. 7.
    Lundquist, M. and Wilander, E. Cancer. In press.Google Scholar
  8. 8.
    Norheim, I., Theodorsson-Norheim, E., öberg, K and Brodin, E. J. Clin. Endocrinol. Metab. 63: 605–612, 1986.PubMedCrossRefGoogle Scholar
  9. 9.
    Cutitta, F, Carney, D.N., Mulshine, J., Moody, T.W., Fedorko, J., Fishier, A. and Minna, J.D. Nature 316: 823–826, 1985.CrossRefGoogle Scholar
  10. 10.
    Moertel, C.G and Hanley, J.A. Cancer Clin. Trials 2: 327–331, 1979.PubMedGoogle Scholar
  11. 11.
    Johansson, H., Boström, H., öberg, K. Ups. J. Med. Sci. Suppl 39: 179–189, 1984.Google Scholar
  12. 12.
    Wood, S.M., Kraenzlin, M.E., Adrian, T.E. and Bloom, S.R. Gut 26: 438–444, 1985.PubMedCrossRefGoogle Scholar
  13. 13.
    Cantell, K. and Hirvonen S. J. Gen-Virol. 39: 541–543, 1978.PubMedCrossRefGoogle Scholar
  14. 14.
    Eriksson, B., öberg, K., Alm, G., Lundqvist, G., Magnusson, A., Wide, L. and Wilander, E. Lancet ii: 1307–1309, 1986.CrossRefGoogle Scholar
  15. 15.
    öberg, K., Norheim, I., Lind, E., Jonsdottir, B., Magnusson, A., Lundqvist, G., Wide, L. and Alm, G. Cancer Treat. Rep. 70: 1297–1304, 1986.PubMedGoogle Scholar
  16. 16.
    Quesada, J.R. and Gultterman, J.U. Eur. J. Canc. Clin. Oncol. 24: 1213–1215, 1981.Google Scholar
  17. 17.
    Inglot, A. Arch. Virol. 76: 1–13, 1983.PubMedCrossRefGoogle Scholar
  18. 18.
    Funa, K., Gazdar, A.F., Doyle, A., Mattson, K., Niivanen, A., Koivuniemi, A., öberg, K., Wilander, E., Minna, J. and Linnoila, R.J. Clin. Immunol. and Immunopathol. 41: 159–164, 1986.CrossRefGoogle Scholar
  19. 19.
    Burman, P., Tötterman, H.T., öberg, K. and Karlsson, F.A. J. Clin. Endocrinol. Metabol. 63: 5: 1080–1090, 1986.CrossRefGoogle Scholar
  20. 20.
    Cantell, K. Immunobiol. 172: 231–242, 1986.Google Scholar
  21. 21.
    Kvols, L.K., Moertel, C.G., O’Connell, M.J., Schutt, A.J., Rubin, J. and Hahn, R.G. N. Engl. J. Med. 315: 663–666, 1986.PubMedCrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers, Boston 1988

Authors and Affiliations

  • K. Öberg
    • 1
  • B. Eriksson
    • 1
  • I. Norheim
    • 2
  1. 1.Ludwig Inst for Cancer Research, Uppsala BranchUniversity HospitalUppsalaSweden
  2. 2.Dept of Internal MedicineUniversity HospitalUppsalaSweden

Personalised recommendations