Interferon Treatment of Neuro-Endocrine Tumors of Pancreas and Gut
Neuro-endocrine gut tumors are relatively slowly growing neoplasms, but due to increased secretion of biologically active hormones, they often provoke severe clinical symptoms such as diarrhoea, flushing, asthma, hypoglycemia, recurrent ulcers, necrolytic migratory erythema and right heart failure (1,2,3,4). The majority of the secretory products from the neuro-endocrine tumors are peptide hormones, but also other substances are released, such as glycoproteins (HCG subunits and chromogranin A), serotonin, bradykinins and prostaglandins. The origin of neuro-endocrine gut and pancreatic tumors has been discussed and is not yet elucidated but they are all sharing in common so called APUD— characteristics, which means uptake of amines, precursors, storage and release of peptides and hormones (5). Neuro-endocrine pancreatic tumors are suggested to develop from pancreatic stem-cells (nesidioblasts) with the potential capacity to differentiate into both exocrine— and endocrine-type of cells.
KeywordsObjective Response Carcinoid Tumor Interferon Treatment Growth Hormone Release Factor Severe Clinical Symptom
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