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Osteosarcoma Management and Interferon

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Clinical Aspects of Interferons

Part of the book series: Developments in Medical Virology ((DIMV,volume 4))

Abstract

Human osteosarcoma is a malignant disease which requires multi-modality treatment including surgery and adjuvant therapy. In this article we have summarized various aspects pertinent to IFN therapy of human osteosarcoma. Different experimental approaches are described but we emphasize that IFN treatment should not be used as the primary single treatment in osteosarcoma. Osteosarcoma exerts biological effects which makes it possible to study biological parameters extensively. Such a biological approach might lead to an extensive combination treatment schedule and a diversified programme for the treatment of human osteosarcoma patients.

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References

  1. Dahlin, D.C. and Coventry, M.B. J. Bone Joint Surg. (Am). 49:101–110, 1967.

    CAS  Google Scholar 

  2. Broström, L-Å., Aparisi, T., Ingimarsson, S., Lagergren, C., Nilsonne, U., Strander, H. and Söderberg, C. Intern. J. Rad. Oncol. Biol. Phys. 6:1717–1721, 1980.

    Article  Google Scholar 

  3. Broström, L-Å., Aparisi, T., Ingimarsson, S., Lagergren, C., Nilsonne, U., Strander, H. and Söderberg, G. Intern. J. Rad. Oncol. Biol. Phys. 6:1711–1715, 1980.

    Article  Google Scholar 

  4. Broström, L-Å., Ingimarsson, S., Strander, H. and Söderberg, G. Acta Orothop. Scand. 51:589–594, 1980.

    Google Scholar 

  5. Ingimarsson, S., Cantell, K., Carlström, G., Dalton, B., Paucker, K. and Strander, H. Acta Med. Scand. 209:17–19, 1981.

    Article  PubMed  CAS  Google Scholar 

  6. Strander, H., Einhorn, S., Ingimarsson, S., Aparisi, T., Broström, L-Å., Nilsonne, U., Söderberg, C. and Midander, J. Third Ann. Intern. Cong. Interferon Res., Nov. 1–3, Miami, 1982.

    Google Scholar 

  7. Strander, H., Aparisi, T., Broström, L-Å., Einhorn, S., Ingimarsson, S., Nilsonne, U. and Söderberg, C. In: Current Concepts of Diagnosis and Treatment of Bone and Soft Tissue Tumors. Springer Verlag, 1984, pp. 119–130.

    Google Scholar 

  8. Strander, H., Aparisi, T., Broström, L-A., Einhorn, S., Ingimarsson, S., Nilsonne, U. and Söderberg, C. In: Interferon — Research, Clinical Application and Regulatory Considerations (Eds. K.Z. Zoon, P.D. Noguchi and T-Y. Lin), Elsevier, New York, 1984, pp. 247–253.

    Google Scholar 

  9. Strander, H. In: Interferon IV (Eds. N. Finter and R.K. Oldham), Elesevier Science Publ., Amsterdam 1985, pp. 135–143.

    Google Scholar 

  10. Strander, H. Adv. Cancer Res. 46:1–265, 1986.

    Article  PubMed  CAS  Google Scholar 

  11. Strander, H. Texas Rep. Biol. Med., in press, 1987.

    Google Scholar 

  12. Jaffe, N., Frei, E. III, Traggis, D. and Bishop, Y. N. Eng. J. Med. 291:994–997, 1974.

    Article  CAS  Google Scholar 

  13. Cortes, E.P., Holland, J.F., Wang, J.J., Sinks, L.F., Blom, J., Senn, H., Bank, A. and Glidewell, O. N. Eng. J. Med. 291:998–1000, 1974.

    Article  CAS  Google Scholar 

  14. Sutow, W.W., Sullivan, M.P. and Fernbach, D.J. Proc. Am. Assoc. Cancer Res. and ASCO 15:72, 1974.

    Google Scholar 

  15. Malawer, M.M., Abelson, H.T. and Suit, H.D. In: Cancer — Principles and Practice of Oncology (Eds. V.T. DeVita, S. Hellman and S.A. Rosenberg), 2 ed., Lippincott, Philadelphia, 1985, pp. 1293–1342.

    Google Scholar 

  16. Rosen, C. and Nirenberg, A. Cancer Treat. Rep. 66:1687–1697, 1982.

    PubMed  CAS  Google Scholar 

  17. Rosen, C. and Nirenberg, A. Progr. Clin. Biol. Res. 201:39–51, 1985.

    CAS  Google Scholar 

  18. Jaffe, N. Cancer Treat. Res. 24:223–233, 1985.

    Article  Google Scholar 

  19. Goorin, A.M., Delorey, M., Gelber, R.O., Price, K., Vawler, G., Jaffe, N., Watts, H., Link, M., Frei, E. III and Abelson, H.T. Cancer Treat. Symp. 3:155–159, 1985.

    Google Scholar 

  20. Rosen, C. Recent Results Cancer Res. 103:148–157, 1986.

    PubMed  CAS  Google Scholar 

  21. Strander, H. and Einhorn, S. Phil. Trans. R. Soc. Lond. B299:113–117, 1982.

    Google Scholar 

  22. Strander, H. and Einhorn, S. Am. J. Clin. Oncol. 5:297–301, 1982.

    Article  PubMed  CAS  Google Scholar 

  23. Strander, H. In: Interferon — From Molecular Biology to Clinical Application (Eds. D. Burke and A. Morris), Cambridge University Press, Cambridge, 1983, pp.7–33.

    Google Scholar 

  24. Borden, E. Interferon 5:43–83, 1983.

    PubMed  CAS  Google Scholar 

  25. Kirkwood, J.M. and Ernstoff, M.S. J. Clin. Oncol. 2:336–352, 1984.

    PubMed  CAS  Google Scholar 

  26. Strander, H. In: The Biology of the Interferon System 1984. (Eds. H. Kirchner and H. Schellekens), Elsevier Biomedical Div., Amsterdam, 1984, pp. 489–493.

    Google Scholar 

  27. Stringfellow, D.A. (Ed.) Clinical Application of Interferons and Their Inducers, 2nd ed, Marcel Dekker, Inc., 1986.

    Google Scholar 

  28. Cantell, K. Immunobiol. 172:231–242, 1986.

    CAS  Google Scholar 

  29. Delbruck, H.G., Allouche, M. and Jasmin, C. Biomedicine Expr. 33:239–241, 1980.

    CAS  Google Scholar 

  30. Degré, M. Acta Pathol. Microbiol. Scand. B. 88:219–223, 1980.

    PubMed  Google Scholar 

  31. Ito, M. and Buffett, R.F. J. Nat. Ca. Inst. 66:819–825, 1981.

    CAS  Google Scholar 

  32. Strander, H. and Einhorn, S. Int. J. Cancer 19:468–473, 1977.

    Article  PubMed  CAS  Google Scholar 

  33. Einhorn, S. and Strander, H. In: Human Interferon (Eds. W.R. Stinebring and P.J. Chappie), Plenum Publ. Corp., 1978, pp. 159–174.

    Google Scholar 

  34. Einhorn, S. and Strander, H. J. Gen. Virol. 35:573–577, 1977.

    Article  PubMed  CAS  Google Scholar 

  35. Rubin, B.J. and Gupta, S.L. Proc. Nat. Xcad. Sci. USA 77:5928–5932, 1980.

    Article  CAS  Google Scholar 

  36. Vastola, K.A., Diviak, L.F. and O’Malley, J.A. Proc. Am. Assoc. Cancer Res. 24:650, 1983.

    Google Scholar 

  37. Broström, L-Å. Cancer Lett. 10:83–90, 1980.

    Article  PubMed  Google Scholar 

  38. Dannecker, G., Treuner, J., Buck, J., Dilger, M. and Niethammer, D. J. Interf. Res. 5:541–550, 1985.

    Article  CAS  Google Scholar 

  39. Degrén, M. and Glasgow, L.A. Acta Pathol. Microbiol. Immunol. Scand. B91:389–394, 1983.

    Google Scholar 

  40. Glasgow, L.A., Crane, J.L., Kern, E.R. and Youngner, J.S. Cancer Treat. Rep. 62:1881–1888, 1978.

    PubMed  CAS  Google Scholar 

  41. Glasgow, L.A. and Kern, E.R. J. Nat. Cancer Inst. 67:207–212, 1981.

    PubMed  CAS  Google Scholar 

  42. Davies, M.E. and Field, A.K. J. Interf. Res. 3:89–95, 1983.

    Article  CAS  Google Scholar 

  43. Jasmin, C., Allouche, M., Judde, J.G. and Delbruck, H. Proc. Am. Assoc. Cancer Res. 22:261, 1981.

    Google Scholar 

  44. Satomi, H. Nippon Seikegeka Gakkai Zasshi, 57: 199–213, 1983.

    CAS  Google Scholar 

  45. Taylor, G.N., Kern. E.R., Braaten, B., Glasgow, L.A., Wrenn, M.E., Atherton, D.A., Mays, C.W., Charrier, K. and Ayoroa, G. J. Nat. Ca. Inst. 72:1137–1140, 1984.

    CAS  Google Scholar 

  46. Balkwill, F.R., Moodie, E.M., Freedman, C. and Fantes, K.H. Int. J. Cancer 30:231–235, 1982.

    Article  PubMed  CAS  Google Scholar 

  47. Gresser, I. and Tovey, M. Biochem. Biophys. Acta 516:231–247, 1978.

    PubMed  CAS  Google Scholar 

  48. Riviere, Y. and Hovanessian, A.G. Cancer Res. 43:4596–4599, 1983.

    PubMed  CAS  Google Scholar 

  49. Masuda, S., Fukuama, H. and Beppu, Y. Eur. J. Cancer Clin. Oncol. 19:1521–1528, 1983.

    Article  PubMed  CAS  Google Scholar 

  50. Bauer, H.C.F., Brosjö, O., Broström, L-Å., Nilsson, O.S., Reinholt, P.P. and Tribukait, B. Europ. J. Cancer Clin. Oncol. 2:821–830, 1986.

    Article  Google Scholar 

  51. Brosjö, O., Bauer, H.C.F., Broström, L-Å., Nilsonne, U., Nilsson, O.S., Reinholt, F.P., Strander, H. and Tribukait, B. Cancer Res. 45:5598–5602, 1985.

    PubMed  Google Scholar 

  52. Brosjö, O., Bauer, H.C.F., Broström, L-Å., Nilsson, O.S., Reinholt, F.P. and Tribukait, B. Cancer Res. 46:258–262, 1987.

    Google Scholar 

  53. Brosjö, O., Bauer, H.C.F., Nilsson, O.S. and Strander, H. In: The Biology of the Interferon System (Eds. K. Cantell and H. Schellekens), 1987, in press.

    Google Scholar 

  54. Embleton, M.J. Immunol. Ser. 23:181–207, 1984.

    CAS  Google Scholar 

  55. Embleton. M.J., Pimm, M.U. and Baldwin, R.W. In: Basic Mechanisms and Clinical Treatment of Tumor Metastasis (Eds. M. Torisu and T. Yoshida), Academic Press, New York, 1985, pp. 485–506.

    Google Scholar 

  56. Bruland, D., Fodstad, D., Funderud, S. and Pihl, A. Int. J. Cancer 38:27–31, 1986.

    Article  PubMed  CAS  Google Scholar 

  57. Shaw, A.R., Chan, J.K., Reid, S. and Seehafer, J. J. Nat. Ca. Inst. 74:1261–1268, 1985.

    CAS  Google Scholar 

  58. Vánky, F.T., Argov, S.A., Einhorn, S.A. and Klein, E. J. Exp. Med. 151:1151–1165, 1980.

    Article  Google Scholar 

  59. Einhorn, S., Blomgren, H., Jarstrand, C., Strander, H. and Wasserman, J. In: The Biology of the Interferon System 1983 (Eds. E. de Maeyer and H. Schellekens), Elsevier Science Publ., Amsterdam, 1983, pp. 347–352.

    Google Scholar 

  60. Einhorn, S., Ling. O., Einhorn, N. and Strander, H. J. Clin. Lab. Immunol., 1987, in press.

    Google Scholar 

  61. Einhorn, S., Ling. P., Einhorn, N., Strander, H. and Wasserman, J. Cancer Immunol. Immunother., 1987, in press.

    Google Scholar 

  62. Strander, H., Cantell, K., Carlström, G. and Jakobsson, P.A. J. Nat. Cancer Inst. 51:733–742, 1973.

    PubMed  CAS  Google Scholar 

  63. Nilsonne, U. Sem. Hop. Paris. 58:1764–1766, 1982.

    PubMed  CAS  Google Scholar 

  64. Strander, H. and Cantell. K. Ann. Med. Exp. Fenn. 44:265–273, 1966.

    PubMed  CAS  Google Scholar 

  65. Cantell, K., Hirvonen, S., Kauppinen, H-L. and Myllylä, G. Methods Enzymol. 78:29–38, 1981.

    Article  PubMed  CAS  Google Scholar 

  66. Cantell, K., Hirvonen, S. and Koistinen, C. Methods Enzymol. 78:499–505, 1981.

    Article  PubMed  CAS  Google Scholar 

  67. Ingimarsson, S., Cantell, K. and Strander, H. J. Inf. Dis. 240:560–563, 1979.

    Article  Google Scholar 

  68. Ingimarsson, S., Bergström, K., Broström, L-Å., Cantell, K. and Strander, H. Acta Med. Scand. 208:155–159, 1980.

    Article  PubMed  CAS  Google Scholar 

  69. Ingimarsson, S., Cantell, K. and Strander, H. In: Interferon — Properties and Clinical Uses (Eds. A. Khan, N.O. Hill and G.L. Dorn)., Leland Fikes Found. Press, Dallas, 1980, pp. 633–641.

    Google Scholar 

  70. Ingimarsson, S., Cantell, K., Carlström, G. and Strander, H. Intern. J. Cancer 26:395–399, 1980.

    Article  CAS  Google Scholar 

  71. Lange, B. and Levine, A.S. Cancer Treat. Rep. 66:1699–1704, 1982.

    PubMed  CAS  Google Scholar 

  72. Carter, S.K. Drugs 31:337–367, 1986.

    Article  PubMed  CAS  Google Scholar 

  73. Broström, L-Å., Strander, H. and Nilsonne, U. Clin. Orthop. 167:250–254, 1982.

    PubMed  Google Scholar 

  74. Dimitrov, N.V., Meyer, C., Strander, H., Einhorn, S. and Cantell, K. Ann. Clin. Lab. Sci. 14:32–29, 1984.

    PubMed  CAS  Google Scholar 

  75. Purfurst, C., Beron, G., Toragler, S., Kotz, R., Salzer-Kuntschik, M. and Winkler, K. Klin. Pädiatr. 197:233–238, 1985.

    Article  PubMed  CAS  Google Scholar 

  76. Winkler, K., Beron, G., Kotz, R., Salzer-Kuntschik, M., Beck, J., Beck, W., Brandeis, W., Ebell, W., Erttmann, R., Göbel, U., Havers, W., Henze, G., Hinderfeld, L., Höcker, P., Jobke, A., Jürgens, H., Kabisch, H., Landbeck, G., Preusser, P., Prindull, G., Ramach, W., Ritter, J., Sekera, J., Treuner, J. and Wüst, G. J. Clin. Oncol. 2:617–624, 1984.

    PubMed  CAS  Google Scholar 

  77. Kurzrock, R., Rosenblum, M.G., Quesada, J.R., Sherwin, S.A., Itri, L.M. and Gutterman, J.U. J. Clin. Oncol. 4:1677–1683, 1986.

    PubMed  CAS  Google Scholar 

  78. Ito, H., Murakami, K., Yanagawa, T., Ban, S., Sawamusa, H., Sakakida, K., Matsuo, A., Imanishi, J. and Kishida, T. Cancer 46:1562–1565, 1980.

    Article  PubMed  CAS  Google Scholar 

  79. Imanishi, J. and Kishida, T. Tex. Rep. Biol. Med. 41:647–652, 1982.

    CAS  Google Scholar 

  80. Caparros, B., Rosen, G. and Cunningham-Rundles, S. Proc. Am. Assoc. Cancer Res. 23:121, 1982.

    Google Scholar 

  81. Mossman, K.L., Hil, L.T. and Dritschilo, A. J. Nat. Med. Assoc. 74:1083–1087, 1982.

    CAS  Google Scholar 

  82. Taylor, W., Ivins, J., Dahlin, D., Edmonson, J. and Pritchard, D. Proc. Mayo Clin. 53:695–700, 1978.

    PubMed  CAS  Google Scholar 

  83. Nilsonne, U. Clin. Orthop. 191:21–26, 1984.

    PubMed  Google Scholar 

  84. Eckardt, J.J., Eilber, F.R., Grant, T.T., Mirra, J.M., Weisenberger, T.H. and Dorey, F.J. Cancer Treat. Symp. 3:117–130, 1985.

    Google Scholar 

  85. Matsunaga, E. J. Nat. Ca. Inst. 65:47–51, 1980.

    CAS  Google Scholar 

  86. Gilman, P.A., Wang. N., Fan, S.F., Reede, J., Khan, A. and Leventhal, B.G. Cancer Genet. Cytogenet. 17:123–132, 1985.

    Article  PubMed  CAS  Google Scholar 

  87. Hansen, M.F., Konfos, A., Gallie, B.L., Phillips, R.A., Fodstad, O., Brugger, A., Gedde-Dahl, T. and Cavenee, W.K. Proc. Nat. Acad. Sci. USA 82:6216–6220, 1985.

    Article  PubMed  CAS  Google Scholar 

  88. Dryja, T.P., Rapaport, J.M., Epstein, J., Goorin, A.M., Weichselbaum, R., Konfos, A. and Cavenee, W.K. Am. J. Hum. Genet. 38:59–66, 1986.

    PubMed  CAS  Google Scholar 

  89. Shapiro, F.D. and Eyre, D.R. J. Nat. Ca. Inst. 69:1009–1016, 1982.

    CAS  Google Scholar 

  90. Heldin, C.H., Westermark, B. and Wasteson, A. Exp. Cell. Res. 136:255–261, 1981.

    Article  PubMed  CAS  Google Scholar 

  91. Blatt, J., White, C., Dienes, S., Friedman, H. and Foley, T.P.Jr. Bioch. Bioph. Res. Comm. 123:373–376, 1984.

    Article  CAS  Google Scholar 

  92. Craves, D.T., Owen, A.J., Barth, R.K., Tempst, P., Winoto, A., Fors, L., Hood, L.E. and Antoniades, H.N., Science, 226:972–974, 1984.

    Article  Google Scholar 

  93. Ross, R., Raines, E.W. and Bowen-Pope, D.F. Cell 46:155–169, 1986.

    Article  PubMed  CAS  Google Scholar 

  94. Weich, H.A., Sebald, W., Schairer, H.U., and Hoppe, J., FEBS Lett. 198:344–348, 1986.

    Article  PubMed  CAS  Google Scholar 

  95. Heldin, C.H., Johnsson, A., Wennergren, S., Wernstedt, C., Betsholtz, C. and Westermark, B. Nature 329:511–514, 1986.

    Article  Google Scholar 

  96. Graves, D.T., Owen, A.J. and Antoniades, H.N. Cancer Res. 43:83–87, 1983.

    PubMed  CAS  Google Scholar 

  97. Betsholtz, C., Westermark, B. and Heldin, C.H. Cell 39:447–457, 1984.

    Article  PubMed  CAS  Google Scholar 

  98. Westermark, B. and Heldin, C-H. Med Oncol. ε Tumor Pharmacother. 3:177–183, 1986.

    CAS  Google Scholar 

  99. Samid, D., Flessate, D.M., Greene, J.J., Chang, E.H. and Friedman, R.M. Progr. Clin. Biol. Res. 202:203–209, 1985.

    CAS  Google Scholar 

  100. Strander, H. Ann. New York Acad. Sci. 350:168–170, 1980.

    Article  Google Scholar 

  101. Rossi, G.B. Interferon 6:31–68, 1985.

    PubMed  CAS  Google Scholar 

  102. Goldstein, D. and Laszlo, J. Cancer Res. 46:4315–4329, 1986.

    PubMed  CAS  Google Scholar 

  103. Ernberg, J., Einhorn, S., Strander, H. and Klein, G. Biomedicine 35:190–193, 1981.

    PubMed  CAS  Google Scholar 

  104. Taylor, W.F., Ivins, J.C., Pritchard, D.J., Dahlin, D.C., Gilchrist, G.S. and Edmonson, J.H. Mayo Clin. Proc. 60:91–104, 1985.

    PubMed  CAS  Google Scholar 

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Strander, H. et al. (1988). Osteosarcoma Management and Interferon. In: Revel, M. (eds) Clinical Aspects of Interferons. Developments in Medical Virology, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1737-1_14

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